全文获取类型
收费全文 | 306篇 |
免费 | 24篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 6篇 |
基础医学 | 48篇 |
临床医学 | 20篇 |
内科学 | 48篇 |
皮肤病学 | 1篇 |
神经病学 | 52篇 |
特种医学 | 7篇 |
外科学 | 18篇 |
预防医学 | 61篇 |
眼科学 | 5篇 |
药学 | 33篇 |
中国医学 | 1篇 |
肿瘤学 | 35篇 |
出版年
2023年 | 4篇 |
2022年 | 10篇 |
2021年 | 11篇 |
2020年 | 8篇 |
2019年 | 10篇 |
2018年 | 12篇 |
2017年 | 14篇 |
2016年 | 14篇 |
2015年 | 10篇 |
2014年 | 12篇 |
2013年 | 27篇 |
2012年 | 24篇 |
2011年 | 26篇 |
2010年 | 11篇 |
2009年 | 11篇 |
2008年 | 25篇 |
2007年 | 17篇 |
2006年 | 16篇 |
2005年 | 6篇 |
2004年 | 10篇 |
2003年 | 2篇 |
2002年 | 5篇 |
2001年 | 2篇 |
2000年 | 3篇 |
1999年 | 2篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1991年 | 3篇 |
1990年 | 5篇 |
1989年 | 8篇 |
1988年 | 1篇 |
1987年 | 6篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1984年 | 3篇 |
1983年 | 1篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1974年 | 1篇 |
1973年 | 1篇 |
1968年 | 1篇 |
排序方式: 共有336条查询结果,搜索用时 922 毫秒
11.
Nicolò Pecorelli Marco Braga Claudio Doglioni Gianpaolo Balzano Michele Reni Stefano Cereda Luca Albarello Renato Castoldi Giovanni Capretti Valerio Di Carlo 《Journal of gastrointestinal surgery》2013,17(3):488-493
Background
Preoperative chemotherapy (PCHT) has recently been proposed also in patients with resectable pancreatic adenocarcinoma. Few data are currently available on the impact of PCHT on short-term postoperative outcome after pancreatic resection. The objective of this study is to assess the impact of PCHT on pancreatic structure and short-term outcome after surgical resection.Methods
Fifty consecutive patients successfully underwent resection after PCHT. Each patient was matched with two control patients with pancreatic adenocarcinoma selected from our prospective electronic database. Match criteria were age (±3 years), gender, American Society of Anesthesiologist score, type of resection, pancreatic duct diameter (±1 mm), and tumor size (±5 mm). Primary endpoint was morbidity rate. Secondary endpoints were pancreatic parenchymal structure, mortality rate, and length of hospital stay (LOS).Results
Both degree of fibrosis and fatty infiltration of the pancreas were similar in the two groups. Overall morbidity rate was 48.0 % in the PCHT group vs. 54.0 % in the control group (p?=?0.37). Pancreatic fistula rate was 18.0 % in the PCHT group vs. 25.0 % in the control group (p?=?0.41). Mortality was 4.0 % in the PCHT group vs. 2.0 % in the control group (p?=?0.60). Mean LOS (days) was 12.7 in the PCHT group vs. 12.4 in the control group (p?=?0.74). There was no difference in resection margin status, while the rate of patients without nodal involvement was higher in the PCHT group (46.0 vs. 23.0 %, p?=?0.004).Conclusion
PCHT did not induce significant structural changes in pancreatic parenchyma and did not adversely affect short-term outcome after surgery. 相似文献12.
Carlo W. Cereda Giovanni Bianco Michael Mlynash Nicole Yuen Abid Y. Qureshi Archana Hinduja Seena Dehkharghani Adam E. Goldman-Yassen Kevin Li-Chun Hsieh Dan-Victor Giurgiutiu Dan Gibson Emmanuel Carrera Fana Alemseged Tobias D. Faizy Jens Fiehler Marco Pileggi Bruce Campbell Gregory W. Albers Jeremy J. Heit 《Annals of neurology》2022,91(1):23-32
13.
Ajmone Paola Francesca Allegri Beatrice Cereda Anna Michelini Giovanni Dall’Ara Francesca Mariani Milena Rigamonti Claudia Selicorni Angelo Vizziello Paola Costantino Maria Antonella 《Journal of autism and developmental disorders》2022,52(11):4763-4773
Journal of Autism and Developmental Disorders - Behavioural phenotype and autism-related traits of 38 patients affected by Cornelia de Lange syndrome (CdLS) were assessed using a specific... 相似文献
14.
