全文获取类型
收费全文 | 309篇 |
免费 | 17篇 |
专业分类
儿科学 | 31篇 |
妇产科学 | 8篇 |
基础医学 | 47篇 |
口腔科学 | 18篇 |
临床医学 | 33篇 |
内科学 | 74篇 |
神经病学 | 43篇 |
特种医学 | 8篇 |
外科学 | 17篇 |
预防医学 | 30篇 |
药学 | 9篇 |
肿瘤学 | 8篇 |
出版年
2023年 | 3篇 |
2022年 | 5篇 |
2021年 | 2篇 |
2020年 | 2篇 |
2018年 | 3篇 |
2017年 | 2篇 |
2016年 | 5篇 |
2015年 | 4篇 |
2014年 | 6篇 |
2013年 | 11篇 |
2012年 | 16篇 |
2011年 | 26篇 |
2010年 | 13篇 |
2009年 | 9篇 |
2008年 | 23篇 |
2007年 | 24篇 |
2006年 | 10篇 |
2005年 | 19篇 |
2004年 | 19篇 |
2003年 | 14篇 |
2002年 | 18篇 |
2001年 | 5篇 |
2000年 | 2篇 |
1999年 | 4篇 |
1998年 | 5篇 |
1997年 | 7篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1994年 | 3篇 |
1993年 | 3篇 |
1992年 | 3篇 |
1991年 | 4篇 |
1990年 | 1篇 |
1989年 | 6篇 |
1988年 | 6篇 |
1987年 | 3篇 |
1986年 | 2篇 |
1985年 | 6篇 |
1984年 | 2篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1980年 | 3篇 |
1979年 | 6篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1972年 | 2篇 |
1971年 | 1篇 |
1968年 | 1篇 |
1967年 | 1篇 |
排序方式: 共有326条查询结果,搜索用时 30 毫秒
111.
Taina Laajasalo Suvi Saukkonen Janne Kivivuori Venla Salmi Jari Lipsanen Eeva T. Aronen 《Journal of adolescence》2014
The Antisocial Process Screening Device- Self-Report (APSD-SR) is a self-report measure for assessment of psychopathic traits in adolescents. The present study aimed to investigate the factor structure and internal consistency of the APSD-SR in a sample of 4855 Finnish community adolescents. A three-factor structure with factors representing impulsivity (IMP), narcissism (NAR) and callous-unemotional (CU) features was found. Internal consistency indices ranged from moderate to good. The findings provide promising data on applicability of the APSD-SR instrument to Scandinavian youth. Results have implications for researchers and clinicians interested in measuring adolescent psychopathy. 相似文献
112.
A pH, thermal, and redox potential triple-responsive expansile nanogel system (TRN), which swells at acidic pH, temperature higher than its transition temperature, and reducing environment, has been developed. TRN quickly expands from 108 nm to over 1200 nm (in diameter), achieving more than 1000-fold size enlargement (in volume), within 2 h in a reducing environment at body temperature. Sigma-2 receptor targeting-ligand functionalized TRN can effectively target head and neck tumor, and help Pc 4 targeting mitochondria inside cancer cells to achieve enhanced photodynamic therapy efficacy. 相似文献
113.
114.
115.
116.
Kristiansson K Perola M Tikkanen E Kettunen J Surakka I Havulinna AS Stancáková A Barnes C Widen E Kajantie E Eriksson JG Viikari J Kähönen M Lehtimäki T Raitakari OT Hartikainen AL Ruokonen A Pouta A Jula A Kangas AJ Soininen P Ala-Korpela M Männistö S Jousilahti P Bonnycastle LL Järvelin MR Kuusisto J Collins FS Laakso M Hurles ME Palotie A Peltonen L Ripatti S Salomaa V 《Circulation. Cardiovascular genetics》2012,5(2):242-249
117.
T Saukkonen E Savilahti M Landin-Olsson G Dahlquist 《Acta paediatrica (Oslo, Norway : 1992)》1995,84(11):1258-1261
We studied the significance of antibodies to bovine serum albumin (BSA) as a risk factor for insulin-dependent diabetes mellitus (IDDM) in a case-control setting. IgA and IgG antibodies to BSA and ovalbumin were measured from sera of 104 patients with newly diagnosed IDDM and of 111 matched controls by enzyme-linked immunosorbent assay. Patients with diabetes had significantly higher levels of IgA antibodies to BSA ( p = 0.003); IgG antibodies also tended to be higher ( p = 0.08). Levels of IgA antibodies to ovalbumin were similar in the patients and controls, but IgG antibodies were higher in controls ( p = 0.02). When antibodies to BSA, β-lactoglobulin, whole cow's milk and islet cell antibodies were studied as risk determinants of IDDM in a multivariate, logistic regression analysis, IgA antibodies to β-lactoglobulin and to cow's milk were independently associated with the risk ( p = 0.037 and 0.048, respectively), while antibodies to BSA were not a significant risk factor. The results question the role of BSA as a cross-reacting antigen with pancreatic β-cell surface proteins in the aetiology of IDDM. 相似文献
118.
119.
Membrane permeability changes associated with DNA gyrase inhibitors in Escherichia coli. 总被引:13,自引:9,他引:4
下载免费PDF全文
![点击此处可从《Antimicrobial agents and chemotherapy》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Inhibition of DNA synthesis in Escherichia coli B/r by a DNA gyrase inhibitor results in cell death after a 50-min lag period. Examination of the cells under phase-contrast and electron microscopes revealed that they appeared to undergo plasmolysis coincident with the onset of cell death. The inhibited cells were also found to become susceptible to low levels of detergent at this time. With a fluorescent membrane probe, the level of membrane permeability was assessed and found to increase concurrently with the decrease in culture viability. Analysis of the cell envelope constituents revealed that, other than a shift in the protein/lipid ratio, the compositions of the cell membranes were unperturbed. 相似文献
120.
Overdrainage of the cerebrospinal fluid (CSF) and collapse of the ventricles, slit ventricles (SLV), can cause clinical symptoms and result in the slit ventricle syndrome (SLVS). The EEG changes and the frequency and type of epilepsy in patients with SLV was analysed from a material of 113 shunt-treated hydrocephalic children. During the follow-up time (mean 8.9 years), 63 patients (56%) had developed SLV. The age at initial shunting was significantly lower (1.2 years) in patients who developed SLV than for those who did not (2.7 years). After initial shunting generalized spike and sharp wave activity (SWA) developed more frequently in patients who developed SLV (81%) than in those who did not (54%). Severe generalized SWA developed almost entirely in patients in the SLV group. This severe generalized SWA disappeared from the EEG in patients after treatment of the SLVS. Epileptic seizures appeared after initial shunting in 44% of patients in the SLV group but in only 6% of the non-SLV group. Treatment of the SLVS decreased the frequency of epilepsy to a level corresponding with the non-SLV group. Repeated EEG evaluation of shunt-treated hydrocephalic children is a valuable aid in follow-up. If EEG abnormality appears after initial shunting, especially SWA, shunt malfunction and overdrainage of the CSF should be suspected. 相似文献