全文获取类型
收费全文 | 2441篇 |
免费 | 92篇 |
国内免费 | 35篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 31篇 |
妇产科学 | 43篇 |
基础医学 | 298篇 |
口腔科学 | 25篇 |
临床医学 | 224篇 |
内科学 | 525篇 |
皮肤病学 | 26篇 |
神经病学 | 137篇 |
特种医学 | 283篇 |
外科学 | 196篇 |
综合类 | 33篇 |
一般理论 | 1篇 |
预防医学 | 244篇 |
眼科学 | 77篇 |
药学 | 198篇 |
中国医学 | 1篇 |
肿瘤学 | 224篇 |
出版年
2021年 | 11篇 |
2019年 | 15篇 |
2018年 | 25篇 |
2017年 | 24篇 |
2016年 | 29篇 |
2015年 | 42篇 |
2014年 | 56篇 |
2013年 | 64篇 |
2012年 | 93篇 |
2011年 | 91篇 |
2010年 | 84篇 |
2009年 | 76篇 |
2008年 | 94篇 |
2007年 | 135篇 |
2006年 | 118篇 |
2005年 | 118篇 |
2004年 | 87篇 |
2003年 | 96篇 |
2002年 | 83篇 |
2001年 | 102篇 |
2000年 | 82篇 |
1999年 | 82篇 |
1998年 | 58篇 |
1997年 | 61篇 |
1996年 | 48篇 |
1995年 | 32篇 |
1994年 | 27篇 |
1993年 | 29篇 |
1992年 | 38篇 |
1991年 | 49篇 |
1990年 | 46篇 |
1989年 | 55篇 |
1988年 | 51篇 |
1987年 | 34篇 |
1986年 | 32篇 |
1985年 | 31篇 |
1984年 | 19篇 |
1983年 | 18篇 |
1981年 | 22篇 |
1979年 | 21篇 |
1978年 | 18篇 |
1975年 | 14篇 |
1974年 | 12篇 |
1973年 | 11篇 |
1972年 | 14篇 |
1971年 | 12篇 |
1933年 | 12篇 |
1932年 | 14篇 |
1931年 | 21篇 |
1926年 | 11篇 |
排序方式: 共有2568条查询结果,搜索用时 15 毫秒
11.
12.
The parkinsonism that occurs in some patients with olivopontocerebellar atrophy (OPCA) can cause diagnostic confusion with idiopathic Parkinson's disease (IPD). The response to levodopa is usually a distinguishing feature, the OPCAs either failing to benefit or losing efficacy relatively quickly. A fluctuating response to levodopa in those OPCA patients who do benefit has not been emphasized in the literature previously. Reported here are three patients with presumed OPCA, dominated by parkinsonian features, who eventually developed typical fluctuations with morning akinesia, wearing off, and periodic lack of response related to meals. These fluctuations were a major source of disability and an important reason for diagnostic confusion with IPD. The possible mechanisms of these fluctuations are discussed. 相似文献
13.
Distribution and excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin in congenic strains of mice which differ at the Ah locus 总被引:2,自引:0,他引:2
L S Birnbaum 《Drug metabolism and disposition》1986,14(1):34-40
The effect of the genetic background on the distribution and excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was examined in two sets of congenic mouse strains in which the congenic pairs differed only at the Ah locus. Male C57BL/6J mice which were either Ahb/Ahd or Ahd/Ahd and female DBA/2J mice which were also Ahb/Ahd or Ahd/Ahd were treated with 500 ng/kg 3H-TCDD and held from 1 to 42 days in individual metabolism cages. Daily excretion and tissue distribution at eight time points were determined. The Ah locus had no effect on the distribution of TCDD-derived radioactivity to the major tissue depots of adipose tissue, skin, kidney, carcass, and blood but seemed to cause elevated levels in the liver. The Ah locus also played no role in either the rate or the extent of urinary and/or fecal excretion. However, the route and rates of excretion did vary between the congenic sets with the male C57BL/6J mice excreting greater amounts of radioactivity in the urine and less in the feces than the female DBA/2J mice. The Ah locus also had no effect on the liver weight or adipose tissue volume in either congenic set. Thus, at the dose level studied, the distribution and excretion of TCDD were primarily governed by the total genetic background rather than the allele present at the Ah locus. 相似文献
14.
