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Maite Aznárez‐Sanado PhD Maria A. Fernández‐Seara PhD Francis R. Loayza PhD Maria A. Pastor MD PhD 《Journal of magnetic resonance imaging : JMRI》2013,37(3):619-631
Purpose:
To elucidate differences in activity and connectivity during early learning due to the performing hand.Materials and Methods:
Twenty right‐handed subjects were recruited. The neural correlates of explicit visuospatial learning executed with the right, the left hand, and bimanually were investigated using functional magnetic resonance imaging. Connectivity analyses were carried out using the psychophysiological interactions model, considering right and left anterior putamen as index regions.Results:
A common neural network was found for the three tasks during learning. Main activity increases were located in posterior cingulate cortex, supplementary motor area, parietal cortex, anterior putamen, and cerebellum (IV–V), whereas activity decrements were observed in prefrontal regions. However, the left hand task showed a greater recruitment of left hippocampal areas when compared with the other tasks. In addition, enhanced connectivity between the right anterior putamen and motor cortical and cerebellar regions was found for the left hand when compared with the right hand task.Conclusion:
An additional recruitment of brain regions and increased striato‐cortical and striato‐cerebellar functional connections is needed when early learning is performed with the nondominant hand. In addition, access to brain resources during learning may be directed by the dominant hand in the bimanual task. J. Magn. Reson. Imaging 2013;37:619–631. © 2012 Wiley Periodicals, Inc. 相似文献998.
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Maria del C. Valdés Hernández PhD Rory J. Piper BMedSc Xin Wang MSc Ian J. Deary PhD Joanna M. Wardlaw MD 《Journal of magnetic resonance imaging : JMRI》2013,38(4):774-785
Enlarged perivascular spaces (EPVS), visible in brain MRI, are an important marker of small vessel disease and neuroinflammation. We systematically evaluated the literature up to June 2012 on possible methods for their computational assessment and analyzed confounds with lacunes and small white matter hyperintensities. We found six studies that assessed/identified EPVS computationally by seven different methods, and four studies that described techniques to automatically segment similar structures and are potentially suitable for EPVS segmentation. T2‐weighted MRI was the only sequence that identified all EPVS, but FLAIR and T1‐weighted images were useful in their differentiation. Inconsistency within the literature regarding their diameter and terminology, and overlap in shape, intensity, location, and size with lacunes, conspires against their differentiation and the accuracy and reproducibility of any computational segmentation technique. The most promising approach will need to combine various MR sequences and consider all these features for accurate EPVS determination. J. Magn. Reson. Imaging 2013;38:774–785. © 2013 Wiley Periodicals, Inc. 相似文献
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Peter A. Sims MSc MB MFCM MRCGP 《Medicine, conflict, and survival》2013,29(3):199-200
Community physicians have recently, albeit often reluctantly, been involved in preparations for nuclear war. This paper suggests an alternative: that they should use their skills in epidemiology and in preventive and social medicine in the prevention of nuclear war. 相似文献