全文获取类型
收费全文 | 4075篇 |
免费 | 250篇 |
国内免费 | 42篇 |
专业分类
耳鼻咽喉 | 29篇 |
儿科学 | 63篇 |
妇产科学 | 39篇 |
基础医学 | 486篇 |
口腔科学 | 192篇 |
临床医学 | 318篇 |
内科学 | 946篇 |
皮肤病学 | 82篇 |
神经病学 | 384篇 |
特种医学 | 188篇 |
外科学 | 460篇 |
综合类 | 23篇 |
预防医学 | 130篇 |
眼科学 | 120篇 |
药学 | 349篇 |
中国医学 | 32篇 |
肿瘤学 | 526篇 |
出版年
2023年 | 23篇 |
2022年 | 47篇 |
2021年 | 106篇 |
2020年 | 63篇 |
2019年 | 72篇 |
2018年 | 82篇 |
2017年 | 63篇 |
2016年 | 90篇 |
2015年 | 93篇 |
2014年 | 109篇 |
2013年 | 128篇 |
2012年 | 212篇 |
2011年 | 239篇 |
2010年 | 140篇 |
2009年 | 124篇 |
2008年 | 204篇 |
2007年 | 252篇 |
2006年 | 205篇 |
2005年 | 194篇 |
2004年 | 197篇 |
2003年 | 179篇 |
2002年 | 171篇 |
2001年 | 116篇 |
2000年 | 140篇 |
1999年 | 97篇 |
1998年 | 56篇 |
1997年 | 45篇 |
1996年 | 39篇 |
1995年 | 18篇 |
1994年 | 19篇 |
1993年 | 35篇 |
1992年 | 61篇 |
1991年 | 55篇 |
1990年 | 78篇 |
1989年 | 75篇 |
1988年 | 51篇 |
1987年 | 62篇 |
1986年 | 40篇 |
1985年 | 39篇 |
1984年 | 42篇 |
1983年 | 26篇 |
1979年 | 26篇 |
1978年 | 15篇 |
1977年 | 18篇 |
1976年 | 19篇 |
1974年 | 19篇 |
1972年 | 26篇 |
1969年 | 17篇 |
1968年 | 17篇 |
1967年 | 17篇 |
排序方式: 共有4367条查询结果,搜索用时 515 毫秒
101.
Ryohei Nishino Haruko Daga Rumie Sasaki Chie Moritani Nobuyuki Ohashi Ken-ichi Arita Megumu Fujiwara 《Nihon Kokyūki Gakkai zasshi》2003,41(7):491-495
A 70-year-old man who had worked in a stonepit for about fifty years was admitted to our hospital for detailed examination of the signs of pneumoconiosis (3/3, q) and a nodular shadow in the right upper lung field. Under a clinical diagnosis of lung cancer complicated with pneumoconiosis, right upper lobectomy with a right S6 resection was performed. Pathological examination revealed moderately differentiated adenocarcinoma of the right S2, well-differentiated adenocarcinoma of the right S6, and a squamous cell carcinoma of the right S1 which was not detected by chest CT. In addition to the difficulty of diagnosing lung cancer in a patient with severe pneumoconiosis, treatment for lung cancer may be limited by the poor pulmonary function that results from pneumoconiosis. Although the labor administration's decision that lung cancer patients with concomitant pneumoconiosis deserve compensation can be evaluated as a good one, the study of the relationship between pneumoconiosis and lung cancer needs further study through follow-up examination of pneumoconiosis cases. 相似文献
102.
Kazuki Kurihara Hiroshi Kawaguchi Takayuki Obata Hiroshi Ito Eiji Okada 《Biomedical optics express》2015,6(9):3197-3209
Subject-specific head models of which their geometry is based on structural magnetic resonance images are essential to accurately estimate the spatial sensitivity profiles for image reconstruction in diffuse optical tomography. T1-weighted magnetic resonance images, which are commonly used for structural imaging, are not sufficient for the threshold-based segmentation of the superficial tissues. Two types of pulse sequences, which provide a high contrast among the superficial tissues, are introduced to complement the segmentation to construct the subject-specific head models. The magnetic resonance images acquired by the proposed pulse sequences are robust to the threshold level and adequate for the threshold-based segmentation of the superficial tissues compared to the T1- and T2-weighted images. The total scan time of the proposed pulse sequences is less than one-fourth of that for the T2-weighted pulse sequence.OCIS codes: (170.2655) Functional monitoring and imaging, (170.3660) Light propagation in tissues 相似文献
103.
