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Massive hemobilia secondary to a needle liver biopsy developed in a 16-year-old boy with Hodgkin's disease. Cholecystectomy and common bile duct drainage failed to control the condition and the patients bled massively; management of the hemobilia was effected with left hepatic artery ligation. A review of the literature is presented, with a brief discussion of the clinical picture, pathophysiology, diagnosis, and management of this condition. 相似文献
33.
Pharmacodynamic and genomic markers associated with response to the XPO1/CRM1 inhibitor selinexor (KPT‐330): A report from the pediatric preclinical testing program 下载免费PDF全文
Edward F. Attiyeh MD John M. Maris MD Richard Lock PhD C. Patrick Reynolds MD PhD Min H. Kang PharmD Hernan Carol PhD Richard Gorlick MD E. Anders Kolb MD Stephen T. Keir PhD Jianrong Wu PhD Yosef Landesman PhD Sharon Shacham PhD MBA Dmitry Lyalin PhD Raushan T. Kurmasheva PhD Peter J. Houghton PhD Malcolm A. Smith MD PhD 《Pediatric blood & cancer》2016,63(2):276-286
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G Schleiermacher V Mosseri W B London J M Maris G M Brodeur E Attiyeh M Haber J Khan A Nakagawara F Speleman R Noguera G P Tonini M Fischer I Ambros T Monclair K K Matthay P Ambros S L Cohn A D J Pearson 《British journal of cancer》2012,107(8):1418-1422
Background:
In the INRG dataset, the hypothesis that any segmental chromosomal alteration might be of prognostic impact in neuroblastoma without MYCN amplification (MNA) was tested.Methods:
The presence of any segmental chromosomal alteration (chromosome 1p deletion, 11q deletion and/or chromosome 17q gain) defined a segmental genomic profile. Only tumours with a confirmed unaltered status for all three chromosome arms were considered as having no segmental chromosomal alterations.Results:
Among the 8800 patients in the INRG database, a genomic type could be attributed for 505 patients without MNA: 397 cases had a segmental genomic type, whereas 108 cases had an absence of any segmental alteration. A segmental genomic type was more frequent in patients >18 months and in stage 4 disease (P<0.0001). In univariate analysis, 11q deletion, 17q gain and a segmental genomic type were associated with a poorer event-free survival (EFS) (P<0.0001, P=0.0002 and P<0.0001, respectively). In multivariate analysis modelling EFS, the parameters age, stage and a segmental genomic type were retained in the model, whereas the individual genetic markers were not (P<0.0001 and RR=2.56; P=0.0002 and RR=1.8; P=0.01 and RR=1.7, respectively).Conclusion:
A segmental genomic profile, rather than the single genetic markers, adds prognostic information to the clinical markers age and stage in neuroblastoma patients without MNA, underlining the importance of pangenomic studies. 相似文献37.
Bosse KR Diskin SJ Cole KA Wood AC Schnepp RW Norris G Nguyen le B Jagannathan J Laquaglia M Winter C Diamond M Hou C Attiyeh EF Mosse YP Pineros V Dizin E Zhang Y Asgharzadeh S Seeger RC Capasso M Pawel BR Devoto M Hakonarson H Rappaport EF Irminger-Finger I Maris JM 《Cancer research》2012,72(8):2068-2078
The mechanisms underlying genetic susceptibility at loci discovered by genome-wide association study (GWAS) approaches in human cancer remain largely undefined. In this study, we characterized the high-risk neuroblastoma association at the BRCA1-related locus, BARD1, showing that disease-associated variations correlate with increased expression of the oncogenically activated isoform, BARD1β. In neuroblastoma cells, silencing of BARD1β showed genotype-specific cytotoxic effects, including decreased substrate-adherence, anchorage-independence, and foci growth. In established murine fibroblasts, overexpression of BARD1β was sufficient for neoplastic transformation. BARD1β stabilized the Aurora family of kinases in neuroblastoma cells, suggesting both a mechanism for the observed effect and a potential therapeutic strategy. Together, our findings identify BARD1β as an oncogenic driver of high-risk neuroblastoma tumorigenesis, and more generally, they illustrate how robust GWAS signals offer genomic landmarks to identify molecular mechanisms involved in both tumor initiation and malignant progression. The interaction of BARD1β with the Aurora family of kinases lends strong support to the ongoing work to develop Aurora kinase inhibitors for clinically aggressive neuroblastoma. 相似文献
38.