Expanding the clinical spectrum of the ‘HDAC8‐phenotype’ – implications for molecular diagnostics,counseling and risk prediction 下载免费PDF全文
I. Parenti C. Gervasini J. Pozojevic K.S. Wendt E. Watrin J. Azzollini D. Braunholz K. Buiting A. Cereda H. Engels L. Garavelli R. Glazar B. Graffmann L. Larizza H.J. Lüdecke M. Mariani M. Masciadri J. Pié F.J. Ramos S. Russo A. Selicorni M. Stefanova T.M. Strom R. Werner J. Wierzba G. Zampino G. Gillessen‐Kaesbach D. Wieczorek F.J. Kaiser 《Clinical genetics》2016,89(5):564-573
Cornelia de Lange syndrome (CdLS) is a clinically heterogeneous disorder characterized by typical facial dysmorphism, cognitive impairment and multiple congenital anomalies. Approximately 75% of patients carry a variant in one of the five cohesin‐related genes NIPBL, SMC1A, SMC3, RAD21 and HDAC8. Herein we report on the clinical and molecular characterization of 11 patients carrying 10 distinct variants in HDAC8. Given the high number of variants identified so far, we advise sequencing of HDAC8 as an indispensable part of the routine molecular diagnostic for patients with CdLS or CdLS‐overlapping features. The phenotype of our patients is very broad, whereas males tend to be more severely affected than females, who instead often present with less canonical CdLS features. The extensive clinical variability observed in the heterozygous females might be at least partially associated with a completely skewed X‐inactivation, observed in seven out of eight female patients. Our cohort also includes two affected siblings whose unaffected mother was found to be mosaic for the causative mutation inherited to both affected children. This further supports the urgent need for an integration of highly sensitive sequencing technology to allow an appropriate molecular diagnostic, genetic counseling and risk prediction. 相似文献
15.
Arif A. Khokhar BMBCh Alessandra Laricchia MD Francesco Ponticelli MD Won-Keun Kim MD Francesco Gallo Damiano Regazzoli MD Marco Toselli MD Alessandro Sticchi MD Rossella Ruggiero MD Alberto Cereda MD Adriana Zlahoda-Huzior MD Andrea Fisicaro MD Ilja Gardi MD Antonio Mangieri MD Bernhard Reimers MD Dariusz Dudek MD Antonio Colombo MD Francesco Giannini MD 《Catheterization and cardiovascular interventions》2021,98(3):595-604
16.
Lucas M. Arantes Eduardo V. V. Varejão Karin J. Pelizzaro‐Rocha Cíntia M. S. Cereda Eneida de Paula Maicon P. Lourenço Hélio A. Duarte Sergio A. Fernandes 《Chemical biology & drug design》2014,83(5):550-559
The aim of this work was to study the interaction between the local anesthetic benzocaine and p‐sulfonic acid calix[n]arenes using NMR and theoretical calculations and to assess the effects of complexation on cytotoxicity of benzocaine. The architectures of the complexes were proposed according to 1H NMR data (Job plot, binding constants, and ROESY) indicating details on the insertion of benzocaine in the cavity of the calix[n]arenes. The proposed inclusion compounds were optimized using the PM3 semiempirical method, and the electronic plus nuclear repulsion energy contributions were performed at the DFT level using the PBE exchange/correlation functional and the 6‐311G(d) basis set. The remarkable agreement between experimental and theoretical approaches adds support to their use in the structural characterization of the inclusion complexes. In vitro cytotoxic tests showed that complexation intensifies the intrinsic toxicity of benzocaine, possibly by increasing the water solubility of the anesthetic and favoring its partitioning inside of biomembranes. 相似文献
17.
18.
19.
Strokes restricted to the insular cortex 总被引:9,自引:0,他引:9
OBJECTIVE: To characterize clinically acute insular strokes from four patients with a first ever acute stroke restricted to the insula on MRI. METHODS: The authors studied the clinical presentation of four patients with a first ever acute stroke restricted to the insula on MRI. RESULTS: The authors found five main groups of clinical presentations: 1) somatosensory deficits in three patients with posterior insular stroke (two with a transient pseudothalamic sensory syndrome, one with partial distribution); 2) gustatory disorder in a patient with left posterior insular infarct; 3) vestibular-like syndrome, with dizziness, gait instability, and tendency to fall, but no nystagmus, in three patients with posterior insular strokes; 4) cardiovascular disturbances, consisting of hypertensive episodes in a patient with a right posterior insular infarct; and 5) neuropsychological disorders, including aphasia (left posterior insula), dysarthria, and transient somatoparaphrenia (right posterior insula). CONCLUSION: Strokes restricted to the posterior insula may present with pseudothalamic sensory and vestibular-like syndromes as prominent clinical manifestations, but also dysarthria and aphasia (in left lesions), somatoparaphrenia (right lesions) and gustatory dysfunction and blood pressure with hypertensive episodes in right lesions; we did not find acute dysphagia reported in anterior, insular strokes. 相似文献
20.
A Giachetti F Pagani R Micheletti A Brambilla E Cereda A Donetti 《Agents and actions》1985,16(3-4):173-175
Mifentidine, a representative compound of a novel class of H2-antagonists, has been investigated for its ability to interact with H2-receptors and to inhibit gastric acid secretion. Affinity estimates (KB) of mifentidine obtained from in vitro studies on cardiac and gastric mucosal histamine (H2) receptors were in the 20-50 nM range. Mifentidine appeared to be endowed with strong anti-secretory properties against histamine-stimulated secretion in the anaesthetized rat and in the conscious dog. Distinct features of mifentidine were considerable bioavailability and duration of anti-secretory effect. 相似文献