Mai Inoue Masaya Sasaki Azusa Takaoka Mika Kurihara Hiromi Iwakawa Shigeki Bamba Hiromitsu Ban Akira Andoh 《Journal of Clinical Biochemistry and Nutrition》2015,56(3):215-219
We investigated the changes in energy expenditure during induction therapy in patients with severe or moderate ulcerative colitis. Thirteen patients (10 men, 3 women; mean age, 36.5 years) with ulcerative colitis admitted to the Shiga University Hospital were enrolled in this study. We measured the resting energy expenditure and respiratory quotients of these patients before and after induction therapy with indirect calorimetry. We analyzed the changes of nutritional status and serum inflammatory cytokine levels and also evaluated the relationship between energy metabolism and disease activity by using the Seo index and Lichtiger index. The resting energy expenditure was 26.3 ± 3.8 kcal/kg/day in the active stage and significantly decreased to 23.5 ± 2.4 kcal/kg/day after induction therapy (p<0.01). The resting energy expenditure changed in parallel with the disease activity index and C-reactive protein and inflammatory cytokine levels. The respiratory quotient significantly increased after induction therapy. Thus, moderate to severe ulcerative colitis patients had a hyper-metabolic status, and the energy metabolism of these patients significantly changed after induction therapy. Therefore, we recommend that nutritional management with 30–34 kcal/kg/day (calculated as measured resting energy expenditure × activity factor, 1.3) may be optimal for hospitalized ulcerative colitis patients. 相似文献
104.
105.
Measuring quality of life in patients with head and neck cancer: Update of the EORTC QLQ‐H&N Module,Phase III
下载免费PDF全文
![点击此处可从《Head & neck》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Susanne Singer Cludia Araújo Juan Ignacio Arraras Ingo Baumann Andreas Boehm Bente Brokstad Herlofson Joaquim Castro Silva Wei‐Chu Chie Sheila Fisher Orlando GuntinasLichius Eva Hammerlid María Elisa Irarrzaval Marianne Jensen Hjermstad Kenneth Jensen Naomi Kiyota Lisa Licitra Ourania NicolatouGalitis Monica Pinto Marcos Santos Claudia Schmalz Allen C. Sherman Iwona M. Tomaszewska Irma Verdonck de Leeuw Noam Yarom Paola Zotti Dirk Hofmeister 《Head & neck》2015,37(9):1358-1367
106.
James M. Walter Chitaru Kurihara Thomas C. Corbridge Ankit Bharat 《Heart & lung : the journal of critical care》2018,47(4):398-400
Background
Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is increasingly utilized in the management of severe acute respiratory distress syndrome (ARDS). Providers who care for patients on VV-ECMO should be familiar with common circuit complications.Objectives
To provide an example of a common complication, circuit “chugging,” and suggest a management algorithm which aims to avoid excessive fluid administration to patients with ARDS.Methods
We use a clinical case to illustrate chugging and discuss potential management strategies.Results
Our patient received frequent boluses of albumin for intermittent circuit chugging contributing to a net positive fluid balance of roughly 6 liters 4 days after cannulation.Conclusions
Chugging is a common complication for patients on VV ECMO. A thoughtful approach to management may help limit potentially harmful fluid administration for patients with ARDS. 相似文献107.
