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排序方式: 共有1070条查询结果,搜索用时 15 毫秒
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Islet cell transplantation: the future? 总被引:3,自引:0,他引:3
Thierry Berney Camillo Ricordi 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2000,385(6):373-378
BACKGROUND: Islet of Langerhans' cell transplantation is a promising strategy for the treatment of type-1 diabetes mellitus. Results of this procedure have yet to match those of whole organ pancreas transplantation, but are rapidly improving, as witnessed by increasing rates of insulin independence and graft function (i.e., C-peptide production) after islet transplantation. DISCUSSION: Identification of obstacles to the success of islet transplantation, such as primary nonfunction, immunosuppression-related metabolic workload, or recurrence of autoimmunity, will allow the development of new strategies tailored to overcome them. In particular, novel immunosuppressive protocols, with or without the aim of inducing tolerance, and immunoisolation devices are reaching the stage of clinical applicability. Finally, several strategies, such as utilization of porcine xenogeneic islets or genetically engineered beta-cell lines, or in vitro expansion of cultured beta-cells could theoretically expand indefinitely the pool of islet tissue for transplantation. 相似文献
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One-year migraine prevalence rates in the general population for Western countries vary from 4% to 9% in men and from 11% to 25% in women. Non-Western countries report lower figures. Incidence rates for people under 30 years of age vary from 1.5 to 6 per 1000 person-years in men and from 3 to 24 per 1000 person-years in women. Data on the prevalence of migraine in general, on the gender ratio and on the variations in prevalence in the different age ranges are fairly comparable and can be regarded as very close to reality. On the contrary, data on the incidence of migraine, on the prevalence of different migraine subtypes, such as migraine with aura and the so-called migrainous disorder, and on the frequency of migraine attacks show a striking discordance that somewhat undermines their reliability. The main critical points in prevalence and incidence studies are migraine definition and the methodological approaches used for case screening. Even if International Headache Society (IHS) classification is certainly an improvement over previous tools used in epidemiological studies, the diagnostic criteria for migraine without aura are quite scanty and not easily remembered by subjects belonging to the general population, and those for migraine with aura appear not only difficult to translate for use in a questionnaire or an interview, but also too loose. In particular, the lack of any low-end limit for aura duration may cause an overestimation of migraine with aura prevalence. 相似文献
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Marcelo Frigero Solange Almeida dos Santos Andrey Jorge Serra Caroline dos Santos Monteiro Machado Leslie Andrews Portes Paulo José Ferreira Tucci Flavio Silva Ernesto Cesar Leal-Junior Paulo de Tarso Camillo de Carvalho 《Lasers in medical science》2018,33(8):1781-1790
This study aimed to determine whether photobiomodulation therapy (PBMT) in diabetic rats subjected to high-intensity exercise interferes with the expression of the oxidative stress marker in the gastrocnemius muscle. Twenty-four male Wistar rats were included in this study comprising 16 diabetic and eight control rats. The animals were allocated into three groups—control, diabetic fatigue, and diabetic PBMT fatigue groups. Diabetes was induced via the intraperitoneal administration of streptozotocin (50 mg/kg). We subsequently assessed blood lactate levels and PBMT. The animals of the diabetic fatigue group PBMT were irradiated before the beginning of the exercises, with dose of 4 J and 808 nm, were submitted to treadmill running with speed and gradual slope until exhaustion, as observed by the maximum volume of oxygen and lactate level. The animals were euthanized and muscle tissue was removed for analysis of SOD markers, including catalase (CAT), glutathione peroxidase (GPx), and 2-thiobarbituric acid (TBARS) reactive substances. CAT, SOD, and GPx activities were significantly higher in the diabetic PBMT fatigue group (p?<?0.05) than in the diabetic fatigue group. Outcomes for the diabetic PBMT fatigue group were similar to those of the control group (p?>?0.05), while their antioxidant enzymes were significantly higher than those of the diabetic fatigue group. PBMT mitigated the TBARS concentration (p?>?0.05). PBMT may reduce oxidative stress and be an alternative method of maintaining physical fitness when subjects are unable to perform exercise. However, this finding requires further testing in clinical studies. 相似文献
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Piero Serra Camillo Brandimarte Piero Martino Franco Mandelli 《International Journal of Clinical & Laboratory Research》1976,6(4):319-325
Summary This report is based on experience over the last 5 years in the diagnosis and treatment of infections in 200 acute leukemic
patients hospitalized in the Institute of Haematology, University of Rome. The relevant clinical and laboratory findings are
discussed in relation to the diagnosis of secondary infections. Most of the febrile episodes were associated with infection.
The frequently rapid development of the infections in these patients requires empirical antibiotic treatment. The best results
were obtained when the combinations carbenicillin-cephalothin-gentamicin (success rate of 65 %), and carbenicillin-cephalothin-gentamicin-lyncomycin-methicillin
(success rate of 62 %), were used as empirical therapy. 相似文献
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Bernardo Rocco Barbara A. Jereczek‐Fossa Deliu‐Victor Matei Fabrizio Verweij Luigi Santoro Andrea Vavassori Juan Camillo Ospina Francisco Cedeira Mario Ciocca Roberto Orecchia Ottavio De Cobelli 《BJU international》2009,104(11):1624-1630