柄果花椒酰胺的化学结构

前文报道从湖南地区采集的芸香科植物柄果花椒(Zanthoxylum podocarpum Hemsl.)树皮中分离并经鉴定的结晶有β-香树脂醇、β-谷甾醇、ι-芝麻素、ι-细辛素、新棒状花椒酰胺、新木脂体柄果脂素和山萮酸为主的混合脂肪酸等。并从该植物中分得另一结晶(Ⅸ),本文报道结晶(Ⅸ)的化学结构。     

Experimental research on production and uptake sites of TNFα in rats with acute hemorrhagic necrotic pancreatitis

ＥｘｐｅｒｉｍｅｎｔａｌｒｅｓｅａｒｃｈｏｎｐｒｏｄｕｃｔｉｏｎａｎｄｕｐｔａｋｅｓｉｔｅｓｏｆＴＮＦαｉｎｒａｔｓｗｉｔｈａｃｕｔｅｈｅｍｏｒｈａｇｉｃｎｅｃｒｏｔｉｃｐａｎｃｒｅａｔｉｔｉｓＱＩＮＲｅｎＹｉ，ＺＯＵＳｈｅｎｇＱｕａｎ，ＷＵＺ...     

天然有机化合物质谱研究——Ⅺ.苯丙型苷快原子轰击质谱MNa+的MIKES谱

研究了六种苯丙型苷与Na⁺加合离子的快原子轰击质谱(FAB—MS)和质量分离离子动能谱(MIKES)。结果表明:在FAB谱中[M+Na]⁺加合离子的丰度要比[M+H]⁺离子高得多。由此可给出糖苷的分子量信息,[M+Na]⁺离子的MIKES谱可给出糖基序列信息。     

用MUG-Indole法和药典法对大肠杆菌变异情况考察

目的：通过ＭＵＧ－Ｉｎｄｏｌｅ法和中国药典法对大肠杆菌变异情况考察,选出较优的大肠杆菌检验方法,方法：ＭＵＧ－Ｉｎｄｏｌｅ法和中国药典法配对试验,结果：两法无显著性差异。结论ＭＵＧ－Ｉｎｄｏｌｅ法优于中国药典法。     

Mésothéliome malin primitif du péritoine

Introduction

Peritoneal mesothelioma is a rare disease. Its diagnosis is difficult. It is based on immunohistochemical study. Its symptoms are non specific. Treatment suffers from the lack of standard therapy. Prognosis remains moderate especially with the trials cytoreductive surgery associated with intraperitoneal chemotherapy. We report the case of a patient followed at the medical oncology department of the university hospital Hassan II of Fez.

Patient and observation

A 54 years-old patient had a progressive increase in abdominal volume evolving in a context of deterioration of general condition, clinical and radiological examination found an ascitis with peritoneal thickening, and the diagnosis of primary malignant mesothelioma of the peritoneum was confirmed by immunohistochemical study.

Conclusion

Malignant peritoneal mesothelioma is a rare tumor, which suffer from the lack of a standard treatment hence the need of a multidisciplinary approach and the inclusion of patients in clinical trials.     

Lymphotropic herpesviruses in allogeneic bone marrow transplantation

Human herpesvirus-6 (HHV-6), human herpesvirus-7 (HHV-7), Epstein-Barr virus (EBV), and human cytomegalovirus (CMV) DNA were repeatedly assayed in peripheral blood leukocytes from 37 allogeneic bone marrow transplant (BMT) patients by polymerase chain reaction. Before BMT, HHV- 6 DNA was detected in 8 (22%) patients. HHV-7, EBV, and CMV DNA were detected in 21 (57%), 10 (27%), and 1 (3%) patient, respectively. After BMT, HHV-6 DNA was detected in 26 (70%), HHV-7 in 21 (57%), EBV in 28 (76%), and CMV in 21 (57%) patients. Thirty-two (87%) patients were positive with more than one virus. HHV-6, HHV-7, and EBV DNA were found earlier than CMV DNA in most patients after BMT. The proportions of HHV- 6-positive samples during the first 3 months after BMT were higher in the patients with either delayed granulocyte engraftment (P = .04, Fisher's exact test) or delayed platelet engraftment (P = .001, Fisher's exact test). The HHV-6 DNA in samples from the patients with delayed engraftment was confirmed to be variant B. The detection of any lymphotropic herpesvirus was not related to the development of acute graft-versus-host disease (aGVHD). High-dose acyclovir (ACV) prophylaxis significantly (P < .01) reduced the proportion of HHV-6- positive samples and tended to lower HHV-6 DNA levels (P = .06). Our data indicate that HHV-6 variant B can inhibit marrow engraftment and that high-dose ACV may be beneficial to engraftment after BMT by preventing HHV-6 reactivation. No relation between the proportions of HHV-7-, EBV-, and CMV-positive samples in the first 3 months and engraftment or aGVHD was found.     

Subacute myelopathy revealing systemic sarcoidosis

INTRODUCTION: The spinal localization is rare for neurosarcoidosis (0.43 percent of cases) but can be the inaugural manifestation of the disease. We report two cases of spinal neurosarcoidosis in a 57-year-old man and a 43-year*old woman with uneventful past medical histories. Both presented progressive myelopathic features. METHODS: Magnetic resonance imaging (MRI) of the spine demonstrated intramedullary lesions, dorsal in the first case, and cervical in the second case. Serum angiotensin converting enzyme was elevated. Radiographs of the chest revealed bilateral symmetric hilar mediastinal lymphadenopathy in the first patient, and bronchial biopsy demonstrated non caseating granulomas. In the second patient the diagnosis was made on pathological examination of a minor salivary gland biopsy. RESULTS: The patients received corticosteroid therapy with good response in the second patient. CONCLUSION: The diagnosis of intramedullary sarcoidosis is difficult without a previous diagnosis of systemic sarcoidosis or other apparent symptom(s). Extraneurologic biopsies may be suggestive. We reviewed the literature on the diagnosis and treatment of intramedullary sarcoidosis.