全文获取类型
收费全文 | 735篇 |
免费 | 38篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 12篇 |
妇产科学 | 90篇 |
基础医学 | 100篇 |
口腔科学 | 4篇 |
临床医学 | 55篇 |
内科学 | 115篇 |
皮肤病学 | 13篇 |
神经病学 | 72篇 |
特种医学 | 90篇 |
外科学 | 54篇 |
综合类 | 11篇 |
预防医学 | 25篇 |
眼科学 | 13篇 |
药学 | 53篇 |
中国医学 | 1篇 |
肿瘤学 | 75篇 |
出版年
2023年 | 6篇 |
2022年 | 7篇 |
2021年 | 13篇 |
2020年 | 6篇 |
2019年 | 8篇 |
2018年 | 13篇 |
2017年 | 8篇 |
2016年 | 11篇 |
2015年 | 15篇 |
2014年 | 10篇 |
2013年 | 20篇 |
2012年 | 14篇 |
2011年 | 17篇 |
2010年 | 14篇 |
2009年 | 15篇 |
2008年 | 21篇 |
2007年 | 27篇 |
2006年 | 17篇 |
2005年 | 19篇 |
2004年 | 26篇 |
2003年 | 28篇 |
2002年 | 23篇 |
2001年 | 22篇 |
2000年 | 25篇 |
1999年 | 14篇 |
1998年 | 17篇 |
1997年 | 13篇 |
1996年 | 9篇 |
1995年 | 16篇 |
1994年 | 15篇 |
1993年 | 10篇 |
1992年 | 24篇 |
1991年 | 19篇 |
1990年 | 26篇 |
1989年 | 30篇 |
1988年 | 20篇 |
1987年 | 30篇 |
1986年 | 35篇 |
1985年 | 19篇 |
1984年 | 17篇 |
1983年 | 19篇 |
1982年 | 7篇 |
1981年 | 4篇 |
1980年 | 8篇 |
1979年 | 9篇 |
1978年 | 6篇 |
1977年 | 5篇 |
1976年 | 7篇 |
1975年 | 6篇 |
1973年 | 7篇 |
排序方式: 共有794条查询结果,搜索用时 15 毫秒
791.
Suad AL-ALousi John A. Carlson Karen Blessing Martin Cook Themis Karaoli Raymond L. Bamhill 《Journal of cutaneous pathology》1996,23(2):118-125
Basic fibroblast growth factor (bFGF) is an established growth factor for melanocytes and a potent angiogenic factor. The expression of bFGF was investigated in 23 desmoplastic melanomas. (DM) (12 males, median age 64 years, and 11 females, median age 54 years) by immunostaining of formalin-fixed, paraffin-embedded sections with high-affinity purified antibody raised against recombinant human bFGF (Scios Nova, Inc.). The tumors were characterized by level II invasion in 1 case (5%), level IV invasion in 11 cases (48%), level V invasion in 8 cases (35%), and indeterminate in 3 cases. bFGF expression was observed in 22 of 23 tumors (95%), either immune localized to tumor cell nuclei in 17 of 22 tumors (77%), or to the cytoplasm of tumor cells in 5 of 22 tumors (23%). Also in these cases, bFGF was strongly expressed in the nuclei of vascular endothelial cells. Maximal expression was noted in the peripheral blood vessels of 20 tumors (91%) versus intratumoral vessels of 13 DM (59%). In conclusion, the expression of predominantly nuclear bFGF by tumor cells in DM suggests a role in mediating the desmoplastic phenotype. In addition, the localization of bFGF to vascular cndothelium, particularly at the periphery of the tumor, may be relevant to tumor angiogenesis. 相似文献
792.
793.
Matthew Hodapp Anne V. Hing Emily Gallagher Matthew Blessing Michael L. Cunningham 《American journal of medical genetics. Part A》2023,191(10):2651-2655
Isolated frontosphenoidal craniosynostosis (IFSC) is a rare congenital defect defined as premature fusion of the frontosphenoidal suture in the absence of other suture fusion. Until now, IFSC was regarded as a phenomenon with an unclear genetic etiology. We have identified three cases with IFSC with underlying syndromic diagnoses that were attributable to pathogenic mutations involving FGFR3 and MN1, as well as 22q11.2 deletion syndrome. These findings suggest a genetic predisposition to IFSC may exist, thereby justifying the recommendation for genetic evaluation and testing in this population. Furthermore, due to improved imaging resolution, cases of IFSC are now readily identified. With the identification of IFSC with underlying genetic diagnoses, in combination with significant improvements in imaging resolution, we recommend genetic evaluation in children with IFSC. 相似文献