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141.
Yashashwi Pokharel Farah Mouhanna Andrea L. C. Schneider Andreea M. Rawlings David S. Knopman Vijay Nambi Salim S. Virani Ron C. Hoogeveen Alvaro Alonso Gerardo Heiss Josef Coresh Thomas Mosley Rebecca Gottesman Elizabeth Selvin Christie Ballantyne Melinda C. Power 《Journal of the American Geriatrics Society》2019,67(11):2353-2361
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Carina Ureche Radu Sascu Laura
poi Andreea Covic Corneliu Moroanu Luminia Voroneanu Alexandru Burlacu Cristian Sttescu Adrian Covic 《Echocardiography (Mount Kisco, N.Y.)》2019,36(7):1372-1380
Cardiovascular disease (CVD) is the leading cause of death worldwide and is particularly frequent among those with severe renal impairment. Early diagnosis and therapeutic intervention may help alleviate the burden of cardiovascular complication within this population. In the last years, advances have been made toward developing noninvasive imaging techniques that could offer better insight into the cardiac involvement in end‐stage renal disease (ESRD). Conventional transthoracic echocardiography remains the first‐line investigation used to assess cardiac function, but encompassing in our daily practice, the newer approaches such as speckle‐tracking imaging, cardiac computed tomography, or cardiac magnetic resonance can guide us to a more comprehensive understanding of CVD in ESRD. Given that patients with chronic kidney disease may not present with typical CVD symptoms, the amount of information brought by newer imaging techniques is crucial for an accurate diagnosis, risk stratification, and further management. The purpose of this review is to briefly summarize the specific applications of standard cardiac imaging techniques in patients with ESRD and to offer insight into the novel imaging modalities, highlighting the newest research in this field. By doing so, we aim to identify the most important imaging predictors of clinical outcomes in this population. 相似文献
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Sonia Vanderby Andreea Badea Juan Nicolás Peña Sánchez Neil Kalra Paul Babyn 《Journal l'Association canadienne des radiologistes》2018,69(2):151-161
Purpose
This study aimed to determine the volumes and types of magnetic resonance imaging exams being performed across Canada, common indications for the exams, and exam appropriateness using multiple evaluation tools.Methods
Thirteen academic medical institutions across Canada participated. Data were obtained relating to a single common day, October 1, 2014. Patient demographics, type by anatomic region and indication for imaging were analysed. Each exam was assessed for appropriateness via the Canadian Association of Radiologists Referral Guidelines and the American College of Radiology Appropriateness Criteria. The Alberta and Saskatchewan spine screening forms and the Alberta knee screening form were also used where applicable. The proportion of exams that were unscorable, appropriate, and inappropriate was determined. Exam-level results were compared between the 2 main evaluation tools.Results
Data were obtained for 1087 relevant exams. There were 591 women and 460 men. 36 requisitions did not indicate the patient's sex. Brain exams were the most common, comprising 32.5% of the sample. Cancer was the most common indication. Overall, 87.0%–87.4% of the MR exams performed were appropriate; 6.6%–12.6% were inappropriate, based on the 2 main evaluation tools. Results differed by anatomic region; spine exams had the highest proportion, with nearly one-third of exams deemed inappropriate.Conclusion
Variations by anatomic region indicate that focused exam request evaluation or screening methods could substantially reduce inappropriate imaging. 相似文献145.
Neuroblastoma among children in Southern and Eastern European cancer registries: Variations in incidence and temporal trends compared to US 下载免费PDF全文
Marios K. Georgakis Nick Dessypris Margarita Baka Maria Moschovi Vassilios Papadakis Sophia Polychronopoulou Maria Kourti Emmanuel Hatzipantelis Eftichia Stiakaki Helen Dana Evdoxia Bouka Luis Antunes Joana Bastos Daniela Coza Anna Demetriou Domenic Agius Sultan Eser Raluca Gheorghiu Mario Sekerija Maciej Trojanowski Tina Zagar Anna Zborovskaya Anton Ryzhov Athanassios Tragiannidis Paraskevi Panagopoulou Eva Steliarova‐Foucher Eleni Th. Petridou 《International journal of cancer. Journal international du cancer》2018,142(10):1977-1985
Neuroblastoma comprises the most common neoplasm during infancy (first year of life). Our study describes incidence of neuroblastoma in Southern–Eastern Europe (SEE), including – for the first time – the Nationwide Registry for Childhood Hematological Malignancies and Solid Tumors (NARECHEM‐ST)/Greece, compared to the US population, while controlling for human development index (HDI). Age‐adjusted incidence rates (AIR) were calculated for 1,859 childhood (0–14 years) neuroblastoma cases, retrieved from 13 collaborating SEE registries (1990–2016), and were compared to those of SEER/US (N = 3,166; 1990–2012); temporal trends were assessed using Poisson regression and Joinpoint analyses. The overall AIR was significantly lower in SEE (10.1/million) compared to SEER (11.7 per million); the difference was maximum during infancy (43.7 vs. 53.3 per million, respectively), when approximately one‐third of cases were diagnosed. Incidence rates of neuroblastoma at ages <1 and 1–4 years were positively associated with HDI, whereas lower median age at diagnosis was correlated with higher overall AIR. Distribution of primary site and histology was similar in SEE and SEER. Neuroblastoma was slightly more common among males compared to females (male‐to‐female ratio: 1.1), mainly among SEE infants. Incidence trends decreased in infants in Slovenia, Cyprus and SEER and increased in Ukraine and Belarus. The lower incidence in SEE compared to SEER, especially in infants living in low HDI countries possibly indicates a lower level of overdiagnosis in SEE. Hence, increases in incidence rates in infancy noted in some subpopulations should be carefully monitored to avoid the unnecessary costs health impacts of tumors that could potentially spontaneously regress. 相似文献
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149.
Yasser Salama Saleh Albanyan Marta Szybowska Garrett Bullivant Bailey Gallinger Rachel H. Giles Sylvia Asa Chansonette Badduke Andreea Chiorean Harriet Druker Shereen Ezzat Fady Hannah-Shmouni Karen G. Hernandez Cara Inglese Payal Jani Yuvreet Kaur Hatem Krema Lior Krimus Normand Laperriere Zsuzanna Lichner Ozgur Mete Marisa Sit Gelareh Zadeh Michael A.S. Jewett David Malkin Tracy Stockley Jonathan D. Wasserman Wei Xu Nathan F. Schachter Raymond H. Kim 《Clinical genetics》2019,96(5):461-467
Von Hippel-Lindau disease (VHL) is a heritable condition caused by pathogenic variants in VHL and is characterized by benign and malignant lesions in the central nervous system (CNS) and abdominal viscera. Due to its variable expressivity, existing efforts to collate VHL patient data do not adequately capture all VHL manifestations. We developed a comprehensive and standardized VHL database in the web-based application, REDCap, that thoroughly captures all VHL manifestation data. As an initial trial, information from 86 VHL patients from the University Health Network/Hospital for Sick Children was populated into the database. Analysis of this cohort showed missense variants occurring with the greatest frequency, with all variants localizing to the α- or β-domains of VHL. The most prevalent manifestations were central nervous system (CNS), renal, and retinal neoplasms, which were associated with frameshift variants and large deletions. We observed greater age-related penetrance for CNS hemangioblastomas with truncating variants compared to missense, while the reverse was true for pheochromocytomas. We demonstrate the utility of a comprehensive VHL database, which supports the standardized collection of clinical and genetic data specific to this patient population. Importantly, we expect that its web-based design will facilitate broader international collaboration and lead to a better understanding of VHL. 相似文献