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91.
Surgical Decision Making in the BRCA‐Positive Population: Institutional Experience and Comparison with Recent Literature 下载免费PDF全文
Teresa Flippo‐Morton MD FACS Kendall Walsh CCRP Karinn Chambers MD Lisa Amacker‐North MS CGC Brook White MS CGC Terry Sarantou MD FACS Danielle M. Boselli MS Richard L. White MD FACS Jr. 《The breast journal》2016,22(1):35-44
A retrospective study was performed to document the uptake and extent of surgical intervention in patients with a known mutation in the BRCA1/2 genes and associated outcomes. Data were collected retrospectively on BRCA‐positive patients with and without cancer at the time of genetic testing. Our findings were compared to those published in the current literature. Of patients with cancer at testing, 61% chose bilateral mastectomies. Of patients without cancer, 54% chose risk‐reducing surgery (RRS) including risk‐reducing mastectomy (RRM), risk‐reducing salpingo‐oophorectomy (RRSO), or both. Time to surgery was significantly shorter to RRSO than to RRM. The literature suggests and our data support that acceptance of RRM in the BRCA‐positive population has gradually increased over time. Consistently high rates of RRSO uptake and short intervals from time‐of‐testing to RRSO demonstrate that RRSO is still more acceptable to this population than RRM. 相似文献
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Vida Henderson PhD PharmD MPH MFA Ifeanyi Beverly Chukwudozie MBA MPH DeLawnia Comer-Hagans PhD Vickii Coffey PhD MSA Giesela Grumbach PhD MSW Shirley Spencer PhD MSN Carolyn Rodgers PhD MPH MHS MCHES Ravneet Kaur DrPH MBA Jennifer Newsome MS Lara Balay MS Ed MS CGC Tara Maga PhD MS CGC Le’Chaun Kendall MPH Catherine Balthazar PhD Karriem Watson DHS MS MPH Robert Winn MD Angela Odoms-Young PhD Kent F. Hoskins MD 《Cancer》2021,127(14):2535-2544
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Yongjin Yoo BS Jane Jung BS Yoo‐Na Lee BS Youngha Lee MS Hyosuk Cho BS Eunjung Na BS JeaYeok Hong BS Eunjin Kim MS Jin Sook Lee MD PhD Je Sang Lee MD Chansik Hong PhD Sang‐Yoon Park PhD Jinhong Wie PhD Kathryn Miller CGC Natasha Shur MD Cheryl Clow RN Roseànne S. Ebel MS Suzanne D. DeBrosse MD Lindsay B. Henderson PhD Rebecca Willaert MS MA CGC Christopher Castaldi MS Irina Tikhonova MS Kaya Bilgüvar MD Shrikant Mane PhD Ki Joong Kim MD PhD Yong Seung Hwang MD PhD Seok‐Geun Lee PhD Insuk So MD PhD Byung Chan Lim MD PhD Hee‐Jung Choi PhD Jae Young Seong PhD Yong Beom Shin MD PhD Hosung Jung PhD Jong‐Hee Chae MD PhD Murim Choi PhD 《Annals of neurology》2017,82(3):466-478
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Risa Isonaka PhD David S. Goldstein MD PhD William Zhu BS Esther Yoon BS Debra Ehrlich MD MS Alice B. Schindler MS CGC Angela D. Kokkinis BSN RN Marya S. Sabir BS Sonja W. Scholz MD PhD Sara Bandres-Ciga PhD Cornelis Blauwendraat PhD Pedro Gonzalez-Alegre MD PhD Grisel Lopez MD Ellen Sidransky MD Derek P. Narendra MD PhD 《Movement disorders》2021,36(10):2346-2357
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Sarah Crimmins DO Sudhir Vashit MD Lauren Doyle CGC Chris Harman MD Ozhan Turan MD PhD Sifa Turan MD RDMS 《Journal of clinical ultrasound : JCU》2017,45(3):168-170
A 27‐week fetus evaluated for bradycardia and hydrops was found to have anti‐SSA‐negative 2° atrioventricular block and ventricular tachycardia. A presumptive diagnosis of fetal long QT syndrome was made. Transplacental pharmacotherapy with intravenous magnesium and lidocaine restored sinus rhythm. At 30 6/7 weeks, the infant was delivered due to premature labor. Despite postnatal treatment with mexiletine and propranolol, she developed torsades de pointes. Ultimately, a de novo KCNH2 G628S mutation was diagnosed. She received an implantable cardiac defibrillator at 5 months of age. Early diagnosis and a multidisciplinary approach allowed successful in utero treatment and anticipatory postnatal management. © 2016 Wiley Periodicals, Inc. J Clin Ultrasound 45 :168–170, 2017 相似文献
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Erin E. Salo‐Mullen MS CGC Eileen M. O'Reilly MD David P. Kelsen MD Asad M. Ashraf BA Maeve A. Lowery MD Kenneth H. Yu MD Diane L. Reidy MD Andrew S. Epstein MD Anne Lincoln MS Amethyst Saldia BS Lauren M. Jacobs BS Rohini Rau‐Murthy BA Liying Zhang MD PhD Robert C. Kurtz MD Leonard Saltz MD Kenneth Offit MD MPH Mark E. Robson MD Zsofia K. Stadler MD 《Cancer》2015,121(24):4382-4388