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991.
Rammelt S Neumann M Hanisch U Reinstorf A Pompe W Zwipp H Biewener A 《Journal of biomedical materials research. Part A》2005,73(3):284-294
The effect of osteocalcin (OC), an extracellular bone matrix protein, on bone healing around hydroxyapatite/collagen composites was investigated. Cylindrical nanocrystalline hydroxyapatite implants of 2.5-mm diameter containing 2.5% biomimetically mineralized collagen type I were inserted press-fit into the tibial head of adult Wistar rats. To one implant group, 10 mug/g OC was added. Six specimens per group were analyzed at 2, 7, 14, 28, and 56 days. After 14 days, newly formed woven bone had reached the implant surface of the OC implants whereas a broad fibrous interface could still be observed around controls. Woven bone was formed directly around both implant groups after 28 days and had been replaced partially by lamellar bone around the OC implants only. No significant differences in total bone contact were seen between both groups after 56 days. The higher number of phagocytosing cells and osteoclasts characterized immunohistochemically with ED1, cathepsin D, and tartate-resistant alkaline phosphatase around the OC implants at the early stages of bone healing suggests an earlier onset of bone remodeling. The earlier and increased expression of bone-specific matrix proteins and multifunctional adhesion proteins (osteopontin, bone sialoprotein, CD44) at the interface around the OC implants indicates that OC may accelerate bone formation and regeneration. This study supports the observations from in vitro studies that OC activates both osteoclasts and osteoblasts during early bone formation. 相似文献
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Gauchel Nadine Rieder Marina Krauel Krystin Goller Isabella Jeserich Maren Salzer Ulrich Venhoff Ana Cecilia Baldus Niklas Pollmeier Luisa Wirth Luisa Kern Winfried Rieg Siegbert Busch Hans-Jörg Hofmann Maike Bode Christoph Duerschmied Daniel Lother Achim Heger Lukas A. 《Journal of thrombosis and thrombolysis》2022,53(4):788-797
Journal of Thrombosis and Thrombolysis - The complement system (CS) plays a pivotal role in Coronavirus disease 2019 (COVID-19) pathophysiology. The objective of this study was to... 相似文献
994.
The development and implementation of evidence-based, interdisciplinary, consensus-based guidelines is a very important step towards decreasing breast cancer mortality and optimizing the process of early detection, diagnosis, therapy, and follow-up of breast cancer. A revised version of the German S3 guideline was published in February 2008. Different working groups, departments, and organizations participate as coeditors of the new guideline. To fulfill international methodic requirements, a systematic search of the literature with selection of new publications (used as evidence) in the established data bases (Medline, BIOSIS, Previews, CDSR, ACP Journal Club, DARE, CCTR, CINHAL) and the Guidelines International Network (GIN) was performed for the time period of 2003-2006. Varied specialist opinions concerning diagnosis, therapy, and follow-up of breast cancer were considered in formal consensus processes. In different steps, Nominal Group Process techniques, the Delphi technique, and formal consensus processes were used. Besides differently weighted, study-based recommendations, statements resulting from structured consensus finding by the interdisciplinary group - in terms of good clinical practice - were postulated. 相似文献
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Christian Storm Joerg C. Schefold Thoralf Kerner Willi Schmidbauer Jola Gloza Anne Krueger Achim Jörres Dietrich Hasper 《Clinical research in cardiology》2008,97(10):768-772
Background Animal studies suggest that the induction of therapeutic hypothermia in patients after cardiac arrest should be initiated
as soon as possible after ROSC to achieve optimal neuroprotective benefit. A “gold standard” for the method of inducing hypothermia
quickly and safely has not yet been established. In order to evaluate the feasibility of a hypothermia cap we conducted a
study for the prehospital setting.
Methods and results The hypothermia cap was applied to 20 patients after out-of-hospital cardiac arrest with a median of 10 min after ROSC (25/75
IQR 8–15 min). The median time interval between initiation of cooling and hospital admission was 28 min (19–40 min). The median
tympanic temperature before application of the hypothermia cap was 35.5°C (34.8–36.3). Until hospital admission we observed
a drop of tympanic temperature to a median of 34.4°C (33.6–35.4). This difference was statistically significant (P < 0.001). We could not observe any side effects related to the hypothermia cap. 25 patients who had not received prehospital
cooling procedures served as a control group. Temperature at hospital admission was 35.9°C (35.3–36.4). This was statistically
significant different compared to patients treated with the hypothermia cap (P < 0.001).
Conclusions In summary we demonstrated that the prehospital use of hypothermia caps is a safe and effective procedure to start therapeutic
hypothermia after cardiac arrest. This approach is rapidly available, inexpensive, non-invasive, easy to learn and applicable
in almost any situation.
C. Storm & J.C. Schefold are equally contributing first authors.
ClinicalTrials.gov Identifier: NCT00398671 相似文献
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Holger M. Nef Helge Möllmann Astrid Joseph Christian Troidl Sandra Voss Maximilian Rauch Ralf Kinscherf Achim Vogt Michael Weber Christian W. Hamm Albrecht Elsässer 《Clinical research in cardiology》2009,98(6):355-361