全文获取类型
收费全文 | 2436篇 |
免费 | 138篇 |
国内免费 | 43篇 |
专业分类
耳鼻咽喉 | 52篇 |
儿科学 | 64篇 |
妇产科学 | 30篇 |
基础医学 | 210篇 |
口腔科学 | 120篇 |
临床医学 | 183篇 |
内科学 | 374篇 |
皮肤病学 | 43篇 |
神经病学 | 168篇 |
特种医学 | 188篇 |
外科学 | 570篇 |
综合类 | 162篇 |
预防医学 | 141篇 |
眼科学 | 21篇 |
药学 | 178篇 |
1篇 | |
中国医学 | 8篇 |
肿瘤学 | 104篇 |
出版年
2023年 | 24篇 |
2022年 | 36篇 |
2021年 | 64篇 |
2020年 | 49篇 |
2019年 | 48篇 |
2018年 | 66篇 |
2017年 | 50篇 |
2016年 | 52篇 |
2015年 | 56篇 |
2014年 | 84篇 |
2013年 | 109篇 |
2012年 | 125篇 |
2011年 | 134篇 |
2010年 | 79篇 |
2009年 | 85篇 |
2008年 | 102篇 |
2007年 | 104篇 |
2006年 | 97篇 |
2005年 | 81篇 |
2004年 | 82篇 |
2003年 | 70篇 |
2002年 | 64篇 |
2001年 | 63篇 |
2000年 | 67篇 |
1999年 | 53篇 |
1998年 | 57篇 |
1997年 | 51篇 |
1996年 | 49篇 |
1995年 | 27篇 |
1994年 | 29篇 |
1993年 | 29篇 |
1992年 | 36篇 |
1991年 | 41篇 |
1990年 | 33篇 |
1989年 | 46篇 |
1988年 | 31篇 |
1987年 | 28篇 |
1986年 | 47篇 |
1985年 | 37篇 |
1984年 | 23篇 |
1983年 | 14篇 |
1982年 | 27篇 |
1981年 | 12篇 |
1980年 | 17篇 |
1979年 | 11篇 |
1978年 | 12篇 |
1977年 | 15篇 |
1976年 | 15篇 |
1975年 | 12篇 |
1974年 | 17篇 |
排序方式: 共有2617条查询结果,搜索用时 15 毫秒
71.
72.
73.
Parathyroid hormone 1–34 enhances extracellular matrix deposition and organization during flexor tendon repair 下载免费PDF全文
Daniel J. Lee Richard D. Southgate Youssef M. Farhat Alayna E. Loiselle Warren C. Hammert Hani A. Awad Regis J. O'Keefe 《Journal of orthopaedic research》2015,33(1):17-24
Parathyroid hormone (PTH) 1–34 is known to enhance fracture healing. Tendon repair is analogous to bone healing in its dependence on the proliferation and differentiation of mesenchymal stem cells, matrix formation, and tissue remodeling.1,2,3 We hypothesized that PTH 1–34 enhances tendon healing in a flexor digitorum longus (FDL) tendon repair model. C57Bl/6J mice were treated with either intraperitoneal PTH 1–34 or vehicle‐control (PBS). Tendons were harvested at 3–28 days for histology, gene expression, and biomechanical testing. The metatarsophalangeal joint range of motion was reduced 1.5–2‐fold in PTH 1–34 mice compared to control mice. The gliding coefficient, a measure of adhesion formation, was 2–3.5‐fold higher in PTH 1–34 mice. At 14 days post‐repair, the tensile strength was twofold higher in PTH 1–34 specimens, but at 28 days there were no differences. PTH 1–34 mice had increased fibrous tissue deposition that correlated with elevated expression of collagens and fibronectin as seen on quantitative PCR. PTH 1–34 accelerated the deposition of reparative tissue but increased adhesion formation. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 33:17–24, 2015. 相似文献
74.
Normén L Shaw CA Fink CS Awad AB 《Current Medicinal Chemistry - Cardiovascular & Hematological Agents》2004,2(1):1-12
Phytosterols and omega-3 fatty acids (n-3) are natural food ingredients with potential cardiovascular benefits. Phytosterols inhibit cholesterol absorption, thereby reducing total cholesterol (TC) and LDL-cholesterol levels. Numerous clinical studies have shown that a daily intake of 1.5-2.0 g of phytosterols can result in a 10-15 % reduction in LDL levels, while consumption of n-3 is associated with a significant reduction in plasma triglyceride (TG) concentrations. Furthermore, n-3 may also beneficially modify a number of other risk factors of coronary heart disease (CHD). Thus, it is reasonable to suggest that combination of phytosterols and n-3 may further reduce cardiovascular risk factors. Esterification of phytosterols with non-n-3 fatty acids has substantially improved their incorporation into a variety of foods without affecting the efficacy of phytosterols. Therefore, it is assumed that esterification of phytosterols with n-3 may have advantages for both food industry and health. Evidence suggests that this combination is effective in reducing the levels of several cardiovascular risk factors including TC and TG concentrations, pro-aggregatory factors, arrhythmic eicosanoid and thromboxane A2 levels. In this mini-review, we have critically reviewed and summarized data from clinical and animal studies in which phytosterols and n-3, alone or in combination, were used. We have also provided information on structure-function relationship for these two natural compounds. Biological properties of several phytosterol derivatives including phytosterol-glucoside have been also discussed. Although the animal studies are supportive of this combination therapy, human studies are needed to address its long term effects. 相似文献
75.
