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Aleksandrova IuN Lyshchëv AA Safronnikova NR Rudenko VI Imianitov EN Khnason KP 《Voprosy onkologii》2000,46(2):175-179
The study was aimed to evaluate the features of human papillomavirus (HPV) infection in healthy female inhabitants of St. Petersburg. 309 attendants of gynecological clinics were recruited for the screening. All participants were of reproductive age and were lacking the clinical or morphological symptoms of HPV-related diseases. PCR revealed HPV-specific sequences in 90 (29%) women. HPV type distribution was similar to the one in USA and Europe. HPV-positivity did not correlate with age of females, age at sexual debut, or total life-long duration of sexual activity. However, HPV were overrepresented among women reporting excessive number of contraceptive abortions. The data imply that an establishment of large-scale HPV-testing in Russia could be a desirable component of preventive anti-cancer programs. 相似文献
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Voutsadakis IA 《Medical oncology (Northwood, London, England)》2000,17(4):249-257
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Examination of blood rheologic properties in 38 patients with chronic ++post-embolic pulmonary hypertension revealed an elevated blood viscosity at all shift rates and a reduced erythrocyte deformability. A close positive correlation was found between blood viscosity and perfusion deficit. Hemorheologic disorders in patients with chronic post-embolic + pulmonary hypertension are caused by pachyhemia and blood acid-base imbalance due to respiratory failure. They deteriorate pulmonary and systemic hemodynamic disturbances and contribute to progression of blood flow derangement. 相似文献
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本文观察了大鼠实验性急性胰腺炎时血浆和组织脂质过氧化物(LPO)的动态变化。发病后10h动物血浆LPO即见升高,而血浆淀粉酶水平则开始下降。发病10、20h心、肝、肾、肺组织LPO也有不同程度的升高。这证实了氧自由基在急性胰腺炎病理过程中起一定作用。与用血清淀粉酶水平判断急性胰腺炎的发生、发展这一传统方法相比,血浆LPO更能反映急性胰腺炎后期病变的程度及此时全身器官组织受损的情况。 相似文献
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The effect of amplifying reproduction of influenza virus in mouse lungs during simultaneous infection with two cold-adapted strains 总被引:1,自引:0,他引:1
Iu R Romanov A Iu Egorov K V Lisovskaia T E Medvedeva G N Nevedomskaia G I Aleksandrova A I Klimov 《Voprosy virusologii》1989,34(5):547-553
Reproduction of cold-adapted (ca) strains of influenza virus in the lungs of white mice after separate and combined inoculation and the properties of isolates derived from the infected animals were studied. It was shown that after combined inoculation with ca and ts strains A/Leningrad/134/17/57 (H2N2) and A/PR/8/59/1 (H1N1) ca recombinants could develop loosing some ts mutations and possessing (unlike the master strains) pneumo-virulence for mice. All the pneumo-virulent reassortants inherited hemagglutinin from the ca A/PR/8/59/1 strain and PB1 protein from the ca A/Leningrad/134/17/57 strain. The results indicate that it is unsafe to construct live recombinant divaccines by combining the recombinants produced from different donors of attenuation. 相似文献
58.
The interfering activity of influenza virus variants A/Hong Kong/1/68 (H3N202), A/Victoria/35/72(H3N2-3), B/14/55 and B/USSR/69 differing in the level of their reactogenicity for adults and children was studied. An inverse relationship was established between reactogenicity of the strains and their interfering activity in the resistant chick embryo cell (CEC) cultures. Virulent strains did not interfere with vesicular stomatitis virus. Vaccine strains used for commercial live influenza vaccine safe for adults but reactogenic in children were intermediate and showed moderate interfering activity. The highest capacity for interference was demonstrated in cold-adapted thermosensitive variants non-pathogenic for both adults and children. The interfering activity of the attenuated strains increased progressively with increasing inocula. 相似文献
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Determination by the radioimmunological method of thyrotropic hormone (TTH), thyroxin and triiodothyronine in the blood serum of patients with Itsenko-Cushing's disease showed thyroxin level to decrease depending on the duration of the disease and the severity of the clinical course of the disease. Triiodothyronine content rose against the background of the elevated TTH content, this indicating the presence of latent hypothyroidism in these patients; one of the causes of the latter can be changed in thyroxin metabolism with the formation of a less active form of triiodothyronine. 相似文献