通便汤为主治疗便秘型肠易激综合征120例

目的:观察以通便汤为主治疗便秘型肠易激综合征的临床疗效.方法:对120例患者予通便汤治疗,配合轴保持短缩法、心理调节和饮食指导等辅助手段.结果:治愈65例,显效41例,有效12例,无效2例,总有效率为98.3％.结论:以通便汤为主治疗便秘型肠易激综合征疗效显著.     

在美国开诊所的中国医生

电影《阿甘正传》讲述的是美国南方阿拉巴马州的故事,重温这部电影时,片中出现的美丽街市,使我的思绪不禁又飘回了在美国阿拉巴马学习生活的日子。     

uPA和FAK在肝癌组织中的表达及相关性研究

目的研究尿激酶型纤溶酶原激活剂(uPA)和黏着斑激酶(FAK)在原发性肝癌中的表达及其意义。方法采用免疫组织化学SP法检测34例原发肝癌组织、14例癌旁正常肝组织中uPA和FAK的表达情况。结果原发性肝癌组织中uPA和FAK表达定位于细胞质和细胞核,其表达明显高于癌旁正常肝组织(P均<0.05)。二者的表达与性别、年龄、肿瘤大小等无显著相关性(P均>0.05),与淋巴结转移、组织分化及癌栓等有显著性关(P均<0.05);uPA与FAK表达呈明显正相关(P<0.05)。结论 uPA与FAK在原发性肝癌呈高表达,且与原发性肝癌的发生、发展和转移密切相关。     

喂养方式对乳牙龋病的影响

目的:探讨喂养方式与乳牙龋齿之间的关系。方法:调查260例具有完整乳牙列儿童的喂养方式、患龋率、dmft情况,并对喂养方式与乳牙患龋率进行卡方检验,喂养方式与乳牙患者龋均进行方差分析。结果:母乳喂养者,乳牙患龋率、龋均发病率均最低,与混合喂养者、人工喂养者相比,有显著性差异;混合喂养者与人工喂养者之间无显著性差异。结论:正确的母乳喂养对预防乳牙龋齿的发生有重要意义。     

护理干预对经皮肾镜钬激光碎石术后患者疼痛的影响

目的 探讨护理干预对经皮肾镜钬激光碎石术后患者疼痛的影响.方法 选择我科86例肾结石,随机分为对照组和护理干预组,对照组经皮肾镜钬激光碎石术前后接受常规护理,护理干预组除接受常规护理外还予特殊护理干预,术后对两组疼痛程度进行比较.结果 经皮肾镜钬激光碎石术后,护理干预组疼痛程度明显低于对照组,对照组疼痛评分(38.66 ±1.48)分,护理干预组疼痛评分(27.32±2.16)分,两组比较差异具有统计学意义(t=3.6895,P＜0.05).结论 护理干预可减轻经皮肾镜钬激光碎石术后患者的疼痛程度,提高医疗护理质量.     

布托啡诺预先给药对大鼠心肌缺血再灌注损伤的影响

Objective To investigate the effects of butorphanol pretreatment on myocardial ischemia-reperfusion (IR) injury in rats. Methods Forty healthy male SD rats weighing 200-250 g were randomly divided into 5 groups (n = 8 each) : sham operation group (group S); IR group; butorphanol pretreatment group (group B); Nor-BNI group (group N) and glibenclamide group (group G) . In group IR, B, N and G, myocardial IR was produced by occlusion of left anterior descending artery (LAD) for 30 min followed by 120 min reperfusion. In group S and IR, normal saline S ml/kg was injected via femoral vein 10 min before ischemia and then continuously infused at a rate of 5 ml· kg -1· h-1 iv. In group B, butorphanol 25 μg/kg was injected via femoral vein 10 min before ischemia and the rest method was the same as that described in group IR. In group N, Nor-BNI 2 mg/kg (a selective κ-opioid receptor antagonist) was injected via femoral vein 20 min before ischemia and the rest method was the same as that described in group B. In group G, glibenclamide 1 mg/kg (a KATP channel blocker) was injected via femoral vein 10 min before ischemia and the rest method was the same as that described in group B. Blood samples were taken from femoral artery at 120 min of reperfusion for determination of the concentrations of serum TNF-α, IL-6 and IL-10 by ELISA. Myocardial infarct area and ischemic area were measured by TTC staining and myocardial infarct size was calculated. Results The concentrations of serum TNF-a, IL-6 and IL-10 were significantly higher in the other four groups than in group S (P < 0.05) . The concentrations of serum TNF-α andIL-6 were significantly decreased while IL-10 increased, and the myocardial infarct size was significantly decreased in group B, N and G as compared with group IR ( P < 0.05) . The concentrations of serum TNF-α and IL-6 were significantly increased while the concentration of IL-10 decreased) and the myocardial infarct size was significantly increased in group N and G as compared with group B ( P < 0.05). Conclusion Butorphanol pretreatment can protect the myocardium against IR injury in rate via activating κ receptor and KATP channel.     

地震后被困196 h严重脑损伤一例

1 病历资料 伤者,男,44岁.汶川大地震发生后196 h被救并转送来院.极度脱水,意识不清、谵妄,体温35.2℃,心率118次/min,呼吸浅快32次/min,血压70/40 mm Hg(1 mmHg=0.133 Kpa),SO20.6～0.7,无尿,多处外伤并感染、流脓.     

善宁治疗食道—胃底静脉曲张出血的临床观察及护理

善宁是一种人工合成的天然生长抑素的八肽衍生物 ,成分为乙酸奥曲肽 ,它能明显降低肝硬化门脉高压病人肝脏的血流量、门静脉压力和食管曲张静脉的压力。 1 999年 5月～ 2 0 0 0年 5月 ,我科应用善宁治疗肝硬化所致食管—胃底静脉曲张破裂出血 ,效果满意且不良反应轻。1　临床资料1 1　病例选择　本组 2 1例 ,男 1 8例 ,女 3例 ,年龄 35～ 76岁 ,平均 4 8岁。 2 1例均系肝硬化致门脉高压 ,其中肝炎后肝硬化 1 7例 ,酒精性肝硬化 4例。经胃镜检查证实食管或胃底静脉中度或重度曲张 ,以呕血为主 ,大多同时伴有黑便 ,其中伴有黄疸的 1 0例 ,腹…     

产超广谱β-内酰胺酶细菌106株耐药性调查

目的　了解临床产超广谱 β 内酰胺 (ESBLS)酶细菌的检出率 ,并对其耐药性进行探讨。　方法　菌株鉴定采用法国梅里埃公司API系列产品 ,药敏试验采用纸片扩散法 ,根据产ESBLS 酶细菌调查检测结果 ,结合临床 ,分析其发生及发展情况。　结果　 85 8株革兰阴性杆菌中检出产ESBLS 酶菌10 6株 ,检出率 12 35 % ;其中 4 1株来源于医院感染患者的标本 ,其检出率为 34 17% ;6 5株来源于非医院感染患者的标本 ,其检出率为 8 81% ,显著低于医院内感染病人 (P <0 0 1)。产ESBLS 酶菌对氨苄西林的耐药率达 94 34% ,耐药率最低为亚安培南 4 7%。　结论　医院感染病人产ESBLS 酶细菌的发生率明显高于普通住院病人 ,产ESBLS 酶细菌对大多数常用抗生素耐药率超过 5 0 %。