全文获取类型
收费全文 | 9534篇 |
免费 | 593篇 |
国内免费 | 49篇 |
专业分类
耳鼻咽喉 | 90篇 |
儿科学 | 268篇 |
妇产科学 | 159篇 |
基础医学 | 1343篇 |
口腔科学 | 234篇 |
临床医学 | 637篇 |
内科学 | 2451篇 |
皮肤病学 | 374篇 |
神经病学 | 727篇 |
特种医学 | 435篇 |
外科学 | 849篇 |
综合类 | 54篇 |
一般理论 | 1篇 |
预防医学 | 547篇 |
眼科学 | 211篇 |
药学 | 695篇 |
中国医学 | 44篇 |
肿瘤学 | 1057篇 |
出版年
2023年 | 58篇 |
2022年 | 111篇 |
2021年 | 250篇 |
2020年 | 150篇 |
2019年 | 209篇 |
2018年 | 261篇 |
2017年 | 237篇 |
2016年 | 257篇 |
2015年 | 235篇 |
2014年 | 368篇 |
2013年 | 411篇 |
2012年 | 599篇 |
2011年 | 698篇 |
2010年 | 411篇 |
2009年 | 393篇 |
2008年 | 527篇 |
2007年 | 625篇 |
2006年 | 569篇 |
2005年 | 591篇 |
2004年 | 589篇 |
2003年 | 534篇 |
2002年 | 475篇 |
2001年 | 142篇 |
2000年 | 111篇 |
1999年 | 129篇 |
1998年 | 93篇 |
1997年 | 72篇 |
1996年 | 71篇 |
1995年 | 43篇 |
1994年 | 37篇 |
1993年 | 39篇 |
1992年 | 75篇 |
1991年 | 101篇 |
1990年 | 81篇 |
1989年 | 74篇 |
1988年 | 64篇 |
1987年 | 69篇 |
1986年 | 63篇 |
1985年 | 61篇 |
1984年 | 46篇 |
1983年 | 30篇 |
1982年 | 14篇 |
1981年 | 21篇 |
1980年 | 16篇 |
1979年 | 20篇 |
1978年 | 21篇 |
1977年 | 14篇 |
1974年 | 12篇 |
1973年 | 13篇 |
1972年 | 14篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
51.
52.
Ohara-Nemoto Y Kishi K Satho M Tajika S Sasaki M Namioka A Kimura S 《Journal of clinical microbiology》2005,43(3):1405-1407
We studied the pheno- and genotypes of an oral Granulicatella elegans strain in comparison with those of a blood-derived isolate which caused infective endocarditis. The two isolates exhibited identical biochemical characteristics and had the same drug MICs. Their genotypes were indistinguishable, indicating that these were from the same clone. The transmission of G. elegans from the oral cavity thus should be noted as a possible cause of infective endocarditis. 相似文献
53.
Shigesaburo Miyakoshi Eiji Kusumi Tomoko Matsumura Akiko Hori Naoko Murashige Tamae Hamaki Koichiro Yuji Naoyuki Uchida Kazuhiro Masuoka Atsushi Wake Yoshinobu Kanda Masahiro Kami Yuji Tanaka Shuichi Taniguchi 《Biology of blood and marrow transplantation》2007,13(7):771-777
Invasive fungal infection (IFI) is a significant complication after allogeneic hematopoietic stem cell transplantation (HSCT); however, we have little information on its clinical features after reduced intensity cord blood transplantation (RICBT) for adults. We reviewed medical records of 128 patients who underwent RICBT at Toranomon Hospital between March 2002 and November 2005. Most of the patients received purine-analogbased preparative regimens. Graft-versus-host disease (GVHD) prophylaxis was a continuous infusion of either tacrolimus 0.03 mg/kg or cyclosporine 3 mg/kg. IFI was diagnosed according to the established EORTC/NIH-MSG criteria. IFI was diagnosed in 14 patients. Thirteen of the 14 had probable invasive pulmonary aspergillosis and the other had fungemia resulting from Trichosporon spp. Median onset of IFI was day 20 (range: 1-82), and no patients developed IFI after day 100. Three-year cumulative incidence of IA was 10.2%. Four of the 13 patients with invasive aspergillosis (IA) developed grade II-IV acute GVHD, and their IA was diagnosed before the onset of acute GVHD. The mortality rate of IFI was 86%. Multivariate analysis revealed that the use of prednisolone >0.2 mg/kg (relative risk 7.97, 95% confidence interval 2.24-28.4, P = .0014) was a significant risk factor for IA. This study suggests that IFI is an important cause of deaths after RICBT, and effective strategies are warranted to prevent IFI. 相似文献
54.
55.
Uehara S Tamura M Nata M Ji G Yaegashi N Okamura K Yajima A 《Journal of human genetics》2000,45(3):119-126
56.
