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71.
Amygdalar atrophy in panic disorder patients detected by volumetric magnetic resonance imaging 总被引:6,自引:0,他引:6
Massana G Serra-Grabulosa JM Salgado-Pineda P Gastó C Junqué C Massana J Mercader JM Gómez B Tobeña A Salamero M 《NeuroImage》2003,19(1):80-90
It has been suggested that the pathophysiology of panic disorder (PD) may involve abnormalities in several brain structures, including the amygdala. To date, however, no study has used quantitative structural neuroimaging techniques to examine amygdalar anatomy in this disorder. Volumetric magnetic resonance imaging (MRI) studies of the amygdalas, hippocampi, and temporal lobes were conducted in 12 drug-free, symptomatic PD patients (six females and six males), and 12 case-matched healthy comparison subjects. Volumetric MRI data were normalized for brain size. PD patients were found to have smaller left-sided and right-sided amygdalar volumes than controls. No differences were found in either hippocampi or temporal lobes. These findings provide new evidence of changes in amygdalar structure in PD and warrant further anatomical and MRI brain studies of patients with this disorder. 相似文献
72.
Maria Giné-Garriga Carme Martin Carlos Martín Anna Puig-Ribera Juan José Antón Agustí Guiu Ana Cascos Rafel Ramos 《BMC public health》2009,9(1):31
Background
Declining physical activity is associated with a rising burden of global disease. There is little evidence about effective ways to increase adherence to physical activity. Therefore, interventions are needed that produce sustained increases in adherence to physical activity and are cost-effective. The purpose is to assess the effectiveness of a primary care physical activity intervention in increasing adherence to physical activity in the general population seen in primary care. 相似文献73.
74.
Bessy Benejam Juan Sahuquillo Maria Antonia Poca Laura Frascheri Elisabeth Solana Pilar Delgado Carme Junqué 《Journal of neurology》2009,256(7):1126-1133
Malignant middle cerebral artery (MMCA) infarction is associated with a mortality rate of 80% under conservative treatment.
Decompressive hemicraniectomy (DH) reduces mortality and improves the functional outcome of surviving patients. The purpose
of this study was to examine quality of life (QoL) and neurobehavioral deficits in patients with space-occupying infarctions
of the right- or left-sided hemisphere at 6 months after stroke. The Sickness Impact Profile (SIP) was used to assess QoL
in 19 out of 29 consecutive patients that underwent DH after a malignant MCA infarction (14 on the right and 5 on the left
hemisphere). Behavioral changes were evaluated with the Frontal Behavioral Inventory and the Beck Depression Inventory. Patients
and relatives were also asked if, knowing the present outcome, they would agree again, in retrospect, to a DH. Barthel Index
>60 was seen in 37% of our patients. Functional outcome was related to age. We found a higher reduction in the SIP’s physical
domain than in the psychosocial domain. Depressive symptoms were present in 50% of the patients. We didn’t find significant
differences in QoL or functional outcome between patients with right or left-sided infarctions. The most frequent neurobehavioral
symptoms were decreased speech output, apathy, reduced spontaneity and irritability. Most patients and their relatives would
again give consent to hemicraniectomy. The results show that younger patients had a significantly better outcome. QoL seems
to be acceptable in both left- and right-sided infarctions, and retrospective agreement to hemicraniectomy is high in both
patients and their relatives. 相似文献
75.
Giménez M Junqué C Vendrell P Caldú X Narberhaus A Bargalló N Falcón C Botet F Mercader JM 《NeuroImage》2005,25(2):561-569
Functional magnetic resonance imaging (fMRI) was used to map hippocampal activation during a declarative memory task in a sample of 14 adolescents with antecedents of prematurity (AP). The sample with AP was matched by age, sex and handedness with 14 full-term controls with no history of neurological or psychiatric illness. The target task consisted in learning 16 novel face-name pairs, and the control task involved the examination of two repeated face-name pairs. Stereological methods were also used to quantify hippocampal volumes. In both groups, we observed increased activation in the learning condition compared to the control task in the right fusiform gyrus and the left inferior occipital gyrus, but only premature subjects activated the hippocampus. Group comparison of the activation versus control conditions showed that prematures had greater activity in the right hippocampus than controls during the encoding of the word-face association. Volumetric analyses showed a significant left hippocampal volume loss in adolescents with AP. In addition, we found a significant positive correlation in the premature group between right hippocampal activation and face-name recognition. Functional MRI data also correlated with structural MRI data: right hippocampal activation correlated positively with right hippocampal volume. Our findings are consistent with previous studies of brain plasticity after focal lesions. Left hippocampal tissue loss may be related to an increase in contralateral brain activity, probably reflecting a compensatory mechanism. Our data also suggest that this plasticity is not enough to achieve normal performance. 相似文献
76.
