Changes in oculocentric visual direction induced by the recalibration of saccades

The association between perceived visual direction and retinal location has been considered to be specified at birth and unmodifiable. We found that small changes occurred in the visual direction associated with a peripheral retinal location when the amplitudes of saccadic eye movements to a target imaged at that location were experimentally increased or decreased. This result indicates that at least limited plasticity exists in the perceptual representation of retinal location.     

Choices about cardiopulmonary resuscitation in the hospital. When do physicians talk with patients?

We studied the extent to which 82 private physicians and 75 house officers talked with hospitalized patients or their families (or both) about whether they would desire cardiopulmonary resuscitation if it became necessary. During the period of study (1981), 154 patients were resuscitated at our university teaching hospital. In 68 per cent of the cases, physicians had formed an opinion about the patient's attitude toward cardiopulmonary resuscitation. However, only 30 (19 per cent) of the patients had discussed resuscitation before the arrest with either their private physician or a house officer (or both); 51 (33 per cent) of the families were consulted. These percentages did not differ significantly according to the underlying disease, whether the patient was on the general wards or in the intensive-care unit, the physician's estimate of the probability of arrest, or the physician's level of training. Even the 151 physicians who believed that patients should participate in decisions about resuscitation, actually discussed the issue with their patients only rarely. We interviewed the 24 competent patients who survived cardiopulmonary resuscitation, to compare their actual attitudes about resuscitation with their physicians' opinions about their attitudes. The physician's opinion about a patient's desire for resuscitation correlated only weakly with the preference expressed by the patient. We suggest that physicians and patients consider the benefit of open discussion about cardiopulmonary resuscitation.     

Defining the information content of health data systems

Uses of health information systems depend heavily on the background and experiences of those who evaluate the data. Effective collaboration between physicians and system managers can enhance significantly the decision-making and information obtained from these systems. This article describes some methods of collaboration and the current uses of one system developed through collaborative efforts of physicians and system managers.     

Analgesic nephropathy

Many questions about analgesic nephropathy (AN) lack clear-cut answers. We present available evidence for and against proposed answers to many of these questions. These include: (1) Is acetaminophen (AC) nephrotoxic when taken as the sole analgesic? (2) Is the combination of acetylsalicylic acid (ASA) and AC more nephrotoxic than AC taken alone, and if so, why? (3) What are the minimum doses and durations of ingestion required to produce analgesic nephrotoxicity? (4) Is the combination of ASA and AC (a major metabolite of phenacetin) less nephrotoxic than that of phenacetin and ASA combined? (5) Does caffeine in combination with analgesics contribute to nephrotoxicity? (6) What is the incidence of end-stage renal disease (ESRD) due to AN? (7) What uniform diagnostic criteria should be established for AN? (8) What are the earliest anatomic and biochemical abnormalities? (9) What are the mechanisms of renal injury? (10) Does AC cause uroepithelial neoplasia? (11) What research might be most beneficial? Based mainly on associations, some strong, we suggest that AN still exists as a cause of ESRD in the United States, where AC/ASA combinations are available over the counter, and in Canada, where they are not. We also suggest that the evidence needed to recommend that the AC/ASA combination be excluded from over-the-counter analgesic preparations still has limitations. A prospective multicenter study comparing incidence related to AC/ASA in the United States and to AC in Canada and the United States may be needed to answer this question. For such a study to be worthwhile, an adequate incidence in both countries is required.     

Radiologic diagnosis of oat cell cancer in a high-risk screened population

A screening program of 10,040 cigarette-smoking men over 45 years of age was undertaken in an attempt to achieve earlier diagnosis, thereby increasing the cure rate, of oat cell lung cancer. Of the 155 men who were found to have lung cancer, 27 (17%) had confirmed oat cell cancer. Only one case was diagnosed at the first examination. The other 26 cases (called incidence cancer) were diagnosed by subsequent examinations. In 24 of the 26 patients, the tumor was not found until it was advanced (Stage III), and of these patients, only one is alive at 21 months follow-up. Two tumors were diagnosed as oat cell carcinoma at an early stage (Stage I), and both patients are alive with no evidence of disease at seven and 24 months. The screening program used in this study did not succeed in detecting oat cell cancer at an early stage.     

花生四烯酸、二十碳五烯酸及二十二碳六烯酸对兔主动脉条张力的影响

外源性AA引起兔动脉条收缩,呈剂量依赖性;EPA抑制AA收缩血管亦呈浓度依赖性;DHA对AA收缩血管作用无明显影响。破坏血管内皮后AA收缩血管作用大为减弱,EPA抑制AA收缩血管作用也几乎消失。吲哚美辛能阻断AA收缩兔主动脉条的作用。兔主动脉6-keto-PGF_1α、TXB₂及其比值随AA浓度升高而增加,低剂量EPA对前列腺素类代谢无明显影响,较大剂量时则降低上述指标。