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151.
Echocardiographic predictors of outcome in patients with chronic obstructive pulmonary disease
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![点击此处可从《Journal of clinical ultrasound : JCU》网站下载免费的PDF全文](/ch/ext_images/free.gif)
152.
Jeremic B Milicic B Grujicic D Dagovic A Aleksandrovic J 《Journal of cancer research and clinical oncology》2003,129(8):477-484
We investigated the influence of various clinical prognostic factors in patients with glioblastoma multiforme (GBM) treated with a combined modality approach. A total of 175 patients with GBM was treated in four consecutive prospective phase II studies using surgery, hyperfractionated or accelerated hyperfractionated radiotherapy (RT) and either adjuvant or concurrent or pre-irradiation chemotherapy (CHT) between January 1988 and December 1993. The median survival time for all 175 patients was 14 months and 1-3-year survival (OS) rates were 57%, 34% and 24%, respectively. The median time to tumour progression was 12 months, and 1-3-year progression-free survival (PFS) rates were 43%, 11% and 7%, respectively. Survival analysis showed that of all investigated prognostic factors, only gender did not influence survival. Patients =55 years did better than those >55 years; patients with KPS 80-100 did better than those with KPS 50-70; patients with frontal tumours did better than those with tumours in other locations; patients with tumours up to 4 cm did better than those with larger tumours, as did patients with either subtotal or gross total tumour resection when compared to those undergoing biopsy only. Multivariate analysis showed that gender and tumour location did not independently influence survival. When PFS was used as the endpoint, only gender did not influence PFS, as confirmed by multivariate analysis. 相似文献
153.
154.
Familial deletion of the HOXA gene cluster associated with Hand–Foot–Genital syndrome and phenotypic variability
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155.
Beyond Down syndrome phenotype: Paternally derived isodicentric chromosome 21 with partial monosomy 21q22.3
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156.
Jelena Karanović Saša Šviković Maja Pantović Svetlana Durica Goran Brajušković Aleksandar Damjanović 《The world journal of biological psychiatry》2015,16(4):261-271
Objectives. Adenosine to inosine RNA editing, serotonin 2C receptor (HTR2C), and stressful life events (SLEs) have all been implicated in suicidal behaviour. We examined the main and moderating effects of RNA editing (ADAR, ADARB1) and HTR2C genes, childhood trauma (CT), recent SLEs and psychiatric disorders as contributors to suicide attempt (SA) vulnerability. Methods. Study included 165 suicide attempters and 188 suicide non-attempters, all diagnosed with one of major psychiatric disorders. CT and recent SLEs were assessed using Early Trauma Inventory–Self Report and List of Threatening Experiences Questionnaire, respectively. Selected ADAR and ADARB1 tag-variants, and HTR2C rs6318 were pre-screened for association with SA, while generalized linear models and backward selection were applied to identify individual and interacting SA risk factors. Results. ADARB1 rs9983925 and rs4819035 and HTR2C rs6318 were associated with SA. The best minimal model found emotional abuse, recent SLEs, rs9983925 and rs6318 as independent SA risk factors, and general traumas as a factor moderating the effect of psychiatric disorders and emotional abuse. Conclusions. SA vulnerability in psychiatric patients is related to the joint effect of ADARB1 and HTR2C variants, the existing mood disorder and the cumulative exposures to a various childhood and recent stressful experiences. 相似文献
157.
Croatia has a low-level HIV epidemic and, as in a number of other Central and Southeastern European countries, sex between
men accounts for most HIV infections. This study examines sexual behavior and the correlates of condom use in a snowball sample
of 342 HIV non-infected men who have sex with men (MSM) in Zagreb. The median age of participants in the sample was 27 years.
The majority of participants (81%) reported using condom at last anal sex with casual partner and 56% claimed to have used
condoms consistently at anal sex with casual partners in the last 12 months. HIV risk self-assessment and number of sexual
partners were significantly correlated with condom use at last anal sex with casual partner. Self-assessed HIV-risk and heterosexual
activity were found associated with consistent condom use at anal sex with casual partners. To sustain a low-level HIV epidemic,
targeted intervention among young MSM is needed in Croatia. 相似文献
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