全文获取类型
收费全文 | 58111篇 |
免费 | 2763篇 |
国内免费 | 419篇 |
专业分类
耳鼻咽喉 | 681篇 |
儿科学 | 1207篇 |
妇产科学 | 1514篇 |
基础医学 | 6997篇 |
口腔科学 | 2931篇 |
临床医学 | 4290篇 |
内科学 | 15876篇 |
皮肤病学 | 1133篇 |
神经病学 | 4852篇 |
特种医学 | 1440篇 |
外国民族医学 | 2篇 |
外科学 | 8285篇 |
综合类 | 220篇 |
一般理论 | 13篇 |
预防医学 | 3766篇 |
眼科学 | 955篇 |
药学 | 3338篇 |
中国医学 | 174篇 |
肿瘤学 | 3619篇 |
出版年
2024年 | 50篇 |
2023年 | 444篇 |
2022年 | 1082篇 |
2021年 | 1932篇 |
2020年 | 1061篇 |
2019年 | 1490篇 |
2018年 | 1999篇 |
2017年 | 1341篇 |
2016年 | 1496篇 |
2015年 | 1723篇 |
2014年 | 2386篇 |
2013年 | 3060篇 |
2012年 | 4754篇 |
2011年 | 4688篇 |
2010年 | 2605篇 |
2009年 | 2234篇 |
2008年 | 3854篇 |
2007年 | 3975篇 |
2006年 | 3654篇 |
2005年 | 3515篇 |
2004年 | 3155篇 |
2003年 | 2806篇 |
2002年 | 2499篇 |
2001年 | 438篇 |
2000年 | 382篇 |
1999年 | 449篇 |
1998年 | 435篇 |
1997年 | 384篇 |
1996年 | 326篇 |
1995年 | 312篇 |
1994年 | 260篇 |
1993年 | 192篇 |
1992年 | 220篇 |
1991年 | 175篇 |
1990年 | 155篇 |
1989年 | 155篇 |
1988年 | 130篇 |
1987年 | 104篇 |
1986年 | 118篇 |
1985年 | 127篇 |
1984年 | 120篇 |
1983年 | 95篇 |
1982年 | 110篇 |
1981年 | 88篇 |
1980年 | 91篇 |
1979年 | 55篇 |
1978年 | 64篇 |
1977年 | 55篇 |
1976年 | 55篇 |
1975年 | 49篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
42.
Nelson Wolosker Guilherme Yazbek José Ribas Milanez de Campos Paulo Kauffman Augusto Ishy Pedro Puech-Leão 《Clinical autonomic research》2007,17(3):172-176
Background Sympathectomy is the treatment of choice for primary hyperhidrosis. One curious occurrence that is difficult to explain from
an anatomophysiological point of view in cases of video-assisted thoracoscopic sympathectomy (VATS) for the treatment of palmar
hyperhidrosis (PH) is the observed improvement in plantar hyperhidrosis (PLH). Nevertheless, current reports on VATS rarely
describe the effect on PLH or just give superficial data. The aim of this study was to prospectively investigate, how surgery
affects PLH in patients with PH and PLH over one-year period.
Methods From May 2003 to January 2004, 70 consecutive patients with combined PH and PLH underwent VATS at the T2, T3, or T4 ganglion
level (47 women and 23 men, with mean age of 23 years).
Results Immediately after the operation, all the patients said they were free from PH episodes, except for two patients (2.8%) who
suffered from continued PH. Compensatory hyperhidrosis (CH) of various degrees was observed in 58 (90.6%) patients after one
year. Only 13 (20.3%) suffered from severe CH. There was a great initial improvement in PLH in 50% of the cases, followed
by progressive regression, such that only 23.4% still presented that improvement after one year. The number of cases without
overall improvement increased progressively (from 17.1% to 37.5%) and the numbers with slight improvement remained stable
(32.9–39.1%). Of the 24 patients with no improvement after one year, 6 patients graded plantar sweating worse.
Conclusion Patients with PH and PLH who undergo VATS to treat their PH present a good initial improvement in PLH that reduces to a lower
level of improvement after the one-year period. 相似文献
43.
44.
