西安市50岁以上居民食物频率问卷准确性及重现性研究

目的对用于评价西安城区居民膳食营养状况的西安食物频率问卷(FFQ)的重现性和准确性进行食物组的研究。方法在西安城区随机抽取出125名50～80岁当地居民,共完成6轮的食物摄入情况的调查,其中4轮24小时膳食回顾调查(24HDRs)的结果作为参考,通过第一轮FFQ结果与第二轮FFQ以及4轮24HDRs结果之间的比较分别进行FFQ的重现性和准确性研究。结果各个食物组在两轮FFQ间的Spearman相关系数在0.38(糕点类)～0.74(茶类)。第二轮FFQ与4轮24HDRs均值间的相关系数在0.12～0.74之间,经过个体内方差校正后,相关系数均有所提高。结论西安食物频率问卷可以相对准确、可靠地评价西安城区50岁以上居民的膳食营养状况。     

直视下尿道内切开术的再认识

目的：观察直视下尿道内切开术（DVIU）的长期疗效,重新评价DVIU的临床应用价值。方法：回顾性分析2003年1月～2007年1月收治的65例尿道狭窄或闭锁患者行DVIU及术后随访的临床资料：狭窄长度0．5～2．0cm,平均1．2cm。其中≤1．0cm者25例,1．1～2．0cm者40例。30例行尿道超声检查测量尿道瘢痕厚度,其中瘢痕厚度≤1cm者10例,〉1cm者20例,瘢痕长度和厚度均≤1cm者9例。结果：65例共行DVIU72例次,72例次内切开手术均获得成功。63例获得随访,随访时间24～60个月,平均40．5个月。48例（76．2％）因狭窄复发而最终接受开放手术。尿道超声显示瘢痕厚度≤1cm的10例中,只有1例接受手术;瘢痕厚度〉1cm的20例中,18例接受手术;瘢痕长度和厚度均≤1cm的9例均未行手术。结论：DVIU适合于狭窄段和瘢痕厚度均〈1cm的患者,切开次数以1次为宜,手术疗效与严格掌握适应证密切相关。     

尿道狭窄患者围手术期尿液TGF-β1变化的分析研究

目的:探讨尿道狭窄患者围手术期尿液TGF-β1浓度变化情况以及影响该浓度的相关因素.方法:使用ELISA试剂盒对29例尿道狭窄患者术前1个月及术后1个月尿液中TGF-β1进行测定及记录.同期取泌尿系统其他手术的14例患者作为对照组,测定其术后1个月尿液中TGF-β1浓度.结果:检测结果显示实验组在接受手术治疗后尿液中TGF-β1含最较对照组有显著增高(P＜0.05).同时实验组患者术前和术后尿液TGF-β1浓度也存在明显差异(P＜0.05).在相关性因素的分析中,前尿道狭窄患者术后尿液中TGF-β1含量的变化幅度较后尿道狭窄患者更为显著(P＜0.05),同时采用自体组织替代技术较传统端端吻合技术以及内镜切开技术更能引起尿液中TGF-β1的明显变化(P＜0.05).但年龄、既往手术次数均未能引起患者术后TGF-β1的变化.结论:狭窄部位、手术方式都与患者尿液中 TGF-β1的含量存在一定的联系,而年龄及既往手术史等因素未发现与患者体内TGF-β1含量有较大的联系.     

超长段尿道狭窄术后勃起功能的评估

目的 探讨自体组织替代治疗超长段尿道狭窄对勃起功能的影响.方法 回顾性分析2007年1月至2009年1月采用不同自体组织补片(阴囊纵隔、包皮内板、口腔黏膜)Onlay术式替代治疗超长段男性尿道狭窄患者的临床资料,并随访患者ⅡEF-5评分、QOL评分及最大尿流率,并与术前相应情况进行分析.结果 根据研究标准收集23份有效数据.患者术前及术后3、6、12个月QOL评分分别为5.22±0.75、1.22±1.40、1.82±1.17、2.07±0.46,最大尿流率分别为(3.93±3.62)、(22.46±4.65)、(23.81±6.22)、(21.52±7.44)ml/s,术后不同时期均较术前明显改善(P＜0.01).术前及术后3、6、12个月ⅡEF-5评分分别为14.47±9.55、14.70±5.32、14.26±3.29和14.58±3.62,组间比较差异无统计学意义(P＞0.05).9例狭窄部位累及至后尿道者术后3、6、12个月ⅡEF-5评分分别为11.67±2.59、12.35±1.83、13.19±1.67,14例单纯前尿道狭窄者分别为17.79±6.42、16.57±4.78、16.01±3.85,2组间比较差异均有统计学意义(P＜0.05).狭窄累及后尿道患者多元线性回归分析中,年龄、受伤时间及尿道狭窄段长度与替代术后ⅡEF-5评分呈多元线性相关.结论 自体组织替代治疗男性超长段尿道狭窄对勃起功能影响不明显;狭窄段累及后尿道时可能对患者勃起功能产生一定影响.患者年龄和受伤时间对勃起功能有协同影响作用.

