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871.
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Introduction: Adiponectin is anti-inflammatory and anti-tumor cytokine secreted exclusively from adipocytes. Thereis a growing evidence of association between adiponectin gene polymorphism and development of pancreatic cancer.The current study aimed at evaluation of the possible association between selected adiponectin gene polymorphism andthe risk of pancreatic cancer. Methods: Prospective case-control study included 77 patients (29 women and 48 men)with biopsy-proven pancreatic adenocarcinoma and 97 healthy control. Blood samples from all included participantswere genotyped for 3 single nucleotide polymorphism (SNPs) of adiponectin genes (rs1501299C>A, rs266729C>G andrs2241766G>T) by PCR. Clinical, biochemical, and radiological data analyzed. Results: We demonstrated a significantassociation between the three studied SNPs (rs1501299, rs266729, and rs2241766) and increased risk of pancreaticadenocarcinoma (p<0.001). Furthermore, in clinical correlation analysis, Patients with rs2241766 polymorphismhave a lower frequency of lymph node involvement (p 0.05). Smoking and older age were independent predictors ofpancreatic adenocarcinoma. Conclusion: We provided evidence that variants in adiponectin gene might influence thedevelopment and progression of pancreatic cancer.  相似文献   
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Herein, the effect of a mediums'' pH on the interfacial interactions between proline (Pro) amino acid and tin metal was studied. In this work, acidic and near-neutral pH values were considered. DFT-based calculations and Monte Carlo simulations were carried out in the aqueous phase to understand the role of pH in Pro/tin interactions. To confirm this role in terms of inhibition efficiency, the CC and AC electrochemical techniques were used. Based on the calculated parameters, it was outlined that the partially protonated Pro form exhibits significant affinity to interact with tin metal in near-neutral media. However, in acidic media, its affinity is decreased, whereas the full protonated form was found to be solvated in the solution and its interaction with the tin surface was not favorable. These findings indicated that the inhibition capability of Pro for tin could be better in near-neutral media than in acidic media. This expected behavior was confirmed experimentally, wherein an inhibition effectiveness of around 65% was obtained for Pro at pH 5, and 16% was observed at pH 2. Additionally, the results highlight the capability of employing computational studies to predict the prevention efficiency of anti-corrosion compounds by varying the solution pH.

Herein, the effect of a mediums'' pH on the interfacial interactions between proline (Pro) amino acid and tin metal was studied.  相似文献   
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This study examined the efficacy of the Child-Directed Interaction Training (CDIT) phase of Parent–Child Interaction Therapy for children with an Autism Spectrum Disorder (ASD). Thirty mother–child dyads with children ages 3–7 years with a diagnosis of ASD participated in this randomized controlled study. Following manualized CDIT, statistically significant and meaningful improvements in child disruptive behavior and social awareness as well as maternal distress associated with child disruptive behavior occurred. Across 8 sessions, mothers learned to provide positive attention to their children's appropriate social and play behaviors. Both child and parent changes were maintained at 6-week follow-up. A relatively brief, time-limited, and accessible intervention may be efficacious for improving child and parent behaviors in families of young children with ASD. By decreasing child disruptive behaviors, CDIT may also help to prepare children to benefit further from future interventions.  相似文献   
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This study was conducted to evaluate the effects of ivermectin (IVM) with therapeutic dose (injected with 0.56 mg/kg b.wt.) either alone or combined with alpha lipoic acid (ALA) (50 mg/kg b.wt daily) on expression of testicular insulin‐like growth factor binding protein‐3 (IGFBP‐3) and heat‐shock protein A1 (HSPA1)) genes in the testes, as well as on male rat fertility parameters. Results revealed that expression levels of IGFBP‐3 and HSPA1 were significantly increased in testis of the IVM‐treated group relative to the control group. Furthermore, injection of ivermectin showed a significant decrease in serum testosterone level, sperm count, motility %, live sperm% and index weight of reproductive organs, and a significant increase in sperm abnormalities. Moreover, IVM induced oxidative stress and pathological alterations in the testes. Meanwhile, the administration of ALA with IVM prevented testicular damage and improved all previous parameters. We concluded that ivermectin has undesirable effects on male fertility and altered expression of IGFBP‐3 and HSPA1 genes in the testes, while the administration of alpha lipoic acid can ameliorate the adverse effects of ivermectin.  相似文献   
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Bronchopulmonary cancer muscle metastases are uncommon, especially when they are visible. They can impact any muscle in the body, but the psoas, diaphragmatic, and paravertebral muscles have a clear advantage. We present a case of lateral pterygoid muscle metastasis of squamous cell carcinoma of the lung in a 70-year-old habitual smoker (40 packs per year) presents headaches more marked on the right and progressively worsening. A complementary brain MRI revealed a well-limited oval formation with irregular contours in hypo signal T1 hyper signal T2 heterogeneous, with area of central necrosis of the right pterygoid muscle, which was revealed to be a secondary location of bronchopulmonary malignancy after further examination (CT scan of the cervico-thoraco-abdomino-pelvic region, TEP scan, and biopsy). Moreover, muscle metastases are rarely revealing of primary cancer.  相似文献   
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Post-traumatic hepatic biloma is a rare complication of closed trauma of the abdomen. Generally, biloma occurs spontaneously or secondary to traumatic or iatrogenic injury to the biliary system. It can lead to significant morbidity and mortality if not diagnosed promptly and properly managed. A 4-year-old child was admitted to the emergency room with abdominal pain following a traffic accident. Clinical examinations suspected closed abdominal trauma without biological signs of icteric cholestasis. Abdominal CT scan performed within 24 hours showed a focus of hepatic laceration, and follow-up imaging at 5 days showed post-traumatic intrahepatic cystic formations. This case report aims to emphasize the importance of imaging including ultrasound, CT, MRI, MRI cholangiopancreatography (MRCP), or hepatobiliary cholescintigraphy to establish the diagnosis and guide the therapeutic gestures.  相似文献   
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