全文获取类型
收费全文 | 1621篇 |
免费 | 138篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 15篇 |
儿科学 | 24篇 |
妇产科学 | 26篇 |
基础医学 | 246篇 |
口腔科学 | 131篇 |
临床医学 | 161篇 |
内科学 | 319篇 |
皮肤病学 | 44篇 |
神经病学 | 136篇 |
特种医学 | 56篇 |
外国民族医学 | 1篇 |
外科学 | 180篇 |
综合类 | 3篇 |
预防医学 | 154篇 |
眼科学 | 22篇 |
药学 | 111篇 |
中国医学 | 16篇 |
肿瘤学 | 123篇 |
出版年
2023年 | 37篇 |
2022年 | 68篇 |
2021年 | 110篇 |
2020年 | 73篇 |
2019年 | 92篇 |
2018年 | 99篇 |
2017年 | 73篇 |
2016年 | 78篇 |
2015年 | 72篇 |
2014年 | 99篇 |
2013年 | 93篇 |
2012年 | 132篇 |
2011年 | 120篇 |
2010年 | 59篇 |
2009年 | 49篇 |
2008年 | 61篇 |
2007年 | 61篇 |
2006年 | 59篇 |
2005年 | 40篇 |
2004年 | 35篇 |
2003年 | 30篇 |
2002年 | 24篇 |
2001年 | 3篇 |
2000年 | 11篇 |
1999年 | 8篇 |
1998年 | 7篇 |
1996年 | 5篇 |
1994年 | 5篇 |
1993年 | 5篇 |
1992年 | 12篇 |
1991年 | 6篇 |
1990年 | 11篇 |
1989年 | 9篇 |
1988年 | 11篇 |
1987年 | 14篇 |
1986年 | 11篇 |
1985年 | 7篇 |
1984年 | 3篇 |
1983年 | 12篇 |
1982年 | 4篇 |
1980年 | 6篇 |
1979年 | 5篇 |
1978年 | 7篇 |
1977年 | 4篇 |
1974年 | 8篇 |
1973年 | 4篇 |
1972年 | 7篇 |
1971年 | 3篇 |
1970年 | 2篇 |
1966年 | 2篇 |
排序方式: 共有1768条查询结果,搜索用时 31 毫秒
101.
Iara Buriola Trevisan Ubiratan de Paula Santos Marceli Rocha Leite Aline Duarte Ferreira Bruna Spolador de Alencar Silva Ana Paula Coelho Figueira Freire Gabriel Faustino Santa Brigida Ercy Mara Cipulo Ramos Dionei Ramos 《Revista brasileira de otorrinolaringologia (English ed.)》2019,85(3):337-343
IntroductionBurnt sugarcane harvesting requires intense physical exertion in an environment of high temperature and exposure to particulate matter.ObjectiveTo evaluate the effects of burnt sugarcane harvesting on rhinitis symptoms and inflammatory markers in sugarcane workers.MethodsA total of 32 male sugarcane workers were evaluated with questionnaire for rhinitis symptoms, and for inflammatory markers on peripheral blood and nasal lavage, in the non-harvesting, and 3 and 6 months into the sugarcane harvesting period. Weather data and particulate matter fine concentrations were measured in the same day.ResultsThe particulate matter concentrations in sugarcane harvesting were 27 (23–33 μg/m3), 112 (96–122 μg/m3), and 63 (17–263 μg/m3); 24 h temperatures were 32.6 (25.4–37.4 °C), 32.3 (26.7–36.7 °C) and 29.7 (24.1–34.0 °C) and relative humidities were 45.4 (35.0–59.7%), 47.9 (39.1–63.0%), and 59.9 (34.7–63.2%) in the non-harvesting period, three and 6 months of the harvesting period. The age was 37.4 ± 10.9 years. The prevalence of rhinitis symptoms was significantly higher at 3 months of the harvesting period (53.4%), compared to non-harvesting period (26.7%; p = 0.039) and at 6 months into the harvesting period (20%; p = 0.006). Concentrations of interleukin 6 (IL-6) in nasal lavage increased after 3 months of the harvesting period compared to the non-harvesting period (p = 0.012). The presence of rhinitis symptoms, after 3 months of the harvesting period, was directly associated with blood eosinophils and inversely associated with neutrophils.ConclusionsAfter 3 months of work in burnt sugarcane harvesting the prevalence of rhinitis symptoms and IL-6 in nasal lavage increased. Furthermore, eosinophil counts were directly associated with the rhinitis symptoms in the period of higher concentration of particulate matter. 相似文献
102.
