RSA fluctuation in major depressive disorder

Cardiac vagal control, as measured by indices of respiratory sinus arrhythmia (RSA), has been investigated as a marker of impaired self-regulation in mental disorders, including depression. Past work in depressed samples has focused on deficits in resting RSA levels, with mixed results. This study tested the hypothesis that depression involves abnormal RSA fluctuation. RSA was measured in depressed and healthy control participants during rest and during two reactivity tasks, each followed by a recovery period. Relative to controls, depressed persons exhibited lower resting RSA levels as well as less RSA fluctuation, primarily evidenced by a lack of task-related vagal suppression. Group differences in RSA fluctuation were not accounted for by differences in physical health or respiration, whereas group differences in resting RSA level did not survive covariate analyses. Depression may involve multiple deficits in cardiac vagal control.     

Number needed to treat and costs per responder among biologic treatments for moderate-to-severe psoriasis: a network meta-analysis

Background: The clinical benefits of biologic therapies for moderate-to-severe psoriasis are well established, but wide variations exist in patient response.

Objectives: To determine the number needed to treat (NNT) to achieve a 75% and 90% reduction in the Psoriasis Area and Severity Index (PASI-75/90) with FDA-approved agents and evaluate the incremental cost per PASI-75 or PASI-90 responder.

Methods: The relative probabilities of achieving PASI-75 and PASI-90, as well as NNTs, were estimated using a network meta-analysis. Costs (2017 USD) included drug acquisition and administration. The incremental cost per PASI-75 or PASI-90 responder for each treatment was estimated for the clinical trial period, and annually.

Results: Compared with supportive care, the NNT to achieve PASI-75 was 1.18 for ixekizumab, 1.29 for secukinumab 300?mg, 1.37 for infliximab, 1.48 for adalimumab, 1.53 for secukinumab 150?mg, 1.58 for ustekinumab, 2.25 for etanercept, and 3.71 for apremilast. The one-year incremental cost per PASI-75 responder relative to supportive care was $59,830 for infliximab, $88,775 for secukinumab 300?mg, $91,837 for adalimumab, $95,898 for ixekizumab, $97,363 for ustekinumab, $105,131 for secukinumab 150?mg, $129,665 for apremilast, and $159,328 for etanercept. Results were similar for PASI-90.

Conclusion: The NNT and incremental cost per responder are meaningful ways to assess comparative effectiveness and cost effectiveness among psoriasis treatments.     

Factors that affect functional status in patients with cancer-related pain

Cancer-related pain in outpatient adult populations remains high and has a direct effect on functional status. Factors that affect functional status have been explored separately, but the inter-relatedness of those factors has not been examined. Using a cross-sectional design, the purpose of this study was to examine the relationships between pain level, beliefs about pain, symptom distress, perceived control over pain, and functional status in 304 ambulatory cancer patients who experienced cancer-related pain within the past 2 weeks. Participants completed standardized questionnaires during regularly scheduled clinic visits. Patient's pain level was positively related to increased distress and decreased perceived control over pain and functional status. Structural equation modeling indicated that symptom distress mediated the relation between pain level and functional status. Perceived control over pain had a direct effect on symptom distress and mediated the effect of beliefs about pain and pain level on symptom distress. Patients' perceived control over pain may be an important component in pain management. The direct and mediating effects of perceived control and symptom distress suggest areas of further research. Interventions to increase knowledge and decrease barriers to pain control have the potential for increasing perceived control over pain.     

Mandibular first molar relation to variable lower face skeletal components

OBJECTIVE: To evaluate the position of the mandibular first permanent molar in the mandible relative to several factors. MATERIALS AND METHODS: A total of 185 untreated Class I and Class II patients were randomly selected from a sample of 350 patients from a single office. The palatal and mandibular planes were related to Frankfort horizontal to create the interjaw or "B" angle. Age and the mesial contact of the mandibular first molars were used. The landmarks were projected at right angles to the Frankfort horizontal for effective mandibular dimension lengths. Actual-length dimensions were projected at right angles to the mandibular plane. Pearson product moment correlation coefficients were computed to evaluate the effect of age, cranial length, and mandibular contribution to the molar's sagittal position in the mandible. Significance was reported only when P < .05 to determine a 95% confidence level. RESULTS: Statistically significant positive correlations indicated that the mandibular molar is located more forward with increasing age, longer mandibular body length, and increasing posterior facial height. In contrast, significant negative correlations to the interjaw, mandibular plane, ramal inclination angles, and the linear ramal contribution corresponded to a more posterior position of the molar with increasing angles. CONCLUSIONS: The mandibular first permanent molar is located more anteriorly with an older patient, a longer mandibular body, greater posterior facial height, and an acute interjaw angle. In contrast, an increase in the forward tip of the ramus places the molar in a more posterior location.     

Technological advances in pediatrics: challenges for parents and nurses

Ongoing technological advances in pediatrics are improving the survival rates among babies born with life-threatening anomalies. For these neonates, surgeries like brain shunts, trachea, gut and heart reconstruction, and organ transplants are replacing palliative care. Although parents and health care professionals alike are celebrating the successes, advancing technology also raises issues for everyone involved. This paper incorporates Dunst and Trivette's Effective Helpgiving framework and the Calgary Family Intervention Model to recommend nursing care that moves beyond life-saving highly technical surgical procedures and responds to the challenges parents face with their children with complex congenital heart disease, for example, who have "beat the odds."     

Comparison of stroke volume estimation for non-steady-state and steady-state graded exercise testing

The stroke volume (SV) during exercise is an important index of the heart's functional capacity. A new method has been developed for the non-invasive estimation of exercise SV (SVex). It requires the determination of the slope for the oxygen uptake versus heart rate relationship in the steady state of graded exercise testing (GXT). The product of the slope and a constant (reciprocal of an assumed value of the arterial oxygen content) equals an estimated value for SVex. It was validated in a previous study using invasive measurements while subjects were performing steady-state GXT. However, currently the most commonly used GXT protocols are non-steady state, e.g. protocols with 1-min increment durations. We tested the hypothesis that SVex is the same for steady-state and non-steady-state GXT. A total of 30 subjects (15 males and 15 females) served as subjects for the study. Each subject performed two GXTs on different days with different increment durations - 1 and 4 min. Ventilation and gas exchange were measured with the Vacumed metabolic cart. For the male subjects, the mean (SD) SVex values for the 1- and 4-min GXTs were 155.4 (39.5) and 134.6 (27.5) ml, respectively. The corresponding values for the female subjects were 151.6 (37.6) and 134.3 (36.4) ml. Paired t-test analysis demonstrated that for both genders the mean SVex for the 1-min GXT was significantly larger than the 4-min GXT mean value (P<0.05). Hence, the commonly used 1-min GXT does not yield the same values for SVex as the steady-state GXT.