全文获取类型
收费全文 | 2530篇 |
免费 | 214篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 84篇 |
妇产科学 | 48篇 |
基础医学 | 335篇 |
口腔科学 | 10篇 |
临床医学 | 247篇 |
内科学 | 502篇 |
皮肤病学 | 42篇 |
神经病学 | 115篇 |
特种医学 | 44篇 |
外科学 | 524篇 |
综合类 | 99篇 |
一般理论 | 2篇 |
预防医学 | 175篇 |
眼科学 | 39篇 |
药学 | 261篇 |
中国医学 | 13篇 |
肿瘤学 | 196篇 |
出版年
2023年 | 24篇 |
2022年 | 27篇 |
2021年 | 82篇 |
2020年 | 76篇 |
2019年 | 72篇 |
2018年 | 58篇 |
2017年 | 73篇 |
2016年 | 83篇 |
2015年 | 103篇 |
2014年 | 104篇 |
2013年 | 137篇 |
2012年 | 191篇 |
2011年 | 212篇 |
2010年 | 126篇 |
2009年 | 89篇 |
2008年 | 171篇 |
2007年 | 157篇 |
2006年 | 137篇 |
2005年 | 138篇 |
2004年 | 96篇 |
2003年 | 92篇 |
2002年 | 65篇 |
2001年 | 50篇 |
2000年 | 36篇 |
1999年 | 41篇 |
1998年 | 16篇 |
1997年 | 24篇 |
1996年 | 9篇 |
1995年 | 12篇 |
1994年 | 9篇 |
1993年 | 7篇 |
1992年 | 22篇 |
1991年 | 13篇 |
1990年 | 17篇 |
1989年 | 17篇 |
1988年 | 11篇 |
1987年 | 13篇 |
1986年 | 11篇 |
1984年 | 10篇 |
1983年 | 10篇 |
1982年 | 7篇 |
1978年 | 9篇 |
1977年 | 6篇 |
1976年 | 10篇 |
1975年 | 6篇 |
1974年 | 9篇 |
1972年 | 11篇 |
1971年 | 7篇 |
1970年 | 6篇 |
1969年 | 6篇 |
排序方式: 共有2750条查询结果,搜索用时 31 毫秒
81.
Rebecca L. Mather Abhijit Parolia Sandra E. Carson Erik Venalainen David RoigCarles Mustapha Jaber ShihChun Chu Ilaria Alborelli Rebecca Wu Dong Lin Noushin Nabavi Elena Jachetti Mario P. Colombo Hui Xue Perla Pucci Xinpei Ci Cheryl Hawkes Yinglei Li Hardev Pandha Igor Ulitsky Crystal Marconett Luca Quagliata Wei Jiang Ignacio Romero Yuzhuo Wang Francesco Crea 《Molecular oncology》2021,15(7):1921
82.
Abhijit S. Dighe Scott Yang Vedavathi Madhu Gary Balian Quanjun Cui 《Journal of orthopaedic research》2013,31(2):227-234
The mesenchymal stromal cells (MSCs) are reported to be immunoprivileged and osteogenic. We hypothesized that the use of allogeneic MSCs for bone repair was possible if they displayed an ability to induce similar osteogenesis in syngeneic as well as in allogeneic hosts. To test this hypothesis we used a cloned bone marrow derived cell, termed D1, isolated from Balb/c mice. The D1 cells were subcutaneously injected in syngeneic Balb/c, allogeneic immunocompetent B6, allogeneic T‐cell deficient NCr nude, and allogeneic B6 Pfp?/? Rag2?/? mice that lack matured T and B cells as well as NK‐cell cytolytic functions. D1 cells formed ectopic bones only in syngeneic or allogeneic immunocompromised hosts but not in allogeneic B6 hosts. The lack of T cells alone in allogeneic NCr mice was sufficient to promote osteogenesis in allogeneic environment. We observed a significantly higher number of T cells, B cells, macrophages and significantly higher expression of interferon gamma (IFN‐γ) in B6 allogeneic implants as compared to the syngeneic implants. These factors correlated with severe inhibition of expression of alkaline phosphatase, osteocalcin, and runx2 genes in the implants from B6 mice. Our data suggest that strategies to inhibit T cells and IFN‐γ functions will be useful for bone repair mediated by allogeneic MSCs. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 227–234, 2013 相似文献
83.
84.
Yogesh Patidar Meena Gupta Geeta A Khwaja Debashish Chowdhury Amit Batra Abhijit Dasgupta 《Annals of Indian Academy of Neurology》2013,16(3):428-431
Apraxia of speech (AOS) is a rare, but well-defined motor speech disorder. It is characterized by irregular articulatory errors, attempts of self-correction and persistent prosodic abnormalities. Similar to aphasia, AOS is also localized to the dominant cerebral hemisphere. We report a case of Crossed Aphasia with AOS in a 48-year-old right-handed man due to an ischemic infarct in right cerebral hemisphere. 相似文献
85.