We investigated the glucose transporter mRNAs expressed in FRTL5, a rat thyroid cell line, and their regulation by TSH by means of the polymerase chain reaction. FRTL5 cells as well as rat thyroid tissue expressed three types of glucose transporter mRNAs: GLUT1 or erythrocyte/HepG2/brain isoform, GLUT2 or pancreatic beta-cell/liver isoform, and GLUT4 or muscle/fat isoform. GLUT1 mRNA predominated, GLUT4 mRNA was minor, and GLUT2 mRNA expression was faint. Incubation of FRTL5 cells with TSH induced a time- and concentration-dependent increase in GLUT1 mRNA levels, while GLUT4 mRNA levels were decreased. The response of GLUT1 mRNA to TSH was evident at 3 h, and the maximal response was achieved at 12 h. TSH at a dose of 1 mU/ml elicited an approximately 3-fold increase in GLUT1 mRNA levels. (Bu)2cAMP (1 mM), 8-bromo-cAMP (1 mM), and forskolin (50 microM) mimicked the effect of TSH on GLUT1 and GLUT4 mRNA levels. The increase in GLUT1 mRNA by TSH was correlated with the increase in GLUT1 protein and the increase in 2-deoxyglucose transport activity. These observations suggest that in thyroid cells, TSH stimulates glucose transport at least in part by enhancing GLUT1 gene expression, and that the effect of TSH on GLUT1 and GLUT4 mRNA levels is mediated by a cAMP-dependent pathway. 相似文献
108.
Identification of simultaneous mutation of fibrinogen alpha chain and protein C genes in a Japanese kindred 总被引:2,自引:0,他引:2
Watanabe K Shibuya A Ishii E Kurihara M Inoue S Ono M Wada Y Wakiyama M Zaitsu M Iida H Muraoka K Kinoshita S Hamasaki N 《British journal of haematology》2003,120(1):101-108
Afibrinogenaemia usually induces a bleeding tendency during infancy, whereas protein C deficiency increases susceptibility to thrombosis in children or adolescence. Mutations of these genes have been, therefore, established as independent risk factors for coagulation disorders. We describe the homozygous mutation of the fibrinogen alpha chain gene and additional heterozygous mutation of the protein C gene in a male infant who showed prolonged umbilical bleeding after birth. On examination, the plasma fibrinogen was undetectable, and the activity and antigen level of protein C were reduced. The patient showed no fibrinogen Aalpha chain as well as Bbeta and gamma chains by Western blotting. The sequencing analysis showed the homozygous deletion of 1238 bases from intron 3 at position 2008 to intron 4 at position 3245 in the fibrinogen alpha chain gene. Both parents were heterozygous carriers of this mutation. In this patient, an additional mutation was also detected in the protein C gene: the heterozygous deletion of exon 7 at position 6161-6163 or 6164-6166, resulting the deletion of one amino acid (Lys150 or 151). His mother was also a carrier of this mutation. As the simultaneous mutation of the fibrinogen alpha chain and protein C genes has not been previously reported, the influence of the interaction between these two mutations on the clinical manifestations of this patient should be carefully monitored for a long period. 相似文献
109.
Endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in vascular smooth muscle. 总被引:16,自引:0,他引:16
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
K Goto Y Kasuya N Matsuki Y Takuwa H Kurihara T Ishikawa S Kimura M Yanagisawa T Masaki 《Proceedings of the National Academy of Sciences of the United States of America》1989,86(10):3915-3918
Endothelin is a potent endothelium-derived vasoconstrictor peptide recently characterized from porcine and human vascular endothelial cells. Here we provide evidence that endothelin activates the dihydropyridine-sensitive, voltage-dependent Ca2+ channel in porcine coronary artery smooth muscle. The vasoconstrictor action of endothelin is efficiently antagonized by low doses of the dihydropyridine Ca2+-channel blocker nicardipine. Endothelin augments the Ca2+-induced contraction in a high-K+ depolarizing solution, markedly enhances high-threshold Ca2+-channel current on the whole-cell patch clamp recording, and causes a sustained increase in the intracellular Ca2+ that is largely dependent on extracellular Ca2+. These findings suggest that endothelin exerts its vasoconstrictor effect by either directly or indirectly activating the voltage-dependent Ca2+ channel. 相似文献