Bruna Neroni Maria Antonella Zingaropoli Giulia Radocchia Maria Rosa Ciardi Luciana Mosca Fabrizio Pantanella Serena Schippa 《Oncology Letters》2022,23(4)
Violacein is a natural pigment, a pyrrolidone, and a bisindole derived from the condensation of two tryptophan molecules, which gives a blue violet color to several gram-negative violacein-producing bacteria. Violacein production provides a competitive advantage against antagonistic species or predators. In addition, the compound has antibacterial, antifungal, antiviral, and antioxidant activities. Several studies on colon, breast, and head and neck cancer lines have already demonstrated the anti-proliferative potential of violacein. Bladder cancer is one of the most common types of cancer in urology. The therapeutic approach is mainly based on surgery, chemotherapy, and immunotherapy. The aim of the present study was to evaluate the anti-proliferative activity of violacein against the human bladder cancer cell lines, HTB4 (T24) and HTB9 (5637), using low-grade and high-grade transitional cell carcinoma models, respectively, which has never been assayed before. For this purpose, the potential violacein anti-proliferative effect on T24 and 5637 cells was evaluated by studying the cell viability, proliferation, cell cycle, and caspase-3 activation. The results showed that violacein had anti-proliferative activity in the two cell lines, which was greater for the second-stage bladder cancer cell line (5637), and a different mode of action against the two cell lines. 相似文献
103.
Investigation of the clinical features of geographic tongue: unveiling its relationship with oral psoriasis
下载免费PDF全文
![点击此处可从《International journal of dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
104.
105.
Langlois RG Trebes JE Dalmasso EA Ying Y Davies RW Curzi MP Colston BW Turteltaub KW Perkins J Chromy BA Choi MW Murphy GA Fitch JP McCutchen-Maloney SL 《American journal of nephrology》2004,24(2):268-274
BACKGROUND: Serum protein profiling patterns can reflect the pathological state of a patient and therefore may be useful for clinical diagnostics. Here, we present results from a pilot study of proteomic expression patterns in hemodialysis patients designed to evaluate the range of serum proteomic alterations in this population. METHODS: Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF-MS) was used to analyze serum obtained from patients on periodic hemodialysis treatment and healthy controls. Serum samples from patients and controls were first fractionated into six eluants on a strong anion exchange column, followed by application to four array chemistries representing cation exchange, anion exchange, metal affinity and hydrophobic surfaces. A total of 144 SELDI-TOF-MS spectra were obtained from each serum sample. RESULTS: The overall profiles of the patient and control samples were consistent and reproducible. However, 30 well-defined protein differences were observed; 15 proteins were elevated and 15 were decreased in patients compared to controls. Serum from 1 patient exhibited novel protein peaks suggesting possible additional changes due to a secondary disease process. CONCLUSION: SELDI-TOF-MS demonstrated consistent serum protein profile differences between patients and controls. Similarity in protein profiles among dialysis patients suggests that patient physiological responses to end-stage renal disease and/or dialysis therapy have a major effect on serum protein profiles. 相似文献
106.
107.
108.
109.
Julien Totti Bastos Camila Roos Mariano da Rocha Bruno Messias Pires de Freitas Leonardo Gonçalves Bravo Bruna Souza Felix Bravo 《Journal of cosmetic and laser therapy》2017,19(5):256-258
Vascular lesions such as hemangiomas can be found in the oral cavity. Some therapeutic modalities can be used in the treatment of these lesions and Nd:YAG 1064 nm long pulse laser shows good results with easy application, fewer complications and satisfactory results. This study describes the technique and outcome of a case of hemangioma located on the tongue treated with Nd:YAG laser. 相似文献
110.
Karen Leslie Stephanie Jeanneret Manning Catherine Maser Deirdre Snelgrove Tiffany Thornton Andrea Wills Bruna Brands 《International journal of mental health and addiction》2016,14(2):111-119
Alcohol and substance abuse in the adolescent population is a major health concern with a number of harms known to be associated with high levels of use. Few studies report on long-term health status of youth who have received treatment for a substance abuse problem during adolescence. This study aimed to describe the long-term status of a cohort of adolescents who received treatment in an intensive day treatment program situated in a tertiary care paediatric hospital. Youth participated in an interview that collected data using both standardized screening tools (GAIN-SS, AUDIT, CUDIT, DUI) as well as closed and open ended questions about education, employment, and physical and mental health status. Young adults in this sample continue to use alcohol and cannabis, with a proportion reporting problematic use. Their academic achievement is close to expected for their age group. They report concurrent mental health disorders; and as a cohort, access the health care system for both acute and chronic health conditions more than their contemporaries. These findings support the inclusion of academic, mental health and medical components in programs for adolescents with substance abuse, in order to address a broad range of determinants of health outcomes. 相似文献