全文获取类型
收费全文 | 6847篇 |
免费 | 217篇 |
国内免费 | 38篇 |
专业分类
耳鼻咽喉 | 240篇 |
儿科学 | 136篇 |
妇产科学 | 296篇 |
基础医学 | 834篇 |
口腔科学 | 49篇 |
临床医学 | 444篇 |
内科学 | 1839篇 |
皮肤病学 | 128篇 |
神经病学 | 605篇 |
特种医学 | 113篇 |
外科学 | 740篇 |
综合类 | 59篇 |
一般理论 | 10篇 |
预防医学 | 337篇 |
眼科学 | 199篇 |
药学 | 675篇 |
中国医学 | 4篇 |
肿瘤学 | 394篇 |
出版年
2023年 | 27篇 |
2022年 | 177篇 |
2021年 | 260篇 |
2020年 | 72篇 |
2019年 | 136篇 |
2018年 | 151篇 |
2017年 | 114篇 |
2016年 | 124篇 |
2015年 | 164篇 |
2014年 | 210篇 |
2013年 | 322篇 |
2012年 | 446篇 |
2011年 | 567篇 |
2010年 | 277篇 |
2009年 | 185篇 |
2008年 | 447篇 |
2007年 | 540篇 |
2006年 | 495篇 |
2005年 | 532篇 |
2004年 | 520篇 |
2003年 | 452篇 |
2002年 | 396篇 |
2001年 | 21篇 |
2000年 | 26篇 |
1999年 | 28篇 |
1998年 | 29篇 |
1997年 | 18篇 |
1996年 | 24篇 |
1995年 | 33篇 |
1994年 | 21篇 |
1993年 | 18篇 |
1992年 | 15篇 |
1991年 | 21篇 |
1990年 | 9篇 |
1989年 | 12篇 |
1988年 | 7篇 |
1987年 | 17篇 |
1986年 | 9篇 |
1985年 | 15篇 |
1984年 | 22篇 |
1983年 | 16篇 |
1982年 | 22篇 |
1981年 | 12篇 |
1980年 | 10篇 |
1979年 | 15篇 |
1978年 | 12篇 |
1977年 | 7篇 |
1976年 | 5篇 |
1974年 | 7篇 |
1973年 | 6篇 |
排序方式: 共有7102条查询结果,搜索用时 15 毫秒
71.
Wróbel Andrzej Doboszewska Urszula Rechberger Ewa Rojek Karol Serefko Anna Poleszak Ewa Skalicka-Woźniak Krystyna Dudka Jarosław Wlaź Piotr 《Naunyn-Schmiedeberg's archives of pharmacology》2017,390(6):613-619
Naunyn-Schmiedeberg's Archives of Pharmacology - Hemorrhagic cystitis often develops in patients treated with cyclophosphamide (CYP). Studies have indicated that Rho kinase (ROCK) inhibitors... 相似文献
72.
73.
74.
75.
Magdalena Groblewska Barbara Mroczko Mariusz Gryko Anna Pryczynicz Katarzyna Guzińska-Ustymowicz Bogusław Kędra Andrzej Kemona Maciej Szmitkowski 《Tumour biology》2014,35(4):3793-3802
The objective of the study was the assessment of serum levels and tissue expression of matrix metalloproteinase 2 (MMP-2) and tissue inhibitor of matrix metalloproteinases 2 (TIMP-2) in patients with colorectal cancer (CRC). The study included 72 CRC patients and 68 healthy subjects. The serum levels of MMP-2 and TIMP-2 were measured using enzyme-linked immunosorbent assay (ELISA) method, whereas tissue expression of MMP-2 and TIMP-2 in cancer cells, interstitial inflammatory cells, and adjacent normal colorectal mucosa were examined by immunohistochemical staining of tumor samples. The serum levels of MMP-2 and TIMP-2 in cancer patients were significantly lower than those in control group, but the percentage of positive immunoreactivity of these proteins were higher in malignant and inflammatory cells as compared to normal tissue. There was a significant correlation between MMP-2 immunoreactivity in inflammatory cells and the presence of distant metastases and between TIMP-2 expression in inflammatory cells and tumor size, nodal involvement, and distant metastases. Area under receiver operating characteristic (ROC) curve (AUC) for serum MMP-2 was higher than for serum TIMP-2. Moreover, positive tissue expression of MMP-2 was a significant prognostic factor for CRC patients’ survival. Our findings suggest that MMP-2 and TIMP-2 might play a role in the process of colorectal cancer invasion and metastasis, but the significance of their interactions with tumor stroma and interstitial inflammatory infiltration in colorectal neoplasia require further elucidation. 相似文献
76.
77.
Staphylococcus aureus is a common and often virulent pathogen in humans. This bacterium is widespread, being present on the skin and in the nose of healthy people. Staphylococcus aureus can cause infections with severe outcomes ranging from pustules to sepsis and death. The introduction of antibiotics led to a general belief that the problem of bacterial infections would be solved. Nonetheless, pathogens including staphylococci have evolved mechanisms of drug resistance. Among current attempts to address this problem, phage therapy offers a promising alternative to combat staphylococcal infections. Here, we present an overview of current knowledge on staphylococcal infections and bacteriophages able to kill Staphylococcus, including experimental studies and available data on their clinical use. 相似文献
78.
79.
80.