全文获取类型
收费全文 | 3194篇 |
免费 | 278篇 |
国内免费 | 201篇 |
专业分类
耳鼻咽喉 | 51篇 |
儿科学 | 44篇 |
妇产科学 | 25篇 |
基础医学 | 416篇 |
口腔科学 | 53篇 |
临床医学 | 390篇 |
内科学 | 490篇 |
皮肤病学 | 58篇 |
神经病学 | 261篇 |
特种医学 | 90篇 |
外国民族医学 | 1篇 |
外科学 | 327篇 |
综合类 | 442篇 |
现状与发展 | 1篇 |
一般理论 | 2篇 |
预防医学 | 213篇 |
眼科学 | 70篇 |
药学 | 304篇 |
6篇 | |
中国医学 | 111篇 |
肿瘤学 | 318篇 |
出版年
2024年 | 12篇 |
2023年 | 45篇 |
2022年 | 105篇 |
2021年 | 125篇 |
2020年 | 95篇 |
2019年 | 98篇 |
2018年 | 122篇 |
2017年 | 78篇 |
2016年 | 87篇 |
2015年 | 147篇 |
2014年 | 143篇 |
2013年 | 144篇 |
2012年 | 184篇 |
2011年 | 248篇 |
2010年 | 156篇 |
2009年 | 121篇 |
2008年 | 142篇 |
2007年 | 173篇 |
2006年 | 174篇 |
2005年 | 177篇 |
2004年 | 136篇 |
2003年 | 125篇 |
2002年 | 111篇 |
2001年 | 84篇 |
2000年 | 77篇 |
1999年 | 102篇 |
1998年 | 48篇 |
1997年 | 44篇 |
1996年 | 38篇 |
1995年 | 24篇 |
1994年 | 22篇 |
1993年 | 20篇 |
1992年 | 36篇 |
1991年 | 35篇 |
1990年 | 31篇 |
1989年 | 17篇 |
1988年 | 18篇 |
1987年 | 16篇 |
1986年 | 11篇 |
1985年 | 6篇 |
1984年 | 11篇 |
1983年 | 11篇 |
1982年 | 6篇 |
1981年 | 5篇 |
1979年 | 7篇 |
1978年 | 6篇 |
1975年 | 5篇 |
1973年 | 9篇 |
1968年 | 4篇 |
1966年 | 4篇 |
排序方式: 共有3673条查询结果,搜索用时 15 毫秒
61.
62.
63.
X Pi CE Schmitt L Xie AL Portbury Y Wu P Lockyer LA Dyer M Moser G Bu EJ Flynn SW Jin C Patterson 《Circulation research》2012,111(5):564-574
Rationale: Among the extracellular modulators of Bmp (bone morphogenetic protein) signaling, Bmper (Bmp endothelial cell precursor-derived regulator) both enhances and inhibits Bmp signaling. Recently we found that Bmper modulates Bmp4 activity via a concentration-dependent, endocytic trap-and-sink mechanism. Objective: To investigate the molecular mechanisms required for endocytosis of the Bmper/Bmp4 and signaling complex and determine the mechanism of Bmper's differential effects on Bmp4 signaling. Methods and Results: Using an array of biochemical and cell biology techniques, we report that LRP1 (LDL receptor-related protein 1), a member of the LDL receptor family, acts as an endocytic receptor for Bmper and a coreceptor of Bmp4 to mediate the endocytosis of the Bmper/Bmp4 signaling complex. Furthermore, we demonstrate that LRP1-dependent Bmper/Bmp4 endocytosis is essential for Bmp4 signaling, as evidenced by the phenotype of lrp1-deficient zebrafish, which have abnormal cardiovascular development and decreased Smad1/5/8 activity in key vasculogenic structures. Conclusions: Together, these data reveal a novel role for LRP1 in the regulation of Bmp4 signaling by regulating receptor complex endocytosis. In addition, these data introduce LRP1 as a critical regulator of vascular development. These observations demonstrate Bmper's ability to fine-tune Bmp4 signaling at the single-cell level, unlike the spatial regulatory mechanisms applied by other Bmp modulators. 相似文献
64.
65.
66.
67.
Ru Li Zhi-li Li Ya-ping Chen Wei-quan Bu Wen-bo Ding Bing Yang Chun-fei Wang Liang Ma Xiao-bin Jia Liang Feng 《RSC advances》2020,10(65):39385
The purpose of this study is to explore the intrinsic reasons for the superiority of the salt-made geoherb Alisma orientale via comparing the content of various components of the salt-made geoherb Alisma orientale. The effects of “diuresis and diffusing dampness” using salt-made Alisma orientale from seven different origins were investigated through pharmacodynamic experiments in vivo and in vitro. The results indicated that salt-made Alisma orientale from different origins had diuretic efficacy; this was demonstrated by the significant increase in the volume of rat urine, the concentration of Na+, K+, and Cl− in the urine, and the significant decrease in the levels of AQP-2 in rat renal medulla and HK-2 cells. It was also revealed that the diuretic effect of salt-made Alisma orientale from Fujian Province is stronger than those from other provinces. Moreover, the main components and their proportions in the salt-made Alisma orientale samples were further analyzed via principal component analysis. The results showed that alisol A 24-acetate, alisol B, and 23-acetyl alisol B are the main components of salt-made Alisma orientale, and the optimal structural ratio of alisol A 24-acetate, alisol B, and 23-acetyl alisol B was found to be 5.38 : 14.34 : 11.31 via optimizing the ratios of the three main components. It is worth noting that the optimal ratio of the three main components after optimization is the closest to the ratio of the three main components in salt-made Alisma orientale from Fujian Province. This paper reveals the “mystery” of the content ratio of the main active components and its effect on the efficacy, and showed that the proportional relationship between the content of multiple components is the key to their interactions. Therefore, this method of evaluating the quality of salt-made Alisma orientale is obviously reliable, and this study lays the foundations for quality evaluation of salt-made Alisma orientale and other herb slices.The purpose of this study is to explore the intrinsic reasons for the superiority of the salt-made geoherb Alisma orientale via comparing the content of various components of the salt-made geoherb Alisma orientale. 相似文献
68.
69.
Lasers in Medical Science - To describe the clinical features of refractory hidradenitis suppurativa (HS) patients (Hurley stageII and stage III) and evaluate the efficacy of combined treatment of... 相似文献
70.
Li Nannan Xu Bei Zeng Jiangping Lei Shihui Gu Lei Feng Lijin Zhu Bing Huang Yueye Wang Lu Su Lili Qu Shen Cheng Xiaoyun Bu Le 《Obesity surgery》2022,32(4):1184-1192
Obesity Surgery - Bariatric surgery is the most effective therapy for obesity, but targeted weight reduction is not always achieved. Serum lipocalin-2 (LCN2) is closely associated with obesity, but... 相似文献