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排序方式: 共有418条查询结果,搜索用时 0 毫秒
41.
42.
B B Hayes A Afshari L Millecchia P A Willard S P Povoski B J Meade 《Toxicological sciences》2000,56(2):262-270
Latex allergy is recognized worldwide as a serious health risk. To date, exposure assessment and intervention strategies have focused primarily on respiratory protection; this work evaluates the potential role of dermal protein penetration in the development of latex allergy. In vitro penetration models using flow-through diffusion cells and both human surgical specimens and hairless guinea pig skin (CrL: IAF/HA) demonstrated iodinated latex proteins (ammoniated and non-ammoniated) penetrating into and through both intact and abraded skin. Although less than 1% penetration was observed with intact skin, up to 23% of latex proteins applied to abraded skin were recovered from receptor fluid within 24 h of exposure. Phosphoimaging of the concentrated effluent revealed proteins ranging in size from 3 to 26 kDa. Using a (3)H(2)O penetration assay to evaluate barrier integrity, the amount of latex protein penetration was found to positively correlate with the degree of dermabrasion. Immunohistochemistry of the skin localized latex proteins in the Langerhans cell-rich epidermis and in the dermis. Both in vitro penetration studies and immunohistochemistry supported the use of hairless guinea pig skin as a surrogate for human skin in evaluating latex protein penetration. In studies performed in vivo, 35% of hairless guinea pigs topically exposed to latex proteins (100 microg) 5 days per week for 3 months demonstrated elevations in latex-specific IgG1. The implication for these data is that the skin is not only a plausible route for latex sensitization but can be a major exposure route when the integument has been compromised. 相似文献
43.
C. Boulanger NA Flavahan ZS Katusic K. Komori AA Vos and PM Vanhoutte MD Director 《Fundamental & clinical pharmacology》1990,4(5):525-538
Experiments were designed to determine the effect of CRL 41034, a buflomedil analogue, on the adrenergic responsiveness of canine veins. Rings of saphenous vein (without endothelium) were suspended for isometric tension recording in modified Krebs-Ringer bicarbonate solution at 37 degrees C. CRL 41034 produced a concentration-dependent inhibition of the contractions evoked by the alpha adrenergic agonists norepinephrine, phenylephrine and UK 14304 which was insensitive to the blockade of neuronal uptake by cocaine. CRL 41034 was more potent in inhibiting the concentration-dependent contractions evoked by UK 14304 than those by phenylephrine and the antagonism it caused against the response to UK 14304 fulfilled the criteria for competitivity. CRL 41034, at 10(-5) M significantly depressed, and at 10(-4) M abolished the contractions induced by electrical stimulation of the adrenergic nerves and those evoked by the indirect sympathomimetic amine tyramine. Strips of canine saphenous vein were superfused after incubation with [3H] norepinephrine. During sympathetic nerve activation, CRL 41304 increased the stimulation-evoked overflow of [3H] norepinephrine and 3-methoxy-4-dihydroxyphenylglycol; in the presence of rauwolscine the compound only increased the stimulation-evoked overflow of 3,4-dihydroxyphenylglycol. These experiments suggest that the major vascular effects of CRL 41034 in canine veins are blockade of alpha 2-adrenoceptors on vascular smooth muscle, and inhibition of prejunctional alpha 2-adrenoceptors on adrenergic nerve endings. 相似文献
44.
Dr. ZS Meharwal A Choudhary N Trehan 《Indian Journal of Thoracic and Cardiovascular Surgery》2002,18(2):75-79
Background. Use of intra-aortic balloon pump (IABP) is associated with certain vascular complications, which are likely to develop more
frequently in patients where IABP is used for prolonged period. The present study was undertaken to analyze vascular complications
after prolonged IABP use in patients undergoing various cardiac surgical procedures.
Methods. Between January 1995 and February 2001, a total of 1130 patients (7.4% of all adult patients undergoing cardiac procedures)
required IABP counterpulsation, out of which 220 patients required IABP for more than 4 days. The vascular complications in
these patients were studied. The IABP was inserted by percutaneous technique in 211 (95.5%) patients. The mean age of the
patients was 57.5±9.5 years and 15% patients were female. The prevalence of peripheral vascular disease was 11.8%.
