首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   51311篇
  免费   3903篇
  国内免费   177篇
耳鼻咽喉   473篇
儿科学   1262篇
妇产科学   1166篇
基础医学   6940篇
口腔科学   1058篇
临床医学   5093篇
内科学   9869篇
皮肤病学   903篇
神经病学   5177篇
特种医学   1773篇
外科学   8448篇
综合类   672篇
现状与发展   1篇
一般理论   46篇
预防医学   4464篇
眼科学   1167篇
药学   3317篇
  2篇
中国医学   117篇
肿瘤学   3443篇
  2023年   254篇
  2022年   394篇
  2021年   1060篇
  2020年   676篇
  2019年   985篇
  2018年   1195篇
  2017年   877篇
  2016年   890篇
  2015年   1036篇
  2014年   1623篇
  2013年   2164篇
  2012年   3469篇
  2011年   3646篇
  2010年   2049篇
  2009年   1799篇
  2008年   3361篇
  2007年   3512篇
  2006年   3308篇
  2005年   3241篇
  2004年   3106篇
  2003年   2922篇
  2002年   2741篇
  2001年   621篇
  2000年   570篇
  1999年   590篇
  1998年   580篇
  1997年   513篇
  1996年   497篇
  1995年   418篇
  1994年   405篇
  1993年   368篇
  1992年   407篇
  1991年   382篇
  1990年   332篇
  1989年   283篇
  1988年   354篇
  1987年   301篇
  1986年   274篇
  1985年   277篇
  1984年   268篇
  1983年   260篇
  1982年   320篇
  1981年   281篇
  1980年   241篇
  1979年   184篇
  1978年   215篇
  1977年   188篇
  1976年   163篇
  1975年   176篇
  1974年   157篇
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
991.
992.
993.

Background

Poststroke distal lower limb spasticity impairs mobility, limiting activities of daily living and requiring additional caregiver time.

Objective

To evaluate the efficacy, safety, and sustained benefit of onabotulinumtoxinA in adults with poststroke lower limb spasticity (PSLLS).

Design

A multicenter, randomized, double-blind, phase 3, placebo-controlled trial (NCT01575054).

Setting

Sixty study centers across North America, Europe, Russia, the United Kingdom, and South Korea.

Patients

Adult patients (18-65 years of age) with PSLLS (Modified Ashworth Scale [MAS] ≥3) of the ankle plantar flexors and the most recent stroke ≥3 months before study enrollment.

Interventions

During the open-label phase, patients received ≤3 onabotulinumtoxinA treatments (≤400 U) or placebo at approximately 12-week intervals. Treatments were into the ankle plantar flexors (onabotulinumtoxinA 300 U into ankle plantar flexors; ≤100 U, optional lower limb muscles).

Main Outcome Measurements

The double-blind primary endpoint was MAS change from baseline (average score at weeks 4 and 6). Secondary measures included physician-assessed Clinical Global Impression of Change (CGI), MAS change from baseline in optional muscles, Goal Attainment Scale (GAS), and pain scale.

Results

Of 468 patients enrolled, 450 (96%) completed the double-blind phase and 413 (88%) completed the study. Small improvements in MAS observed with onabotulinumtoxinA during the double-blind phase (onabotulinumtoxinA, –0.8; placebo, –0.6, P = .01) were further enhanced with additional treatments through week 6 of the third open-label treatment cycle (onabotulinumtoxinA/onabotulinumtoxinA, –1.2; placebo/onabotulinumtoxinA, –1.4). Small improvements in CGI observed during the double-blind phase (onabotulinumtoxinA, 0.9; placebo, 0.7, P = .01) were also further enhanced through week 6 of the third open-label treatment cycle (onabotulinumtoxinA/onabotulinumtoxinA, 1.6; placebo/onabotulinumtoxinA, 1.6). Physician- and patient-assessed GAS scores improved with each subsequent treatment. No new safety signals emerged.

Conclusions

OnabotulinumtoxinA significantly improved ankle MAS, CGI, and GAS scores compared with placebo; improvements were consistent and increased with repeated treatments of onabotulinumtoxinA over 1 year in patients with PSLLS.

Level of Evidence

I  相似文献   
994.
995.
996.
997.
While it has been argued that children with autism spectrum disorders are responsive to robot-like toys, very little research has examined the impact of robot-based intervention on gesture use. These children have delayed gestural development. We used a social robot in two phases to teach them to recognize and produce eight pantomime gestures that expressed feelings and needs. Compared to the children in the wait-list control group (N?=?6), those in the intervention group (N?=?7) were more likely to recognize gestures and to gesture accurately in trained and untrained scenarios. They also generalized the acquired recognition (but not production) skills to human-to-human interaction. The benefits and limitations of robot-based intervention for gestural learning were highlighted.
  • Implications for Rehabilitation
  • Compared to typically-developing children, children with autism spectrum disorders have delayed development of gesture comprehension and production.

  • Robot-based intervention program was developed to teach children with autism spectrum disorders recognition (Phase I) and production (Phase II) of eight pantomime gestures that expressed feelings and needs.

  • Children in the intervention group (but not in the wait-list control group) were able to recognize more gestures in both trained and untrained scenarios and generalize the acquired gestural recognition skills to human-to-human interaction.

  • Similar findings were reported for gestural production except that there was no strong evidence showing children in the intervention group could produce gestures accurately in human-to-human interaction.

  相似文献   
998.

Purpose of Review

To review the etiology, classification, presentation, evaluation, treatment strategy, and outcomes in overhead athletes with partial thickness rotator cuff tears.

Recent Findings

Despite advances in surgical repair techniques, return to play following surgical repair of partial rotator cuff tears remains modest at best.

Summary

Overhead athletes may be particularly prone to rotator cuff pathology due to the supraphysiological strains within the tendon during the throwing motion, as well as mechanical stress with contact between the undersurface of the rotator cuff and the glenoid. The true prevalence of partial tears may be underestimated given the high incidence of asymptomatic tears. Both dynamic ultrasound and enhanced contrast MRI have improved our understanding of this pathology. For most overhead athletes, nonoperative management is the most common course. Despite advances in imaging, diagnosis, and surgical techniques, our ability to return these patients to their elite level is modest at best when nonoperative management fails and surgical treatment is performed. If a surgical route is needed, debridement alone is the most frequent procedure given concerns of over constraint and poor return to play with surgical repair of the partial thickness rotator cuff tear.
  相似文献   
999.
1000.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号