全文获取类型
收费全文 | 980篇 |
免费 | 41篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 17篇 |
妇产科学 | 29篇 |
基础医学 | 146篇 |
口腔科学 | 5篇 |
临床医学 | 60篇 |
内科学 | 230篇 |
皮肤病学 | 8篇 |
神经病学 | 153篇 |
特种医学 | 17篇 |
外科学 | 75篇 |
综合类 | 3篇 |
预防医学 | 216篇 |
眼科学 | 3篇 |
药学 | 30篇 |
肿瘤学 | 32篇 |
出版年
2023年 | 2篇 |
2022年 | 8篇 |
2021年 | 24篇 |
2020年 | 11篇 |
2019年 | 26篇 |
2018年 | 17篇 |
2017年 | 24篇 |
2016年 | 12篇 |
2015年 | 16篇 |
2014年 | 41篇 |
2013年 | 51篇 |
2012年 | 80篇 |
2011年 | 81篇 |
2010年 | 47篇 |
2009年 | 59篇 |
2008年 | 58篇 |
2007年 | 83篇 |
2006年 | 74篇 |
2005年 | 50篇 |
2004年 | 60篇 |
2003年 | 44篇 |
2002年 | 50篇 |
2001年 | 8篇 |
2000年 | 11篇 |
1999年 | 8篇 |
1998年 | 6篇 |
1997年 | 7篇 |
1996年 | 3篇 |
1995年 | 5篇 |
1994年 | 2篇 |
1993年 | 5篇 |
1992年 | 2篇 |
1991年 | 8篇 |
1990年 | 5篇 |
1989年 | 5篇 |
1988年 | 3篇 |
1986年 | 2篇 |
1984年 | 4篇 |
1983年 | 1篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1977年 | 3篇 |
1976年 | 6篇 |
排序方式: 共有1025条查询结果,搜索用时 15 毫秒
31.
Úrsula Cataln Anna Pedret Silvia Yuste Laura Rubi Carme Piol Berner Andre Sandoval-Ramírez Judit Companys Elisabet Foguet Pol Herrero Núria Canela Maria-Jose Motilva Rosa Sol 《Nutrients》2022,14(5)
The impact of a red-fleshed apple (RFA) rich in anthocyanins (ACNs), a white-fleshed apple (WFA) without ACNs, and an extract infusion from Aronia fruit (AI) equivalent in dose of cyanidin-3-O-galactoside (main ACN) as RFA was determined by the proteome profile of aorta and heart as key cardiovascular tissues. Hypercholesterolaemic Wistar rats were separated into six groups (n = 6/group; three males and three females) and the proteomic profiles were analyzed using nanoliquid chromatography coupled to mass spectrometry. No adverse events were reported and all products were well tolerated. RFA downregulated C1QB and CFP in aorta and CRP in heart. WFA downregulated C1QB and CFP in aorta and C9 and C3 in aorta and heart, among other proteins. AI downregulated PRKACA, IQGAP1, and HSP90AB1 related to cellular signaling. Thus, both apples showed an anti-inflammatory effect through the complement system, while RFA reduced CRP. Regardless of the ACN content, an apple matrix effect was observed that involved different bioactive components, and inflammatory proteins were reduced. 相似文献
32.
Eva Bernal Antoni Bayés-Genís Albert Ariza-Solé Francesc Formiga Maria T. Vidán Luis Alberto Escobar-Robledo Jaime Aboal Lídia Alcoberro Carme Guerrero Iván Ariza-Segovia Ana Hernández de Benito Pau Vilardell José Carlos Sánchez-Salado Victoria Lorente Antoni Bayés de Luna Manuel Martinez-Sellés 《Journal of electrocardiology》2018,51(4):747
33.