15.
A. Dornelas de Andrade J. Birnbaum A. Lanteaume J. L. Izard P. Corget M. F. Artillan M. Toumi D. Vervloet D. Charpin 《Allergy》1995,50(2):142-146
Because the mite-allergen content in homes is highly variable even in the same geographic area, we tried to determine which variables influence mite infestation. We evaluated mite-allergen content in bedding relative to housing conditions and living habits. This cross-sectional study included 108 homes. Housing conditions were assessed by an architect and living habits by a researcher specialized in social and family economics. Group I allergen level was measured on the mattress dust with monoclonal antibodies, and relative humidity (RH) was monitored in the bedroom during a 2-week period. Homes with low RH did have low mite-allergen content. In contrast, homes with intermediate RH levels had very variable mite-allergen content. Using analysis of variance and a logistic regression analysis, we were unable to identify any variable predictive of mite-allergen content. Thus, factors other than relative humidity seem to influence mite infestation. Moreover, the absence of association between mite infestation and ventilation rate might be accounted for by the gentle climate in our area with notable outdoor RH. 相似文献
16.
Viviane D Lima Patricia Kretz Anita Palepu Simon Bonner Thomas Kerr David Moore Mark Daniel Julio SG Montaner Robert S Hogg 《AIDS research and therapy》2006,3(1):14-9
Background
Although the impact of Aboriginal status on HIV incidence, HIV disease progression, and access to treatment has been investigated previously, little is known about the relationship between Aboriginal ethnicity and outcomes associated with highly active antiretroviral therapy (HAART). We undertook the present analysis to determine if Aboriginal and non-Aboriginal persons respond differently to HAART by measuring HIV plasma viral load response, CD4 cell response and time to all-cause mortality. 相似文献17.
Reciprocal translocations in breast tumor cell lines: cloning of a t(3;20) that targets the FHIT gene 总被引:1,自引:0,他引:1
18.
Vyshkina T Shugart YY Birnbaum G Leist TP Kalman B 《European journal of human genetics : EJHG》2005,13(2):240-247
Linkage studies in multiple sclerosis (MS) identified several susceptibility loci. One of these regions includes chromosome 17q11 where a meta-analysis of data from three genome scans suggested linkage. This region encodes a cluster of genes for beta-chemokines or CC chemokine ligands (CCLs), which may be involved in the development of MS lesions. Here we aimed to test if CCL alleles and haplotypes are associated with MS. Using methods of linkage and association, we observed deviations from the expected 50% transmission of haplotypes from unaffected parents to their affected children at CCL2, CCL11-CCL8-CCL13 and CCL3 within the investigated 1.85 MB chromosomal segment. Analyses of the linkage disequilibrium map support that variants with possible relevance to MS can be located within these subregions. Identification of MS associated CCL variants may have direct clinical significance, as it can lead to the design of small competitive antagonists of these molecules with beneficial effects in the treatment of patients with early and active disease. 相似文献
19.
20.
C T Anderson J O Westgard K Schlimgen M L Birnbaum 《American journal of clinical pathology》1977,68(1):63-67
Arterial blood samples from 202 critically ill patients were studied. Lactate concentration, PO2, PCO2, pH, oxygen saturation, total CO2, and toe temperature were measured. Base excess, buffer base, actual bicarbonate, and standard bicarbonate were calculated. Analysis of the initial data obtained from each patient revealed that lactate concentration alone could not be used to predict survival. Elevations in lactate concentrations were observed in all types of acid-base disturbances. Survival was lowest (30%) for patients in metabolic acidosis with respiratory compensation, mean lactate concentration 10.5 mEq/l (mmol/l), and highest (65%) for patients in uncompensated respiratory alkalosis, mean lactate concentration, 2.57 mEq/l (mmol/l). Knowing the type of acid-base disturbance is necessary to evaluate the significance of elevated blood lactate values. 相似文献