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991.
992.
Evandro Tinoco Mesquita Antonio Jose Lagoeiro Jorge Celso Vale de Souza Junior Jo?o Paulo Pedroza Cassino 《Arquivos brasileiros de cardiologia》2014,102(5):510-517
Heart failure with normal ejection fraction (HFNEF) is currently the most
prevalent clinical phenotype of heart failure. However, the treatments available
have shown no reduction in mortality so far. Advances in the
omics sciences and techniques of high data processing used
in molecular biology have enabled the development of an integrating approach to
HFNEF based on systems biology.This study aimed at presenting a systems-biology-based HFNEF model using the
bottom-up and top-down approaches.A literature search was conducted for studies published between 1991 and 2013
regarding HFNEF pathophysiology, its biomarkers and systems biology. A
conceptual model was developed using bottom-up and top-down approaches of
systems biology.The use of systems-biology approaches for HFNEF, a complex clinical syndrome, can
be useful to better understand its pathophysiology and to discover new
therapeutic targets. 相似文献
993.
Vanessa Cristina Miranda Takahagi Daniela Caetano Costa Júlio César Crescêncio Louren?o Gallo Junior 《Arquivos brasileiros de cardiologia》2014,102(3):288-294
Background
Characterized as a sudden and temporary loss of consciousness and postural tone, with quick and spontaneous recovery, syncope is caused by an acute reduction of systemic arterial pressure and, therefore, of cerebral blood flow. Unsatisfactory results with the use of drugs allowed the nonpharmacological treatment of neurocardiogenic syncope was contemplated as the first therapeutic option.Objectives
To compare, in patients with neurocardiogenic syncope, the impact of a moderate intensity aerobic physical training (AFT) and a control intervention on the positivity of head-up tilting test (HUT) and orthostatic tolerance time.Methods
Were studied 21 patients with a history of recurrent neurocardiogenic syncope and HUT. The patients were randomized into: trained group (TG), n = 11, and control group (CG), n = 10. The TG was submitted to 12 weeks of AFT supervised, in cycle ergometer, and the CG to a control procedure that consisted in 15 minutes of stretching and 15 minutes of light walk.Results
The TG had a positive effect to physical training, with a significant increase in peak oxygen consumption. The CG did not show any statistically significant change before and after the intervention. After the intervention period, 72.7% of the TG sample had negative results to the HUT, not having syncope in the revaluation.Conclusion
The program of supervised aerobic physical training for 12 weeks was able to reduce the number of positive HUT, as it was able to increase tolerance time in orthostatic position during the HUT after the intervention period. 相似文献994.
995.
Mario Strazzabosco Paolo A. Cortesi Sara Conti Stefano Okolicsanyi Matteo Rota Antonio Ciaccio Paolo Cozzolino Carla Fornari Marta Gemma Luciana Scalone Giancarlo Cesana Luca Fabris Michele Colledan Stefano Fagiuoli Gaetano Ideo Claudio Zavaglia Giovanni Perricone Luca M. Munari Lorenzo G. Mantovani Luca S. Belli 《Liver international》2020,40(1):60-73
996.
997.
998.
999.