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??Abstracts?? Objective To investigate the changes of ventricular late potentials ??VLP?? in children with vasovagal syncope of vasodepressor response ??VVS-V??. Methods Totally 184 children ??aged from 4 to 14 years old??the average age being ??10.54±2.15?? years old?? had been diagnosed with VVS-V by head-up tilt table test ??HUTT?? ??study group?? from July 2006 to January 2013 in the Second Xiangya Hospital of Central South University?? male 85 cases?? the average age of ??10.85±2.01?? years old?? female 99 cases?? mean age ??10.27±2.24?? years old. Totally 105 healthy children were matched as controls. All subjects underwent VLP examination. Investigate the difference in HR?? TQRS?? LAS40 and RMS40 between the study group and the control group. Results Compared with the control group?? in the study group heart rate ??HR?? decreased ???83.96±12.27?? beats/min vs??87.28±13.75?? beats/min?? t = -2.113?? P??0.05???the total QRS time??TQRS?? ???84.89±12.05?? ms vs ??81.21±8.23?? ms?? t = 3.070?? P??0.05?? and high frequency and low amplitude limit??LAS40?? ???62.43±19.17?? ms vs ??56.79±1.83?? ms?? t = 2.442?? P??0.05?? were prolonged??and the root mean square plant??RMS40?? increased ???28.73±7.23?? μV vs ??26.89±7.36?? μV?? t = 2.059?? P??0.05??. Conclusions Compared to healthy controls??in VVS-V children HR reduces??TQRS and LAS40 prolong??and RMS40 increases. It suggests that VVS-V childrenare more likely to have cardiovascular incidents.     

Hemorrhagic cholecystitis: ultrasound and CT imaging findings—a retrospective case review series

Emergency Radiology - Gallbladder pathology is diverse, and imaging tests are essential tools for its diagnosis. Acute cholecystitis has multiple manifestations or complications, one of which is...     

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??Airway mucus hypersecretion is an important feature of chronic respiratory diseases. Viral infection is a common factor inducing airway mucus hypersecretion. Understanding the relationship between the viral infection and airway mucus hypersecretion and mechanism is very important to preventing and reducing airway mucus hypersecretion??decreasing the mortality of chronic respiratory diseases. The increase of MUC5AC expression is the major pathological basis of airway mucus hypersecretion??so it is necessary to discuss the signal transduction pathway of MUC5AC secretion caused by common respiratory virus infection.     

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??Objective To compare pbp2b??ply and lytA genes PCR with cerebral spinal fluid culture in diagnosis of Streptococcus pneumoniae meningitis and prediction of its susceptibility. Methods A nested PCR targeting pbp2b and another two S.pneumoniae specific PCR targeting the genes of pneumolysin??ply?? and autolysin??lytA?? were developed for detection of S.pneumoniae in cerebral spinal fluid from bacterial meningitis patients. The three PCR results and culture were compared. The consistency of penicillin susceptibility PCR ??using resistant and susceptible primers respectively????sequencing and culture-based phenotypic penicillin resistant results were compared. Results Of the 161 specimens studied??there were 25 cases of S.pneumoniae infection confirmed by different methods??16 by pbp2b PCR??16 by lytA PCR??14 by ply PCR and 9 by cerebrospinal fluid culture??. Of the 16 pbp2b positive specimens??penicillin sensitive and resistant sequence types accounted for half??respectively. Four of the 16 pbp2b positive specimens had culture-based phenotypic penicillin-resistant result. Three of 4 were consistent with penicillin susceptibility PCR result. The results of susceptibility PCR targeting pbp2b was consistent with sequencing result. New sequence types were found but there were no new point mutations in these strains when compared with GenBank ??http??//blast.ncbi.nlm.nih.gov/Blast.cgi??. Penicillin resistance in pneumococcal meningitis was 66.67%??6/9?? by culture phenotype and 50%??8/16?? by PCR and sequencing when culture was negative. Conclusion Pbp2b can serve as a good target gene to detect S.pneumoniae and predict its penicillin susceptibility??which is especially important when culture is negative.     

n-3 Polyunsaturated fatty acid supplementation restored impaired memory and GABAergic synaptic efficacy in the hippocampus of stressed rats

While chronic stress induces dendritic atrophy in the hippocampus and impairs learning and memory, supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) is known to improve learning and memory of control rats. Whether n-3 PUFA supplementation improves dendritic morphology, synaptic transmission, and memory of chronically stressed rats remains unknown. In this work, we randomly assigned male Sprague-Dawley rats in four experimental groups: two unsupplemented groups, control and stress, and two supplemented groups with n-3 PUFA (DHA and EPA mix), control?+?n-3 PUFA and stress?+?n-3 PUFA. Dendritic morphology and synaptic transmission in the hippocampus were evaluated by Golgi stain and patch-clamp tools, respectively. The Y-maze and Morris water maze were used to analyze the effects of chronic stress on memory. Supplementation with n-3 PUFA improved dendritic architecture and restored the frequency of inhibitory post-synaptic currents of hippocampal pyramidal neurons of rats from stress group. In addition, n-3 PUFA supplementation improved spatial memory. Our results demonstrate that n-3 PUFA supplementation had three beneficial effects on stressed rats: prevented or compensated dendritic atrophy in CA3; restored the probability of GABA release in CA1; and improved spatial memory. We argue that n-3 PUFA supplementation can be used in treating stress-related psychiatric disorders such as depression and anxiety.     

Geometrical Measurement of Central Tumor Location in cT1N0M0 NSCLC Predicts N1 but Not N2 Upstaging

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