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计算机程序化的初均速法测定双黄连注射液的稳定性 总被引:2,自引:0,他引:2
用计算机程序化的初均速法,测定了双黄连溶液中3种主要成分——绿原酸、黄苓甙、连翘甙的活化能及室温贮存期。该方法简便、快速、结果准确。对临床应用有一定价值。 相似文献
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G. Bolis G. Bortolozzi G. Carinelli M. D'Incalci F. Gramellini L. Morasca C. Mangioni 《Cancer chemotherapy and pharmacology》1980,4(2):129-132
Summary After intensive staging 74 ovarian cancer patients were randomized to two arms balanced for stage and post-surgery residual tumor. The two regimens were CTX 100 mg/day continuously and ADM 50 mg/m2 IV every 4 weeks plus CTX 100 mg/day. The response rates were respectively 42% and 52%. Median survival times were 13 and 14 months. The incidence of side effects was significantly higher in the combination-treatment arm. No other statistical differences were found. 相似文献
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B Mandelli F Polatti P F Bolis 《Clinical and experimental obstetrics & gynecology》1985,12(1-2):16-20
In the capillary areas erythrocyte deformability plays a significant part in determining perfusion and exchanges between blood and tissues. In fact, in the capillary areas, when the perfusion pressure diminishes, the erythrocytes no longer follow their linear trajectory movement but proceed randomly, thus favouring the phenomena of aggregation. In pregnancy we find a physiological haemodilution consequent upon the proportionally greater increase in the plasmatic volume in respect to the cellular one. In physiological conditions such haemodilution reaches equilibrium between the plastic and cellular components which, according to data shown would favor erythrocytic distortion and consequently the perfusion of the peripheral areas. The deformability expressed by VRBC increases up to the 26th-28th week of pregnancy, then remains constant until full term. 相似文献
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We describe a middle-aged Chinese systemic lupus erythematosus (SLE) patient developing steroid refractory and transfusion dependent red cell aplasia. Oral danazol 200 mg twice per day was started together with low-dose prednisolone therapy. There was no further recurrence of anemia 1 month after this combined therapy. 相似文献
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Trimbos JB Parmar M Vergote I Guthrie D Bolis G Colombo N Vermorken JB Torri V Mangioni C Pecorelli S Lissoni A Swart AM;International Collaborative Ovarian Neoplasm ;European Organisation for Research Treatment of Cancer Collaborators-Adjuvant ChemoTherapy un Ovarian Neoplasm 《Journal of the National Cancer Institute》2003,95(2):105-112
BACKGROUND: Adjuvant chemotherapy has been suggested as a possible strategy to improve survival in women with early-stage ovarian cancer; however, all randomized studies to date have been too small to answer this question reliably. METHODS: We performed a preplanned combined analysis of two parallel randomized clinical trials (International Collaborative Ovarian Neoplasm 1 [ICON1] and Adjuvant ChemoTherapy In Ovarian Neoplasm [ACTION]) in early-stage ovarian cancer that compared platinum-based adjuvant chemotherapy with observation following surgery. Between November 1990 and January 2000, 925 patients (477 in ICON1 and 448 in ACTION) who had surgery for early-stage ovarian cancer were randomly assigned to receive platinum-based adjuvant chemotherapy (n = 465) or observation (n = 460) until chemotherapy was indicated. Kaplan-Meier analysis was used to compare overall and recurrence-free survival by treatment allocation. In subgroup analyses of pretreatment age, tumor stage, histologic cell type, and differentiation grade, the differences in relative size of effect were tested using a chi-square test for interaction or a chi-square test for trend. All tests of statistical significance were two-sided. RESULTS: After a median follow-up of over 4 years, 245 patients had died or had a recurrence (ICON1: 133, ACTION: 112). Overall survival at 5 years was 82% in the chemotherapy arm and 74% in the observation arm (difference = 8% [95% confidence interval (CI) = 2% to 12%]; hazard ratio [HR] = 0.67, 95% CI = 0.50 to 0.90; P =.008). Recurrence-free survival at 5 years was also better in the adjuvant chemotherapy arm than it was in the observation arm (76% versus 65%, difference = 11% [95% CI = 5% to 16%]; HR = 0.64, 95% CI = 0.50 to 0.82; P =.001). Subgroup analyses provided no evidence of a difference in the size of effect of chemotherapy on survival in any pretreatment subcategory. CONCLUSIONS: Platinum-based adjuvant chemotherapy improved overall survival and recurrence-free survival at 5 years in this combined group of patients with early-stage ovarian cancer defined by the inclusion criteria of the ICON1 and ACTION trials. 相似文献