Results. The duration of IABP therapy ranged from 5 days to 21 days with mean duration of 9.71±4.29 days. A total of 41 complications
developed in 38 (17.3%) patients. Acute lower limb ischemia, requiring urgent surgical intervention, was the commonest major
complication, which developed in 17 patients. This required thromboembolectomy in 11 patients and femoro-femoral bypass in
3 patients. One patient developed gangrene of the leg, requiring below knee amputation. On multivariate analysis, peripheral
vascular disease, preoperative serum creatinine, surgery for LV aneurysm and unstable angina and hemodynamic instability (as
the indications for IABP) were found as the predictors of vascular complications.
Conclusions. Prolonged use of IABP counterpulsation is associated with significant incidence of vascular complications. Proper assessment
of peripheral circulation before IABP insertion and appropriate management of ischemic complications are important to avoid
limb loss to the patient. 相似文献
45.
46.
Judy Chia-Chun Yuan Valentim Adelino Ricardo Barão Alvin G. Wee Maria F. Alfaro Fatemeh S. Afshari Cortino Sukotjo 《The Journal of prosthetic dentistry》2018,119(6):1000-1006
Statement of problem
The effects of toothbrushing (B) and thermocycling (TC) on the surface texture of different materials with various fabrication processes have been investigated. However, studies of computer-aided design and computer-aided manufacturing (CAD-CAM) ceramic restorations are limited.Purpose
The purpose of this in vitro study was to evaluate the effect of B and TC on the color stability and surface roughness of extrinsically characterized and glazed CAD-CAM ceramic restorations.Material and methods
Lithium disilicate CAD ceramic (n=90) and zirconia ceramic (n=90) were studied. All specimens were crystallized/sintered, characterized, and glazed following the manufacturer’s recommendation. The specimens were divided into 9 different groups: B, TC, and a combination of B plus TC (B+TC). Brushing was performed at 50?000, 100?000, and 150?000 cycles, simulating an oral environment of 5, 10, and 15 years. Thermocycling was performed at 6000, 12?000, and 18?000 cycles, simulating an oral environment of 5, 10, and 15 years. Brushing plus TC was performed with the combination of the 50?000 cycles of B, then 6000 cycles of TC, and 10?000 cycles of B, then 12?000 cycles of TC, and 15?000 cycles of B, then 18?000 cycles of TC. The color and surface roughness of each specimen were measured before and after all interventions with simulated cycles. Color differences (ΔE) and surface roughness (ΔRa) data were analyzed using 2-way ANOVA, followed by the least significant difference test (α=.05). The correlation between ΔE and ΔRa was statistically analyzed using the Pearson correlation analysis.Results
Within the lithium disilicate CAD groups, intervention did not result in any significant differences in color change (P>.05). Within the zirconia groups, a 15-year clinical simulation revealed significantly higher ΔE values than a simulated 5-year exposure (P=.017). Increased simulated cycles showed significantly higher Ra values for all groups. Within the zirconia groups, B revealed significantly smoother surfaces than TC (P<.001) and B+TC interventions (P<.001). For the zirconia, simulating B+TC for15 years revealed significantly higher Ra values than the groups of B+TC for 5 years (P<.001) and B+TC for 10 years (P=.003). No correlation (lithium disilicate CAD, r=.079; P=.462; zirconia, r=.001; P=.989) was found between the color change and surface roughness.Conclusions
For both lithium disilicate CAD and zirconia, color changes were below the selected clinical perceptible threshold (ΔE=2.6) after all intervention and simulated cycles. All mean surface roughness measurements were below 0.2 μm. Generally, the surface of both lithium disilicate CAD and zirconia became rougher. No correlation was found between color difference and surface roughness for either material. 相似文献47.
48.
Afshari NA Gorovoy MS Yoo SH Kim T Carlson AN Rosenwasser GO Griffin NB McCuen BW Toth CA Price FW Price M Fernandez MM 《American journal of ophthalmology》2012,153(4):638-42, 642.e1-2
49.
50.
Ocular inflammation occurs in many patients with systemic rheumatic disease. The best examples are rheumatoid arthritis, juvenile rheumatoid arthritis, temporal arteritis, systemic lupus erythematosus, Wegener’s granulomatosis, polyarteritis nodosa, relapsing polychondritis, and Adamantiades-BehÇet’s disease. Ocular inflammation may precede the symptoms of the systemic disease and can be helpful in systemic diagnosis. After diagnosis, ocular inflammation can mark the severity of the systemic condition. Thus, prompt diagnosis and treatment of inflammatory conditions of the eye are warranted and may be sight- and life-saving. 相似文献