K. Turaga E. Levine R. Barone R. Sticca N. Petrelli L. Lambert G. Nash M. Morse R. Adbel-Misih H. R. Alexander F. Attiyeh D. Bartlett A. Bastidas T. Blazer Q. Chu K. Chung L. Dominguez-Parra N. J. Espat J. Foster K. Fournier R. Garcia M. Goodman N. Hanna L. Harrison R. Hoefer M. Holtzman J. Kane D. Labow B. Li A. Lowy P. Mansfield E. Ong C. Pameijer J. Pingpank M. Quinones R. Royal G. Salti A. Sardi P. Shen J. Skitzki J. Spellman J. Stewart J. Esquivel 《Annals of surgical oncology》2014,21(5):1501-1505
Background
The American Society of Peritoneal Surface Malignancies (ASPSM) is a consortium of cancer centers performing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC). This is a position paper from the ASPSM on the standardization of the delivery of HIPEC.Methods
A survey was conducted of all cancer centers performing HIPEC in the United States. We attempted to obtain consensus by the modified method of Delphi on seven key HIPEC parameters: (1) method, (2) inflow temperature, (3) perfusate volume, (4) drug, (5) dosage, (6) timing of drug delivery, and (7) total perfusion time. Statistical analysis was performed using nonparametric tests.Results
Response rates for ASPSM members (n = 45) and non-ASPSM members (n = 24) were 89 and 33 %, respectively. Of the responders from ASPSM members, 95 % agreed with implementing the proposal. Majority of the surgical oncologists favored the closed method of delivery with a standardized dual dose of mitomycin for a 90-min chemoperfusion for patients undergoing cytoreductive surgery for peritoneal carcinomatosis of colorectal origin.Conclusions
This recommendation on a standardized delivery of HIPEC in patients with colorectal cancer represents an important first step in enhancing research in this field. Studies directed at maximizing the efficacy of each of the seven key elements will need to follow. 相似文献39.
Mohammad Al Efishat Marc A. Attiyeh Anne A. Eaton Mithat G?nen Anne M. Covey Michael I. DAngelica Ronald P. DeMatteo T. Peter Kingham Vinod Balachandran William R. Jarnagin Hans Gerdes Peter J. Allen Mark A. Schattner 《HPB : the official journal of the International Hepato Pancreato Biliary Association》2019,21(4):434-443
Background
Post-operative peripancreatic fluid collection (PFC) is a common complication following pancreatic resection which can be managed with endoscopic or percutaneous drainage.Methods
Patients who underwent either endoscopic or percutaneous drainage of post-operative PFC were extracted from a prospectively-maintained database. The two groups were matched for surgery type, presence of a surgical drain and timing of drainage.Results
Thirty-nine matched patients were identified in each group with a median age of 62 years. For primary drainage, technical success was achieved in almost all patients in both endoscopic and percutaneous groups (100% and 97%, p = NS); clinical success was achieved in 67% and 59%, respectively (p = 0.63). At least one “salvage” drainage procedure was required in 13 endoscopic patients versus 16 in the percutaneous group. Clinical success was achieved following the first salvage. Procedure in 85% of the endoscopic patients and 88% of the percutaneous patients (p = 0.62). Stent/drain duration (59 vs 33 days, p < 0.001) and number of post-procedural CT studies (2 vs 1, p = 0.02) were significantly higher in the endoscopic group. There was no difference in length of stay, complication, or recurrence between the two groups.Conclusion
Endoscopic drainage of post-operative PFC appears to be safe and effective with comparable success rates and outcomes to percutaneous drainage. 相似文献40.
Hepatic resection for metastasis from colorectal cancer 总被引:6,自引:4,他引:2
Dr. Fadi F. Attiyeh M.D. Harold J. Wanebo M.D. Maus W. Stearns M.D. 《Diseases of the colon and rectum》1978,21(3):160-162
Summary Twenty-five patients who had hepatic metastases from carcinomas of the colon and rectum had resection for cure at Memorial
Hospital, with a determinate five-year survival rate of 40 per cent, and 10-year survival rate of 28 per cent. Most of the
hepatic metastatic lesions were solitary, small, and peripheral, and were treated with simple wedge resection. These favorable
results justify an aggressive approach to solitary metastatic lesions in the liver. 相似文献