口腔医生工效学负荷和工作相关肌肉骨骼疾患的研究

目的 评估口腔医生工效学负荷水平，探讨其与工作相关肌肉骨骼疾患（WMSDs）的相关性。方法 采用《中国肌肉骨骼疾患问卷》调查口腔医生WMSDs的患病情况，采用快速上肢评估（RULA）法进行现场工效学评估，并分析其相关性。结果 口腔医生WMSDs患病率为56.1%，各部位患病率差异有统计学意义（X2=62.400，P<0.01），颈部最高；女性患病率高于男性（X2=16.020，P<0.01）。RULA法评估口腔医生工效学负荷平均得分为5.6±1.1，82.4%的口腔医生工效学负荷等级Ⅲ～Ⅳ级。多因素Logistic回归分析显示，工效学负荷Ⅲ级和Ⅳ级（OR=2.413、14.700）、女性（OR=3.670）、中级职称（OR=2.479）、身高<160 cm或≥175 cm（OR=3.708）均为WMSDs的危险因素。WMSDs患病率与工效学负荷之间存在相关性（P<0.05），患病率随工效学负荷的增加而递增。结论 工效学负荷是WMSDs的危险因素；口腔医生WMSDs患病率高，工效学负荷水平高，需予以关注并尽快加以改善。     

重睑成形术前术后外眼形态的变化

目的：揭示重睑成形术后外眼形态变化的规律。方法：对９２例１８４只眼睛重睑成形术者术前术后眼裂高度和长度,两眼间距,眼球最突点位置,睫毛显露长度和上翘角度测量结果对比分析。结果：重睑成形术后眼裂高度,睫毛显露长度及睫毛上翘角度有显著性增大。结论：重睑成形术能使眼裂变大,睫毛全长暴露及睫毛上翘,从而增加眼睛的美感。     

河南“4.26”60Co源辐射事故3例中重度骨髓型急性放射病临床报告

目的：通过对^60Co源事故3种例中重度骨髓型急性放射病（ARS）患者的剂量估算,临床经过和诊治方法的总结,以积累临床资料,方法：依据受照剂量,临床表现,实验实检测结果进行综合分析,以明确诊断,治疗上经全环境保护隔离,在有指征对症治疗的基础上,应用了造血生长因子,结果：3例病人经过83d住治疗,达到临床治愈,结论：正确的早期分类诊断和初期的积极治疗有利于安全度过极期,女病人如正逢病程极期来月预雄性激素以改变经期,可避免大出血,适时足量应用粒－巨噬细胞集落刺激因子（GM－CSF）有助造血功能恢复。     

子宫动脉超声多普勒血流监测在妊娠期高血压疾病晚期中的应用

目的 探讨子宫动脉超声多普勒血流监测在妊娠期高血压疾病晚期中的应用价值.方法 超声检测68例妊娠期高血压疾病和47例正常妊娠孕妇(对照组)的子宫动脉血流动力学参数:收缩-舒张流速比(S/D)、阻力指数、搏动指数,比较两组子宫动脉各血流参数及妊娠结局的差异;同时将妊娠期高血压疾病阻力指数正常组与异常组的妊娠结局进行比较....     

中医针灸标准化关键问题研究

针对中医标准化理论方法不足、共性技术缺乏、评价体系缺失等关键性问题,开展了中医标准化理论与方法学的研究,在理论方面,提出了中医标准化发展战略,明确了国际中医针灸标准发展现状,构建了以标准研制为主体的针灸标准体系,提出中医标准化基本理论,厘清了标准化研究中几个重要的关系问题;在方法技术方面,提出了"三证合一"的指南制定方法并得到应用,提出了中医证据分级标准及证据集合方案,构建了标准适用性评价方法,总结了标准化人才培养方法;在中医药院校开设《中医药标准化导论》课程,提高了标准研制质量,推动了中医标准化发展,对中医标准研制起到了引领和示范作用。     

临床药学领域专业学位研究生培养模式探索

本研究采用文献调研结合实践总结等方法,分析临床药学领域开展专业学位研究生培养的必要性。对现阶段专业课程设置、导师队伍、实践教学等方面存在的问题进行探讨;提出医科院校应发挥临床资源优势和特色,借鉴临床药师培训基地人才培养经验,优化课程体系,遴选导师队伍,重视实践教学等建议;以提高临床药学领域专业学位研究生教育质量,培养高水平临床药师,推动我国临床药学事业发展。     

Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts

Mice deficient in Schnurri-3 (SHN3; also known as HIVEP3) display increased bone formation, but harnessing this observation for therapeutic benefit requires an improved understanding of how SHN3 functions in osteoblasts. Here we identified SHN3 as a dampener of ERK activity that functions in part downstream of WNT signaling in osteoblasts. A D-domain motif within SHN3 mediated the interaction with and inhibition of ERK activity and osteoblast differentiation, and knockin of a mutation in Shn3 that abolishes this interaction resulted in aberrant ERK activation and consequent osteoblast hyperactivity in vivo. Additionally, in vivo genetic interaction studies demonstrated that crossing to Lrp5^–/– mice partially rescued the osteosclerotic phenotype of Shn3^–/– mice; mechanistically, this corresponded to the ability of SHN3 to inhibit ERK-mediated suppression of GSK3β. Inducible knockdown of Shn3 in adult mice resulted in a high–bone mass phenotype, providing evidence that transient blockade of these pathways in adults holds promise as a therapy for osteoporosis.     

北川县地震后院前急救疾病谱的流行病学研究

目的探讨北川县地震后院前急救患者的流行病学特点。方法对2010年10月1日至2012年10月31日北川县人民医院院前急救接诊的患者性别、年龄、出诊时间、诊断等项目进行调查。结果三年中,院前急救系统救治患者人数稳定增长,总计1281例,男女比例分别为62.71%和37.29%,年龄(41.79±18.41)岁。院前急救前4大类疾病依次是心脑血管疾病(26.13%)、创伤(16.72%)、急性中毒(10.69%)、急腹症(5.92%)。急救呼叫服务时间主要分布在9～21时。院前救治成功率平均为95.65%,并呈逐年递增趋势。结论新北川县医院具备了良好的院前急救能力,可为建立县级急诊医疗服务体系和提高院前急救质量与管理水平提供科学依据。     

Common cancer-related symptoms among GP patients Opportunistic screening in primary health care

Objective - To study the occurrence of symptoms related to the five most common forms of cancer among patients regularly visiting primary care. To estimate the proportion of symptoms needing GP examination, and the number of tumours thus diagnosed. Design - Patients with some form of non-malignant chronic disease received a letter with information about cancer-related symptoms along with an invitation to regular check-up. The letter described the most common symptoms of breast, colorectal, lung, prostate and skin cancers. Setting - 12 health centres in Kalmar County, Sweden. Subjects - 5200 patients aged over 40 years. Results - One patient in 13 reported cancer-related symptoms to the GP. Women reported more symptoms than men, and almost half of them had had symptoms at previous check-ups. The GP was able to explain 7 out of 10 patients' symptoms directly. When other symptoms were examined, 8 cancers were diagnosed as well as 6 pre-malignant tumours, corresponding to 3 tumour diagnoses per 1000 check-ups. Conclusion ? While attending regular check-ups, patients may not report symptoms which cause anxiety and sometimes indicate serious diseases. It is possible to widen the perspective and link both primary and secondary prevention of certain cancers to the check-up.