Herena Eixarch Laura Calvo-Barreiro Carme Costa Gemma Reverter-Vives Mireia Castillo Vanessa Gil Jos Antonio Del Río Xavier Montalban Carmen Espejo 《Neurotherapeutics》2020,17(4):1988
Bone morphogenetic proteins (BMPs) are secreted growth factors that belong to the transforming growth factor beta superfamily. BMPs have been implicated in physiological processes, but they are also involved in many pathological conditions. Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS); however, its etiology remains elusive. Some evidence points to BMPs as important players in the pathogenesis of inflammatory and autoimmune disorders. In the present work, we studied the expression of BMP2, BMP4, BMP5, BMP6, BMP7, BMP type II receptor, and noggin in the immune system during different phases of experimental autoimmune encephalomyelitis (EAE). Major changes in the expression of BMPs took place in the initial phases of EAE. Indeed, those changes mainly affected BMP6 (whose expression was abrogated), BMP2, and BMP7 (whose expression was increased). In addition, we showed that in vivo inhibition of the BMP signaling pathway with small molecules ameliorated the already established clinical symptoms of EAE, as well as the CNS histopathological features. At the immune level, we observed an expansion of plasmacytoid dendritic cells (pDCs) in mice treated with small molecules that inhibit the BMP signaling pathway. pDCs could play an important role in promoting the expansion of antigen-specific regulatory T cells. Altogether, our data suggest a role for BMPs in early immune events that take place in myelin oligodendrocyte glycoprotein (MOG)-induced EAE. In addition, the clinical outcome of the disease was improved when the BMP signaling pathway was inhibited in mice that presented established EAE symptoms.Electronic supplementary materialThe online version of this article (10.1007/s13311-020-00885-8) contains supplementary material, which is available to authorized users. 相似文献
34.
35.
36.
Antoni Rosell Rosa López-Lisbona Noelia Cubero Carme Obiols Francisco Rivas Jordi Dorca 《Archivos de bronconeumologia》2011,47(7):371-373
The persistent air leaks due to alveolopleural fistula is not an uncommon complication of pneumothorax, particularly secondary ones. Unidirectional flow endobronchial valves initially designed for lung volume reduction are the latest tool in the therapeutic armamentarium.We present a patient with chronic obstructive pulmonary disease (COPD) with a persistent pneumothorax in spite of three pleurodesis, which was able to be resolved with the placement of two IBV? valves. 相似文献
37.
38.
Pregnancy planning allows women to better control their life trajectory and contributes to the future child’s health and development.
Many studies that have analyzed socioeconomic inequalities in unintended pregnancy only took into account those pregnancies
ending in births. Few of them that analyzed unintended pregnancy, including both induced abortion and births, and its socioeconomic
determinants, concluded that unintended pregnancy is more frequent in young, poor, or unmarried women. These inequalities
have been poorly studied in Europe, especially in the southern European context. The aim of the present study is to describe
socioeconomic inequalities in unintended pregnancy and in abortion decision in Barcelona, Spain. The major findings are that
unintended pregnancies accounted for 41% of total pregnancy and of these, 60% ended in abortion. From all pregnancies, the
proportion of induced abortion reached 25.6%. Compared to women with university studies, those with primary education uncompleted
had more unintended pregnancies (OR = 7.22). When facing an unintended pregnancy, women of lower socioeconomic position are
more likely to choose induced abortion, although this is not the case among young or single women. This study reveals deep
socioeconomic inequalities in unintended pregnancies and abortion decision in Barcelona, Spain, where the birth rate is very
low and the abortion rate is rising. Women in low socioeconomic positions have many more unintended pregnancies than better
educated women. Except for young or single women, the lower the socioeconomic position, the higher the proportion of women
who choose an induced abortion when facing an unintended pregnancy.
Font-Ribera, Pérez, Salvador, and Borrell are with the Health Information Service, Agency of Public Health of Barcelona, Barcelona,
Spain; Pérez and Borrell are with the University Pompeu Fabra, Barcelona, Spain; Pérez and Borrell are with the CIBER in Epìdemiology
and Public Health (CIBERESP), Barcelona, Spain; Pérez is with the Agency of Public Health of Barcelona, Barcelona, Spain. 相似文献
39.
40.
Parahippocampal gray matter density in panic disorder: a voxel-based morphometric study 总被引:4,自引:0,他引:4
Massana G Serra-Grabulosa JM Salgado-Pineda P Gastó C Junqué C Massana J Mercader JM 《The American journal of psychiatry》2003,160(3):566-568
OBJECTIVE: The authors examined possible cerebral gray matter abnormalities in patients with panic disorder. METHOD: Gray matter concentration in 18 panic disorder outpatients and 18 healthy subjects was compared by using a voxel-based morphometry approach. RESULTS: Gray matter density of the left parahippocampal gyrus was significantly lower in patients with panic disorder compared with healthy subjects. CONCLUSIONS: This result provides further support for the involvement of the parahippocampal area in the pathophysiology of panic disorder. 相似文献