全文获取类型
收费全文 | 773篇 |
免费 | 64篇 |
国内免费 | 10篇 |
专业分类
儿科学 | 34篇 |
妇产科学 | 7篇 |
基础医学 | 75篇 |
口腔科学 | 29篇 |
临床医学 | 79篇 |
内科学 | 195篇 |
皮肤病学 | 22篇 |
神经病学 | 72篇 |
特种医学 | 112篇 |
外科学 | 85篇 |
综合类 | 32篇 |
预防医学 | 29篇 |
眼科学 | 12篇 |
药学 | 41篇 |
肿瘤学 | 23篇 |
出版年
2022年 | 3篇 |
2021年 | 7篇 |
2020年 | 11篇 |
2019年 | 22篇 |
2018年 | 27篇 |
2017年 | 14篇 |
2016年 | 4篇 |
2015年 | 23篇 |
2014年 | 18篇 |
2013年 | 24篇 |
2012年 | 27篇 |
2011年 | 30篇 |
2010年 | 28篇 |
2009年 | 35篇 |
2008年 | 21篇 |
2007年 | 26篇 |
2006年 | 29篇 |
2005年 | 18篇 |
2004年 | 33篇 |
2003年 | 19篇 |
2002年 | 15篇 |
2001年 | 11篇 |
2000年 | 12篇 |
1999年 | 13篇 |
1998年 | 27篇 |
1997年 | 25篇 |
1996年 | 39篇 |
1995年 | 20篇 |
1994年 | 16篇 |
1993年 | 22篇 |
1992年 | 11篇 |
1991年 | 13篇 |
1990年 | 17篇 |
1989年 | 13篇 |
1988年 | 19篇 |
1987年 | 18篇 |
1986年 | 19篇 |
1985年 | 16篇 |
1984年 | 10篇 |
1983年 | 13篇 |
1982年 | 9篇 |
1981年 | 15篇 |
1980年 | 8篇 |
1978年 | 6篇 |
1977年 | 7篇 |
1976年 | 8篇 |
1975年 | 4篇 |
1973年 | 5篇 |
1972年 | 5篇 |
1970年 | 3篇 |
排序方式: 共有847条查询结果,搜索用时 11 毫秒
71.
72.
L Guyot E Naline J Moreau J P Gnassounou O Varoquaux G Barbe B Estenne M Pays C Advenier 《Thérapie》1989,44(4):285-289
Ceftriaxone is a third generation cephalosporin remarkable for its wide distribution in the biliary tract. The purpose of this study was to determine whether biliary tract pathology, as observed during surgery, had an influence on this distribution. 52 patients about to be operated upon and presenting with a high risk of bile infection received a single 1 or 2 g dose of ceftriaxone administered intravenously over 20 min during the hour that preceded surgery. Samples of blood and of bile from the gallbladder (GB) and the common bile duct (CBD), as well as specimens of the GB wall were taken during the operation. In patients whose GB was normal at laparotomy (apart from stones) ceftriaxone concentrations in bile and GB wall were 10-25 and 2 times respectively higher than in plasma. In patients with a grossly distended but not infected GB (hydrocholecystis) ceftriaxone levels were high in CBD bile but null in GB bile and only one-quarter to one-half of plasma levels in GB wall. In patients with stones in the CBD or inflamed GB wall ceftriaxone levels were high in bile (although lower than in cases with normal GB) and similar to plasma levels in GB wall. When malignant pancreatic lesions were present ceftriaxone concentrations could not be measured in both GB and CBD bile but reached 50% of plasma concentrations in GB wall.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
73.
David?M.?Klyne Mary?F.?Barbe Wolbert?van den?Hoorn Paul?W.?HodgesEmail author 《European spine journal》2018,27(4):763-777
Study design
Prospective longitudinal study.Objective
To determine whether systemic cytokines and C-reactive protein (CRP) during an acute episode of low back pain (LBP) differ between individuals who did and did not recover by 6 months and to identify sub-groups based on patterns of inflammatory, psychological, and sleep features associated with recovery/non-recovery.Summary of background data
Systemic inflammation is observed in chronic LBP and may contribute to the transition from acute to persistent LBP. Longitudinal studies are required to determine whether changes present early or develop over time. Psychological and/or sleep-related factors may be related.Methods
Individuals within 2 weeks of onset of acute LBP (N = 109) and pain-free controls (N = 55) provided blood for assessment of CRP, tumor necrosis factor (TNF), interleukin-6 (IL-6) and interleukin-1β, and completed questionnaires related to pain, disability, sleep, and psychological status. LBP participants repeated measurements at 6 months. Biomarkers were compared between LBP and control participants at baseline, and in longitudinal (baseline/6 months) analysis, between unrecovered (≥pain and disability), partially recovered (reduced pain and/or disability) and recovered (no pain and disability) participants at 6 months. We assessed baseline patterns of inflammatory, psychological, sleep, and pain data using hierarchical clustering and related the clusters to recovery (% change in pain) at 6 months.Results
CRP was higher in acute LBP than controls at baseline. In LBP, baseline CRP was higher in the recovered than non-recovered groups. Conversely, TNF was higher at both time-points in the non-recovered than recovered groups. Two sub-groups were identified that associated with more (“inflammatory/poor sleep”) or less (“high TNF/depression”) recovery.Conclusions
This is the first evidence of a relationship between an “acute-phase” systemic inflammatory response and recovery at 6 months. High inflammation (CRP/IL-6) was associated with good recovery, but specific elevation of TNF, along with depressive symptoms, was associated with bad recovery. Depression and TNF may have a two-way relationship.Graphical abstract
These slides can be retrieved under Electronic Supplementary Material.