Abstract：

Objective To investigate the effect of substitutive reconstruction of long urethral stricture on male erectile function. Methods From January 2007 to January 2009, 23 patients with anterior or posterior long urethral stricture were accepted for a variety of onlay substitutive procedures, including lingual mucosa, perputial skin, and mid-scrotal skin. During the follow-up, data from the International Index of Erectile Function-5 (ⅡEF-5) questionnaire and the Quality of Life (QOL) questionnaire as well as maximal flow rate were recorded. All data were compared with those obtained before surgery. Results Significant improvement in QOL (1.22 ± 1.40, 1.82 ± 1. 17,2.07± 0.46) and maximal flow rate (22.46± 4.65, 23.81 ± 6.22, 21.52 ±7.44 ) could be observed 3, 6 and 12 months after surgery compared with those before surgery (5. 22 ± 0. 75, 3. 93 ± 3. 62)(P＜0.01). No significant differences in the responses to the ⅡEF-5 questionnaire were observed among all patients during the follow-up (P＞0. 05). At the 3, 6 and 12 months after procedure,scores of ⅡEF-5 in patients with anterior urethral stricture ( 17.79 ± 6.42, 16. 57 ± 4. 78, 16.01 ±3.85) were significantly higher than those with posterior urethral stricture (11.67 ± 2.59, 12.35 ±1.83,13. 19±1.67, P＜0.05). In patients with posterior urethral stricture, the multiple linear regression showed that age, time interval of injury and length of stricture were related to the ⅡEF-5score (P＜0.05). Conclusions Substitutive reconstruction for treating the long urethral stricture has little effect on male erectile function. But the location of stricture, especially extended to posterior urethra, may have impact on the erectile function.     

The management of stage I--II Hodgkin's disease with irradiation alone or combined modality therapy: the Stanford experience

At Stanford University, between 1968 and 1978, 230 patients with pathologic stage I--II Hodgkin's disease were treated on prospective clinical trials with either irradiation alone or irradiation followed by 6 cycles of adjuvant combination chemotherapy. The actuarial survival at 10 yr was 84% for patients in either treatment group. Freedom from relapse at 10 yr was 77% among patients treated with irradiation alone and 84% after treatment with combined modality therapy [p(Gehan) = 0.09]. Freedom from second relapse at 10 yr was 89% and 94%, respectively [p(Gehan) = 0.56]. Several prognostic factors were evaluated in order to identify patients at high risk for relapse or with poor ultimate survival after initial treatment with irradiation alone. Systemic symptoms, histologic subtype, age, and limited extranodal involvement (E-lesions) did not affect the prognosis of patients and failed to identify patients whose survival could be improved by the routine use of combined modality therapy. Patients with large mediastinal masses (mediastinal mass ratio greater than or equal to 1/3) had a significantly poorer freedom from relapse when treated with irradiation alone than when treated initially with combined modality therapy [45% versus 81% at 10 yr, p(Gehan) = 0.03). The 10-yr survival of these patients, however, was not significantly different (84% versus 74%). The implications of these observations on the management of patient with early stage Hodgkin's disease are discussed.     

冠心病中医体质类型、客观化及临床应用研究进展

冠心病的发生、发展与中医体质存在密切关系.冠心病患者在遗传物质的差异、生长地域环境的不同等影响因素下表现出中医体质类型的差异性.诸多体质学研究发现冠心病患者以偏颇体质、兼夹体质为主.中医体质研究从宏观角度反映冠心病患者的疾病特质,中医体质分布规律的研究对冠心病的认识具有重要意义,本文就近10年来冠心病中医体质类型分布、...     

Percutaneous drainage access: a simplified coaxial technique

We describe an access technique that we have used in 150 nephrostomy and biliary drainage procedures and for access to some abscesses and viscera. The system provides safe coaxial access with a 22-gauge removable hub needle, which then acts as a guide wire and is replaced by an 18-gauge cannula. A major advantage is that only one guide wire is used (0.038-inch) for the entire drainage procedure. No significant complications have occurred to date with this method.