Yogesh Patidar Meena Gupta Geeta A. Khwaja Debashish Chowdhury Amit Batra Abhijit Dasgupta 《Annals of Indian Academy of Neurology》2013,16(2):157-162
Aims:
To evaluate clinical profile and short-term outcome of psychogenic non-epileptic seizures (PNES) in Indian adult population.Setting and Design:
A prospective observational study, conducted at tertiary teaching institute at New Delhi.Materials and Methods:
Sixty-three patients with confirmed PNES were enrolled. The diagnosis was based on witnessing the event during video-electroencephalography (Video-EEG) monitoring. A detailed clinical evaluation was done including evaluation for coexistent anxiety or depressive disorders. Patients were divided into two groups on the basis of excessive or paucity of movements during PNES attacks. Patients were followed-up to 12 months for their PNES frequency.Statistical Analysis:
Means and standard deviations were calculated for continuous variables. Chi-square and Students t-test were used to compare categorical and continuous variables respectively.Results:
The mean age at onset of PNES was 25.44 years; with F:M ratio of 9.5:1. Coexistent epilepsy was present in 13 (20.63%) cases. Twenty-two patients (44%) with only PNES (n = 50) had received antiepileptic drugs. Out of 63 patients of PNES 24 (38.1%) had predominant motor phenomenon, whereas 39 (61.9%) had limp attacks. The common features observed were pre-ictal headache, ictal eye closure, jaw clenching, resistant behavior, ictal weeping, ictal vocalization, and unresponsiveness during episodes. Comorbid anxiety and depressive disorders was seen in 62.3% and 90.16% patients, respectively. Short-term (6-12 months) outcome of 45 patients was good (seizure freedom in 46.66% and >50% improvement in 24.44% cases).Conclusion:
PNES is common, but frequently misdiagnosed and treated as epileptic seizures. A high index of suspicion is required for an early diagnosis. Proper disclosure of diagnosis and management of the psychiatric comorbidities can improve their outcome.Limitation:
Limited sample size and change in seizures frequency as the only parameter for the assessment of the outcome are the two major limitations of our study. 相似文献86.
Diana Marcela Muñoz Takyee Tung Sameer Agnihotri Sanjay Singh Abhijit Guha Gelareh Zadeh Cynthia Hawkins 《Glia》2013,61(11):1862-1872
Gliomas are recognized as a heterogeneous group of neoplasms differing in their location and morphological features. These differences, between and within varying grades of gliomas, have not been explained solely on the grounds of an oncogenic stimulus. Interactions with the tumor microenvironment as well as inherent characteristics of the cell of origin are likely a source of this heterogeneity. There is an ongoing debate over the cell of origin of gliomas, where some suggest a progenitor, while others argue for a stem cell origin. Thus, it is presumed that neurogenic regions of the brain such as the subventricular zone (SVZ) containing large numbers of neural stem and progenitor populations are more susceptible to transformation. Our studies demonstrate that K‐rasG12D cooperates with the loss of p53 to induce gliomas from both the SVZ and cortical region, suggesting that cells in the SVZ are not uniquely gliomagenic. Using combinations of doxycycline‐inducible K‐rasG12D and p53 loss, we show that tumors induced by the cooperative actions of these genes remain dependent on active K‐ras expression, as deinduction of K‐rasG12D leads to complete tumor regression despite absence of p53. These results suggest that the interplay between specific combinations of genetic alterations and susceptible cell types, rather than the site of origin, are important determinates of gliomagenesis. Additionally, this model supports the view that, although several genetic events may be necessary to confer traits associated with oncogenic transformation, inactivation of a single oncogenic partner can undermine tumor maintenance, leading to regression and disease remission. GLIA 2013;61:1862–1872 相似文献
87.
Satyaveni Malasala Jitendra Gour Md. Naiyaz Ahmad Srikanth Gatadi Manjulika Shukla Grace Kaul Arunava Dasgupta Y. V. Madhavi Sidharth Chopra Srinivas Nanduri 《RSC advances》2020,10(71):43533
A facile method was developed for the synthesis of quinazolinone derivatives in a one-pot condensation reaction via in situ amine generation using ammonia as the amine source and with the formation of four new C–N bonds in good to excellent yields. With the optimised method, we synthesized a library of piperazine linked quinazoline derivatives and the synthesized compounds were evaluated for their inhibitory activity against Mycobacterium tuberculosis. The compounds 8b, 8e, 8f, 8m, 8n and 8v showed potent anti-mycobacterial activity with MIC values of 2–16 μg mL−1. All the synthesized compounds follow Lipinski''s rules for drug likeness.A facile method was developed for the synthesis of quinazolinone derivatives in a one-pot condensation reaction via in situ amine generation using ammonia as the amine source and with the formation of four new C–N bonds in good to excellent yields. 相似文献
88.
Bhilare Neha V. Dhaneshwar Suneela S. Mahadik Kakasaheb R. Dasgupta Arunava Zende Tejal Kapoor Siddhart 《Pharmaceutical Chemistry Journal》2020,54(7):678-688
Pharmaceutical Chemistry Journal - The long-course treatment of tuberculosis with isoniazid (INH) leads to hazardous side effects on liver and poor patient compliance. To overcome these toxic... 相似文献
89.
90.