76.
Amina Awad Hussien Shaker Wael Shendy Manal Fahmy 《Journal of Physical Therapy Science》2015,27(7):2195-2200
[Purpose] This study investigated the effect of shoulder girdle strengthening,
particularly the scapular muscles, on poststroke trunk alignment. [Subjects and Methods]
The study involved 30 patients with residual hemiparesis following cerebrovascular stroke.
Patient assessment included measuring shoulder muscle peak torque, scapular muscles peak
force, spinal lateral deviation angle, and motor functional performance. Patients were
randomly allocated either to the control group or the study group and received an
18-session strengthening program including active resisted exercises for shoulder
abductors and external rotators in addition to trunk control exercises. The study group
received additional strengthening exercises for the scapular muscles. [Results] The two
groups showed significant improvement in strength of all shoulder and scapular muscles,
with higher improvement in the study group. Similarly, the lateral spinal deviation angles
significantly improved in both groups, with significantly higher improvement in the study
group. Transfer activity, sitting balance, upper limb functions, and hand movements
significantly improved in the two groups, with higher improvement in the latter two
functions in the study group. [Conclusion] Strengthening of shoulder girdle muscles,
particularly scapular muscles, can significantly contribute to improving the postural
alignment of the trunk in patients with poststroke hemiparesis.Key words: Stroke, Scapular muscles strengthening, Lateral trunk alignment 相似文献
77.
78.
79.
Ahmed S. BaHammam Suhail S. Alassiri Aisha H. Al-Adab Ibrahim M. Alsadhan Abdullah M. Altheyab Abdalla H. Alrayes Mohammad M. Alkhawajah Awad H. Olaish 《Saudi medical journal》2015,36(8):911-919
Objectives:
To evaluate continuous positive airway pressure (CPAP) compliance and define predictors of CPAP compliance among Saudi patients with obstructive sleep apnea (OSA) after applying an educational program.Methods:
This prospective cohort study included consecutive patients diagnosed to have OSA based on polysomnography between January 2012 and January 2014 in King Saud University, Riyadh, Kingdom of Saudi Arabia. All patients had educational sessions on OSA and CPAP therapy before sleep study, and formal hands-on training on CPAP machines on day one, day 7, and day 14 after diagnosis. The follow-up in the clinic was carried out at one, 4, and 10 months after initiating CPAP therapy. Continuous positive airway pressure compliance was assessed objectively. Logistic regression model was used to assess the predictors of CPAP adherence.Results:
The study comprised 156 patients with a mean age of 51.9±12.1 years, body mass index of 38.4±10.6 kg/m2, and apnea hypopnea index of 63.7±39.3 events/hour. All patients were using CPAP at month one, 89.7% at month 4, and 83% at month 10. The persistence of CPAP-related side effects and comorbid bronchial asthma remained as independent predictors of CPAP compliance at the end of the study.Conclusion:
With intensive education, support, and close monitoring, more than 80% of Saudi patients with OSA continued to use CPAP after 10 months of initiating CPAP therapy.Continuous positive airway pressure (CPAP) is a standard, safe, and efficacious treatment for obstructive sleep apnea (OSA), a common disorder with established harm to quality of life and adverse consequences for cardiovascular health.1 Obstructive sleep apnea is characterized by recurrent partial (hypopnea) or complete (apnea) upper airway obstruction during sleep. These recurrent respiratory events usually cause intermittent hypoxemia and sleep fragmentation.2 Recent data demonstrated that the estimated prevalence of moderate to severe OSA ranges from 10-17% in middle-aged and elderly men.3 In Saudi Arabia, 3 out of 10 middle-aged Saudi men and 4 out of 10 middle-aged Saudi women are at high risk of having OSA.4,5 The mainstay medical treatment for OSA is CPAP therapy.6 Among various available therapeutic modalities for OSA, CPAP remains the most effective treatment.6 Continuous positive airway pressure is a machine that applies positive airway pressure to the upper air passages via a mask fitted on the mouth or nose to keep the throat open.6 Previous studies in Western countries showed that OSA patients on CPAP therapy use their machines on average from 4.5 to 5.5 hours per night with compliance rates ranging from 30-85%.7,8 Several studies have been conducted to define factors that influence, or predict CPAP use and adherence, and reported conflicting results.6 Moreover, several studies reported that race might influence CPAP adherence. For example, available data suggest lower CPAP adherence among African Americans than Caucasians.9 An earlier study that assessed CPAP compliance subjectively (self-reports) among Saudi patients with OSA after 3 months of initiation of CPAP therapy revealed an overall compliance rate of 39%.10 However, self-reports have been shown to overestimate CPAP use by approximately one hour/night when compared with objectively measured CPAP use.11 In general, there are very few data on objectively assessed long-term CPAP compliance in the literature. Moreover, there is a lack of previous study objectively addressing the rate of CPAP compliance, the predictors of good compliance, and the side effects of CPAP treatment in Saudi OSA patients. Therefore, we established in our center an educational program for patients with OSA and easily accessible medical support, and close follow-up of CPAP compliance. This study was conducted to evaluate CPAP compliance and to define predictors of CPAP compliance among Saudi patients with OSA after applying the new educational program. 相似文献80.