Andrés Cabrera-León Antonio Daponte-Codina Inmaculada Mateo Elena Arroyo-Borrell Xavier Bartoll María José Bravo María Felicitas Domínguez-Berjón Gemma Renart Carlos Álvarez-Dardet Marc Marí-Dell’Olmo Julia Bolívar-Muñoz Marc Saez Vicenta Escribà-Agüir Laia Palència María José López Carme Saurina Vanessa Puig Unai Martín Mariola Bernal 《Gaceta sanitaria / S.E.S.P.A.S》2019,33(5):497
77.
78.
Cristina Sanchez‐Castaneda MSc Ramon Rene MD PhD Blanca Ramirez‐Ruiz PhD Jaume Campdelacreu MD PhD Jordi Gascon MD Carles Falcon PhD Matilde Calopa MD PhD Serge Jauma MD Montserrat Juncadella PhD Carme Junque PhD 《Movement disorders》2009,24(12):1740-1746
There is controversy regarding whether Dementia with Lewy Bodies (DLB) and Parkinson's disease with dementia (PDD) may or not be different manifestations of the same disorder. The purpose of the present study was to investigate possible correlations between brain structure and neuropsychological functions in clinically diagnosed patients with DLB and PDD. The study sample consisted of 12 consecutively referred DLB patients, 16 PDD patients, and 16 healthy control subjects recruited from an outpatient setting, who underwent MRI and neuropsychological assessment. Voxel‐based morphometry results showed that DLB patients had greater gray matter atrophy in the right superior frontal gyrus, the right premotor area and the right inferior frontal lobe compared to PDD. Furthermore, the anterior cingulate and prefrontal volume correlated with performance on the Continuous Performance Test while the right hippocampus and amygdala volume correlated with Visual Memory Test in the DLB group. In conclusion, DLB patients had more fronto‐temporal gray matter atrophy than PDD patients and these reductions correlated with neuropsychological impairment. © 2009 Movement Disorder Society 相似文献
79.
Naroa Ibarretxe‐Bilbao PhD Eduardo Tolosa MD Carme Junque PhD Maria‐Jose Marti MD 《Movement disorders》2009,24(Z2):S748-S753
Patients with Parkinson's disease (PD) may present impairment in cognitive functions even at early stages of the disease. When compared with the general population, their risk of dementia is five to six times higher. Recent investigations using structural MRI have shown that dementia in PD is related to cortical structural changes and that specific cognitive dysfunctions can be attributed to atrophy in specific structures. We review the structural MRI studies carried out in PD using either a manual region of interest (ROI) approach or voxel‐based morphometry (VBM). ROI studies have shown that hippocampal volume is decreased in patients with PD with and without dementia; in addition, hippocampal atrophy correlated with deficits in verbal memory. VBM studies have demonstrated that dementia in PD involves structural changes in limbic areas and widespread cortical atrophy. Findings in nondemented patients with PD are less conclusive, possibly because cognitively heterogeneous groups of patients have been studied. Patients with PD with cognitive impairment and/or visual hallucinations present greater brain atrophy than patients without these characteristics. These findings suggest that cortical atrophy is related to cognitive dysfunction in PD and precedes the development of dementia. Structural MRI might therefore provide an early marker for dementia in PD. © 2009 Movement Disorder Society 相似文献
80.
Ferré S Agnati LF Ciruela F Lluis C Woods AS Fuxe K Franco R 《Brain Research Reviews》2007,55(1):55-67
‘Local module’ is a fundamental functional unit of the central nervous system that can be defined as the minimal portion of one or more neurons and/or one or more glial cells that operates as an independent integrative unit. This review focuses on the importance of neurotransmitter receptor heteromers for the operation of local modules. To illustrate this, we use the striatal spine module (SSM), comprised of the dendritic spine of the medium spiny neuron (MSN), its glutamatergic and dopaminergic terminals and astroglial processes. The SSM is found in the striatum, and although aspects such as neurotransmitters and receptors will be specific to the SSM, some general principles should apply to any local module in the brain. The analysis of some of the receptor heteromers in the SSM shows that receptor heteromerization is associated with particular elaborated functions in this local module. Adenosine A2A receptor–dopamine D2 receptor–glutamate metabotropic mGlu5 receptor heteromers are located adjacent to the glutamatergic synapse of the dendritic spine of the enkephalin MSN, and their cross-talk within the receptor heteromers helps to modulate postsynaptic plastic changes at the glutamatergic synapse. A1 receptor–A2A receptor heteromers are found in the glutamatergic terminals and the molecular cross-talk between the two receptors in the heteromer helps to modulate glutamate release. Finally, dopamine D2 receptor–non-α7 nicotinic acetylcholine receptor heteromers, which are located in dopaminergic terminals, introduce the new concept of autoreceptor heteromer. 相似文献