74.
75.
Jeffrey B. Driban Michael R. Sitler Mary F. Barbe Easwaran Balasubramanian 《Clinical rheumatology》2010,29(2):123-131
Osteoarthritis is a heterogeneous disease characterized by variable clinical features, biochemical/genetic characteristics,
and responses to treatments. To optimize palliative effects of current treatments and develop efficacious disease-modifying
interventions, treatments may need to be tailored to the individual or a subset of osteoarthritic joints. The purpose of this
review is to explore the current literature on the clinical and physiological variability in osteoarthritis and potential
for stratifying patients. Several stratifications have been reported, including mechanism of onset, stage of disease progression,
involved joints, inflammatory levels, and effusion. Most of these methods revealed two to three unique subsets of osteoarthritis.
Osteoarthritic joints may be stratified by an array of variables, some transient and others consistent throughout the disease
process. Future research needs to continue to explore stratification techniques since these may be the key to optimizing palliative
interventions and developing disease-modifying interventions for subsets within this heterogeneous disease. 相似文献
76.
Yann Philippe Charles Bruno Barbe R��my Beaujeux Fazel Boujan Jean-Paul Steib 《Surgical and radiologic anatomy : SRA》2011,33(1):3-9
Purpose
The aim of this study was to describe the preoperative topography of the Adamkiewicz artery and the blood supply of the lumbosacral spinal cord in patients who underwent spinal surgery. The relevance for anterior approaches of the thoracolumbar spine was then analyzed. 相似文献77.
B. Cagnie T. Barbe P. Vandemaele E. Achten D. Cambier L. Danneels 《European spine journal》2009,18(5):704-709
All muscles of the neck have a role in motion and postural control of the cervical region. The aim of this study was to investigate
the difference in muscle/fat index between (1) cervical flexors and extensors and (2) deep and superficial neck muscles. Twenty-six
healthy subjects participated in the study. Magnetic resonance imaging (MRI) was used to quantify muscle fat indices in different
cervical flexor and extensor muscles at the C4–C5 level. Overall, the ventral muscles had a significantly lower fat content
compared with the dorsal muscles (P ≤ 0.001). For the cervical extensors, significant differences between the muscle/fat index of the deep and superficial muscles
were found (P ≤ 0.001). For the cervical flexors, there were no significant differences between the different muscles. The higher fat content
in the dorsal muscles can be explained by a discrepancy in function between the spine extensors and flexors, reflected in
a different muscle fiber distribution. The rather small differences between superficial and deep neck muscles are in line
with recent findings that have demonstrated that both muscles groups exhibit phasic activity during isometric muscles contractions
and the presumption that there is no difference in fiber type distribution between superficial and deep neck muscles. 相似文献
78.
Cailhol L Allen M Moncany AH Cicotti A Virgillito S Barbe RP Lazignac C Damsa C 《General hospital psychiatry》2007,29(1):42-44
OBJECTIVE: In spite of much effort to create guidelines on the management of violent behavior (VB) in emergency departments, little is known about the impact of such guidelines on a real-life emergency environment. The aim of this study is to investigate the impact of a staff educational crisis intervention (SECI) on the reduction of VB in patients admitted to emergency departments following drug suicidal attempt. METHOD: The impact of a SECI on VB of patient consulting the ER following a drug suicide attempt was assessed by comparing the occurrence of VB before (5 months) and after (5 months) the introduction of a SECI. RESULTS: A significant reduction in VB (from 17.32% to 7.14%) was found with the comparison of two 5-month periods: before (254 patients) and after (224 patients) the introduction of a SECI program (chi(2)=11.238; P=.0008). CONCLUSION: These preliminary data suggest the need for further prospective randomized studies aiming to prevent VB in emergency departments by developing specific SECI programs. 相似文献
79.
Silvio ST Tafuri Domenico DM Martinelli Giovanni GC Caputi Annamaria AA Arbore Cinzia CG Germinario Rosa RP Prato 《BMC health services research》2009,9(1):100-5
Background
Mandatory vaccination has contributed to the success of immunisation programmes but voluntary vaccination allows people to be responsible for their own health. There are benefits from both policies and the arguments between them remain subject to debate within and without the scientific community, both nationally and internationally. The aim of this study is to assess the opinions of those who actually work in the Vaccination Service. 相似文献80.
Staals J Pieters BM Knottnerus IL Rouhl RP van Oostenbrugge RJ Delanghe JR Lodder J 《Current neurovascular research》2008,5(3):153-158
Haptoglobin (Hp) 2-2 phenotype has been associated with peripheral and coronary artery disease and risk of vascular complications in diabetic patients, but any association of Hp polymorphism with cerebrovascular disease has not been explored so far. We aimed to study Hp polymorphism in a sample of 124 patients with a rather homogeneous type of cerebrovascular disease, namely first symptomatic lacunar stroke due to small vessel disease, in comparison with a large (n=918) control group. Hp phenotypes were determined using starch gel electrophoresis. Hp1 allele frequency was significantly higher in patients than in controls (0.480 vs. 0.395, p<0.05), mainly due to a lower Hp2-2 phenotype frequency (25.0 vs. 36.3 %; OR 0.59; 95%CI 0.38-0.90; p<0.05). This was even more pronounced in younger (相似文献