全文获取类型
收费全文 | 25002篇 |
免费 | 1952篇 |
国内免费 | 102篇 |
专业分类
耳鼻咽喉 | 293篇 |
儿科学 | 729篇 |
妇产科学 | 461篇 |
基础医学 | 2830篇 |
口腔科学 | 485篇 |
临床医学 | 2575篇 |
内科学 | 5452篇 |
皮肤病学 | 400篇 |
神经病学 | 2442篇 |
特种医学 | 749篇 |
外国民族医学 | 2篇 |
外科学 | 3910篇 |
综合类 | 564篇 |
一般理论 | 26篇 |
预防医学 | 2126篇 |
眼科学 | 657篇 |
药学 | 1633篇 |
中国医学 | 34篇 |
肿瘤学 | 1688篇 |
出版年
2022年 | 201篇 |
2021年 | 441篇 |
2020年 | 265篇 |
2019年 | 422篇 |
2018年 | 463篇 |
2017年 | 350篇 |
2016年 | 337篇 |
2015年 | 455篇 |
2014年 | 620篇 |
2013年 | 965篇 |
2012年 | 1416篇 |
2011年 | 1394篇 |
2010年 | 826篇 |
2009年 | 731篇 |
2008年 | 1281篇 |
2007年 | 1402篇 |
2006年 | 1421篇 |
2005年 | 1407篇 |
2004年 | 1330篇 |
2003年 | 1249篇 |
2002年 | 1205篇 |
2001年 | 392篇 |
2000年 | 344篇 |
1999年 | 384篇 |
1998年 | 300篇 |
1997年 | 253篇 |
1996年 | 262篇 |
1995年 | 212篇 |
1994年 | 185篇 |
1993年 | 174篇 |
1992年 | 273篇 |
1991年 | 237篇 |
1990年 | 276篇 |
1989年 | 205篇 |
1988年 | 232篇 |
1987年 | 222篇 |
1986年 | 208篇 |
1985年 | 206篇 |
1984年 | 224篇 |
1983年 | 223篇 |
1982年 | 228篇 |
1981年 | 211篇 |
1980年 | 219篇 |
1979年 | 214篇 |
1978年 | 170篇 |
1977年 | 138篇 |
1976年 | 146篇 |
1975年 | 128篇 |
1974年 | 156篇 |
1973年 | 133篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
52.
Influence of parainfluenza-1 respiratory tract viral infection on endothelin receptor-effector systems in mouse and rat tracheal smooth muscle. 下载免费PDF全文
P. G. Knott P. J. Henry A. S. McWilliam P. J. Rigby L. B. Fernandes R. G. Goldie 《British journal of pharmacology》1996,119(2):291-298
1. In this study we have compared the effects of parainfluenza-1 respiratory tract viral infection on the density and function of ETA and ETB receptors in rat and mouse tracheal airway smooth muscle. 2. The bronchoconstrictor effect of inhaled methacholine was significantly enhanced in virus-infected rats, at both 4 and 12 days post-inoculation. That is, the concentration of methacholine causing an increase in resistance of 100% (PC100 methacholine) was significantly lower in virus-infected animals at both 4 and 12 days post-inoculation (n = 6-8; P < 0.05). 3. Total specific binding of [125I]-endothelin-1 and the relative proportions of ETA and ETB binding sites for [125I]-endothelin-1 were assessed in tracheal airway smooth muscle in parainfluenza-1-infected rats and mice at days 2, 4 and 12 post-inoculation using the ligands BQ-123 (1 microM; ETA receptor-selective) and sarafotoxin S6c (100 nM; ETB receptor-selective). Total specific binding in mice was significantly reduced at day 2 post-inoculation (n = 5; P < 0.05) but not at days 4 and 12 post-inoculation (n = 5). In control mice, the proportions of ETA and ETB binding sites were 53%:47% at day 2 and 43%:57% at day 4 and these were significantly altered by parainfluenza-1 infection such that, the ratios were 81%:19% at day 2 and 89%:11% at day 4 (P < 0.05). By day 12 post-inoculation, the proportion of ETA and ETB binding sites in tracheal smooth muscle from mice infected with parainfluenza-1 was not significantly different from control. In rat tracheal airway smooth muscle, neither total specific binding nor the ETA and ETB binding site ratio (64%:36%) were significantly altered in virus-inoculated rats at days 2, 4 or 12 post-inoculation (n = 5). 4. Parainfluenza-1 infection in mice had no effect on the sensitivity or maximal contractile effect of endothelin-1 in tracheal smooth muscle at days 2, 4 or 12 post-inoculation (n = 4). In contrast, contraction in response to the ETB receptor-selective agonist sarafotoxin S6c was attenuated by 39% at day 2 and by 93% at day 4 post-inoculation (P < 0.05). However, by day 12 post-inoculation, contractions to sarafotoxin S6c were not significantly different between control and virus-infected mice. In parainfluenza-1-infected rats, there were small but significant reductions in the sensitivity to carbachol, endothelin-1 and sarafotoxin S6c whilst the maximal responses to the highest concentrations of these agonists were not significantly altered by virus infection (n = 8). 5. BQ-123 (3 microM) had no significant effect on cumulative concentration-effect curves to endothelin-1 in tracheal preparations from control mice (n = 4) or parainfluenza-1-infected rats (n = 8). In contrast, in tissues taken from virus-infected mice at day 4 post-inoculation, BQ-123 caused a marked 9.6 fold rightward shift in the concentration-effect curve to endothelin-1 (n = 4). 6. In summary, we have demonstrated that parainfluenza-1 infection in mice transiently reduced the density of tracheal airway smooth muscle ETB receptors and this was reflected in reduced responsiveness to the ETB receptor-selective agonist sarafotoxin S6c. In contrast, whilst parainfluenza-1 infection in rats was associated with the pathological features and bronchial hyperresponsiveness common to respiratory tract viral infection, there was no selective down-regulation of ETB receptor expression or functional activity. The reasons for these species differences are not clear, but may relate to differences in the airway inflammatory response to parainfluenza-1 virus. 相似文献
53.