PCR analysis of the Y chromosome long arm in azoospermic patients: evidence for a second locus required for spermatogenesis 总被引:20,自引:2,他引:20
Kobayashi Kazuhiro; Mlzuno Kunihiko; Hida Akiko; Komakl Rie; Tomita Keiko; Matsushita Ikumi; Namlki Mikio; Iwamoto Teruaki; Tamura Shohzoh; Minowada Shlgeru; Nakahori Yutaka 《Human molecular genetics》1994,3(11):1965-1967
We analyzed DNA from 63 Japanese men with either azoospermiaor severe oligospermia whose Y chromosomes were cytogeneticallynormal. A total of 16 loci were examined: 15 loci on the longarm between DYS7E and DYZ1, and the YRRM1 locus, a candidategene for the azoospermic factor, AZF. One patient with a perlcentricinversion of the Y chromosome was also included. We detectedmicro-deletions in ten individuals. The YRRM1 gene was Involvedin only three of them. The remaining seven patients showed deletionbetween DYS7C and DYS239 in common, indicating the presenceof at least one additional gene, deletion of which causes azoospermia. 相似文献
57.
Pathogenesis of Rinderpest Virus Infection in Rabbits II. Effect of Rinderpest Virus on the Immune Functions of Rabbits 下载免费PDF全文
Kazuya Yamanouchi Akiko Fukuda Fumio Kobune Yasuhiro Yoshikawa Fumitoshi Chino 《Infection and immunity》1974,9(2):206-211
Rinderpest virus infection was shown to induce marked suppression of both humoral antibody response and cell-mediated immunity in rabbits. The virus exhibited a suppressive effect on primary antibody response as indicated by a decrease in numbers of plaque-forming cells (immunoglobulin [Ig]M) and hemagglutinating antibody titers of both IgM and IgG types to sheep red blood cells, whereas there was no detectable effect of the virus on the production of memory cells. Virus-induced suppression of cell-mediated immunity was demonstrated by a decreased rate of proliferative response of peripheral lymphocytes to phytohemagglutinin stimulus and by a depression of delayed-type skin reactions to purified protein derivative. Such suppressive effects were indicated to persist for 14 days or longer. Alteration in phagocytic activity of the reticuloendothelial system was not observed. The relevance of the virus-induced histological lesions in the lymphoid tissues to the virus-induced immunosuppression was discussed. 相似文献
58.
Keisuke Izumi Hisashi Otsuka Keizo Furuya Akiko Akagi 《Virchows Archiv : an international journal of pathology》1979,384(3):263-267
Summary The carcinogenicity of 1,2-dimethylhydrazine dihydrochloride (DMH) by oral, intragastric and subcutaneous administration was examined in 339 BALB/c mice. Subcutaneous injection of DMH induced intestinal tumors in the lower colon of all mice. After oral administration it induced a high incidence of vascular tumors in the liver and soft tissues, but colon tumors were found in only 2 mice when given at a high dosage. On intragastric administration, it induced a fairly high incidence both of colon and vascular tumors. The sites and incidences of vascular tumors and squamous cell carcinomas of the perianal glands were also described.This work was supported in part by a Grant-in Aid for Cancer Research from the Ministry of Education, Japan. 相似文献
59.
Ota H Hayama M Nakayama J Hidaka H Honda T Ishii K Fukushima M Uehara T Kurihara M Ishihara K Hotta K Katsuyama T 《American journal of clinical pathology》2001,115(1):69-79
The specificity of monoclonal antibodies against gastric mucins (designated as HIK1083, PGM 36, and PGM 37) was studied immunohistochemically in normal, metaplastic, and neoplastic human tissues. These antibodies labeled class III mucin-producing cells identified by paradoxical concanavalin A staining in normal stomach, duodenum (Brunner gland), biliary tract, and main pancreatic duct; in mucinous metaplasia of pancreas and gallbladder; and in adenocarcinomas of stomach (90%), bile duct (80%), gallbladder (100%), pancreas (80%), lung (100% of goblet cell type adenocarcinomas), ovary (67% of mucinous carcinomas), and uterine cervix (100% of adenoma malignum tumors). Normal and neoplastic cells of esophagus, colon, salivary gland, kidney, endometrium, breast, prostate, and liver, as well as normal small intestine, lung, and uterine cervix, were all negative. The antibodies used should be valuable for the detection of class III mucin and class III mucin-producing cells in normal, metaplastic, and neoplastic tissues. 相似文献
60.
Shibahara H Tsunoda T Taneichi A Hirano Y Ohno A Takamizawa S Yamaguchi C Tsunoda H Sato I 《American journal of reproductive immunology (New York, N.Y. : 1989)》2002,47(3):146-150
PROBLEM: The presence of antisperm antibodies (ASA) in males can reduce fecundity, however, relationship between the two is disputed. This study was performed to investigate if there is diversity of ASA bound to sperm surface using immunobead test (IBT) combined with complement dependent sperm immobilization test (SIT). METHODS: The ASA bound to sperm surface were detected using the direct IBT (D-IBT) in 275 semen samples. In some cases with ASA detected by D-IBT, sperm immobilizing antibodies bound to sperm surface were also evaluated using direct SIT (D-SIT). RESULTS: The incidence of the immunoglobulin G (IgG), IgA, and IgM classes of ASA detected by D-IBT were 2.5, 1.8, and 0.4%, respectively. Totally, nine (3.3%) infertile men had ASA on the sperm surface. D-SIT was tested positive in four (66.7%) of six cases with ASA assessed by D-IBT. CONCLUSIONS: Some of the sperm-bound antibodies are associated with complement dependent sperm immobilizing antibodies, indicating that there exists a heterogeneity of sperm-bound antibodies. This result might be one of the reasons for the controversy about the relationship between ASA and immunological infertility in men. 相似文献