Stefano Tamburin Antonio Fiaschi Domenico Idone Piergiorgio Lochner Paolo Manganotti Giampietro Zanette 《Movement disorders》2003,18(11):1316-1324
Hyperexcitability of the motor system has been reported in Parkinson's disease (PD). We evaluate how cutaneous afferents modulate motor excitability in PD patients and whether abnormal modulation is correlated to parkinsonian symptoms. Digital stimulation causes abnormal enhancement of motor responses in patients. This effect may be one of the features of motor hyperexcitability in PD. Cutaneomotor hyperexcitability correlates with clinical scores, suggesting that abnormal processing of cutaneous inputs might contribute to the pathogenesis of parkinsonian symptoms. 相似文献
45.
Eric Vivier Antonio J. da Silva Melissa Ackerly Herbert Levine Christopher E. Rudd Paul Anderson 《European journal of immunology》1993,23(8):1872-1876
The CD16: ζ: γ receptor complex allows natural killer (NK) cells to recognize and eliminate antibody-coated target cells. Whereas the ectodomain of CD16 is the receptor for Fcγ domains of immunoglobulins, disulfide-linked homo- and heterodimers composed of ζ and γ are required for the cell surface expression, and signal transduction properties of the complex. Engagement of CD16 activates the tyrosine kinase pathway, which induces the tyrosine phosphorylation of several substrates, including the ζ subunit and the phospholipase C γ-1 and γ-2 isoforms. Here we show that CD 16 stimulation of either peripheral blood NK cells, leukemic NK cells, or Jurkat transformants expressing a CD16:ζ:γ receptor complex, results in the tyrosine phosphorylation of a 70 kDa ζ-associated protein (pp70). Similarly, a 70-kDa ζ-associated phosphoprotein in T cells has been shown to be a tyrosine kinase (ZAP-70). Peptide mapping analysis indicates that the 70-kDa ζ-associated phosphoproteins from T cells and NK cells are structurally indistinguishable. We conclude that the CD16:ζ:γ complex may use a ZAP-70-related non-receptor tyrosine kinase, in the CD16 signaling cascade leading to NK cell activation. 相似文献
46.
Mutations Affecting the Rossman Fold of Isoleucyl-tRNA Synthetase Are Correlated with Low-Level Mupirocin Resistance in Staphylococcus aureus 下载免费PDF全文
Martin Antonio Neil McFerran Mark J. Pallen 《Antimicrobial agents and chemotherapy》2002,46(2):438-442
The isoleucyl-tRNA synthetase (ileS) gene was sequenced in toto from 9 and in part from 31 Staphylococcus aureus strains with various degrees of susceptibility to mupirocin. All strains for which the mupirocin MIC was greater than 8 microg/ml contained point mutations affecting the Rossman fold via Val-to-Phe changes at either residue 588 (V588F) or residue 631 (V631F). The importance of the V588F mutation was confirmed by an allele-specific PCR survey of 32 additional strains. Additional mutations of uncertain significance were found in residues clustered on the surface of the IleS protein. 相似文献
47.
Antonio F. Govoni M.D 《Clinical imaging》1992,16(4):285
48.
Ana Sánchez-Romero Israel Oliver David Costa Albina Orduña Javier Lacueva Francisco Pérez-Vicente Antonio Arroyo Rafael Calpena 《Clinical & translational oncology》2006,8(4):294-295
Lung cancer is the most prevalent malignancy in western countries and most of the patients present at advanced stages, but
single splenic metastasis is exceptional instead. We report on a case of a seventy-three-year old male presenting with non-hemoptoic
productive cough, constitutional syndrome and pain in the left lower quadrant. Physical examination and complementary radiological
and hystologycal procedures revealed the presence of an adenocarcinoma of the left lung with probable splenic metastasis.
The patient underwent splenectomy, which confirmed the diagnose of splenic metastasis of lung adenocarcinoma and, secondly,
lung resection was performed. Topics about lung cancer metastasis are discussed. 相似文献
49.
50.
Alfonso Fasano Antonio E Elia Arianna Guidubaldi Pietro A Tonali Anna Rita Bentivoglio 《Movement disorders》2007,22(4):564-566
We report a case of cervical dystonia occurring in a 33-year-old without personal history of movement disorder but with family history of essential tremor, primigravid, primiparous woman at 1 weeks' amenorrhea, resolved completely after delivery in the course of 3 months. Dystonia never recurred in the following 5 years. Several neurological disorders are known to occur or worsen during pregnancy. As far as we know, this is the second reported case of dystonia occurring during pregnancy, thus confirming that dystonia gravidarum represents a new entity and should be considered in women of reproductive age affected by dystonia, especially when presenting with rapid-onset cervical dystonia. 相似文献