Henry Burek 《Ophthalmic & physiological optics》1990,10(3):280-285
The evaluation of the sphero-cylindrical components of curvature or refraction from measurements taken along three distinct meridians has been solved for various sets of three fixed meridians. A constraint of those solutions has been that the meridians of measurement are necessarily predetermined, which introduces an unwelcome restriction in experimental or clinical applications of tri-meridional analysis. A new solution is presented (in three formats: analogue computer, graphical and algebraic), which enables any set of three meridians to be used for tri-meridional analysis. A computer program listing (in BASIC) is included. 相似文献
54.
David H. Sutherland Kenton R. Kaufman Marilynn P. Wyatt Henry G. Chambers 《Gait & posture》1996,4(4):269-279
Botulinum A toxin (BOTOX®) was injected into the gastrocnemius muscle of 26 cerebral palsy subjects with equinus gait. All subjects were equinus walkers without fixed contracture of the triceps-surae muscle. Injections were performed at 3 month intervals, if needed, as determined by the treating clinician. There were 14 subjects with spastic hemiplegia, 11 subjects with spastic diplegia and 1 subject with spastic quadriplegia. In the case of those subjects with bilateral equinus gait the dose was divided and given into both the right and left gastrocnemius muscle. Gait analysis data was collected prior to the first injection and subsequently at 3 month intervals for 1 year. Kinematic and electromyographic data was obtained. This data was analyzed to provide objective information about the outcome of treatment. Four subjects moved away and were lost to follow-up. Seven subjects left the study to have surgery. The data collected revealed statistically significant improvements in dynamic ankle dorsiflexion in both stance and swing phases, stride length, and electromyography of the tibialis anterior. There were no complications. While the results of this study are promising, additional prospective studies are needed to determine the feasibility of preventing muscle contractures over a longer time period. Furthermore, there is a need for inclusion of other muscles in future research. Future research should also compare BOTOX® treatment with alternative methods of dealing with muscle spasticity such as: casting, orthotic devices, physical therapy, selective dorsal rhizotomy, and surgical lengthening. 相似文献
55.
This review summarises present knowledge of the chemistry, immunology, genetics and clinical significance of antibodies in the Lewis and secretor histoblood group systems. Although red cell serology has laid the foundations for these systems, more recent advances have been made by studying Lewis and related glycoconjugates with monoclonal antibodies, determining structures by mass spectrometry and NMR spectroscopy, identifying enzymes and their specificities, and identifying the genes by molecular biology. The expression of Lewis system antigens is dependent on Lewis and secretor loci. Fucosyltransferases coded by genes at these loci compete and interact with each other and with other transferases to determine an individual's Lewis and secretor phenotype. Exocrine epithelial cells, mostly of endodermal origin, synthesise the Lewis antigens which, as plasma glycolipids, are secondarily acquired by cells of the peripheral circulation. Phenotyping red cells is often regarded as a simple way of determining the Lewis and sometimes the secretor status of an individual; however, the red cell phenotype is influenced by many factors and may not necessarily reflect someone's Lewis and secretor genotypes. Two main red cell Lewis groups are usually found, Lewis negative and Lewis positive. In Lewis-negative individuals, the secretor genotype does not affect the Lewis phenotype, but in Lewis-positive individuals, the non-secretor genotype generates the Le(a+b–) phenotype, the secretor genotype causes the Le(a–b+) phenotype, and the partial secretor genotype gives rise to the Le(a+b+) phenotype. 相似文献
56.
57.
D. Douglas Miller Henry G. Stratmann Leslee Shaw Beaver R. Tamesis Mark D. Wittry Liwa T. Younis Bernard R. Chaitman 《Journal of nuclear cardiology》1994,1(1):72-82
Background
A total of 137 consecutive patients with recent uncomplicated myocardial infarction (n=31) or unstable angina (n=106) were studied to determine the relative prognostic value of predischarge clinical risk stratification and intravenous dipyridamole stress sestamibi (MIBI) myocardial tomography in patients unable to exercise maximally after an acute ischemic coronary event. 相似文献58.
59.
Christiane Eckhardt Jesse S Halvosa Susan M Ray Henry M Blumberg 《Infection control and hospital epidemiology》2003,24(6):460-461
Methicillin-resistant Staphylococcus aureus (MRSA) has traditionally been a nosocomial pathogen. However, several recent studies have noted community-acquired MRSA among young, healthy patients with no risk factors or healthcare system exposure. We report the transmission of a strain of community-acquired MRSA in our neonatal intensive care unit. 相似文献
60.
In the gerbil maintained at euthermic (37.5 degrees C) conditions, forward masking produces a compound action potential tuning curve (CAP TC) which is less sensitive but more sharply tuned than that which is generated by simultaneous masking. These differences between forward- and simultaneously-masked CAP TCs are minimized at hypothermic (30 degrees C) conditions. The unmasking effect occurs at both temperatures, suggesting that hypothermia does not exert these changes by eliminating two-tone suppression. 相似文献