不同途径给予Neuritin对大鼠骨折愈合的影响

目的观察口服与局部注射Neuritin对SD大鼠骨折模型骨折愈合的促进作用。方法将90只健康雄性SD大鼠按体质量随机分为对照组(Ⅰ组)、口服组(Ⅱ组)、局部注射组(Ⅲ组),每组各30只。各组动物取右侧股骨,切断中段股骨后行髓内逆行克氏针内固定术制作骨折模型。Ⅰ组不予特殊处理,Ⅱ、Ⅲ组分别给予Neuritin口服、局部注射处理,并分别于1、2、3周处死,通过拍摄X线片、测量骨痂体积、做病理切片进行相关分析。结果术后1周各组间变化差异不大,术后2周,Ⅱ、Ⅲ组与同期Ⅰ组比较,骨折愈合骨化速度有显著差异,均明显快于Ⅰ组(P<0.05);Ⅱ、Ⅲ组间亦有差异,Ⅲ组明显快于Ⅱ组大鼠(P<0.05)。骨痂体积测量显示:术后2周,Ⅱ、Ⅲ组与Ⅰ组比较,骨痂体积大小有显著差异,均明显大于Ⅰ组(P<0.05);Ⅱ、Ⅲ组间比较,Ⅲ组明显大于Ⅱ组大鼠(P<0.05)。HE染色显示:Ⅲ组早期即出现肉芽组织纤维化过程,相同时间点内其软骨细胞、成骨细胞明显多于Ⅰ、Ⅱ组(P<0.05)。结论口服与局部注射Neuritin后均可使动物骨折模型的骨痂含量增加,骨痂骨化速度增快,但局部注射途径更优于口服治疗。     

小腿创伤致多脏器功能障碍治疗体会

多脏器功能障碍综合症(multiple organ dysfunction sysdrome，MODS)是因感染、创伤、休克等危重病时伴有2个或2个以上器官功能障碍或衰竭的病理生理过程。MODS分为原发性和继发性，原发性MODS是打击的直接结果，器官功能不全发生早，并与打击本身有直接关系；继发性MODS并不是机体对打击本身起反应，     

老年痴呆患者跌倒危险因素的临床分析

Objective To explore the risk factors for falls in patients with dementia. Methods Totally 118 patients diagnosed with dementia were divided into fails group and no fails group. The scores of mini-mental state examination (MMSE), clinical dementia rating (CDR) , activity of daily living scale (ADL), neuropsychiatric inventory (NPI) and unified Parkinson's disease rating scale (UPDRS) were compared between the two groups. The relationship between falls and their risk factors were analyzed by logistic regression model. Results The NPI and UPDRS scores were higher in falls group than in no falls group(t=2. 237,2. 213; both P<0.05). Multivariate analysis showed that dyskinesia and behavior disorders were significantly associated with an increased risk of falls (β=0.77 and 0.86, both P<0.05). Conclusions Dyskinesia and behavior disorders may be related to fails in patients with dementia and intervention measures of these risk factors are very essential.     

老年痴呆患者跌倒危险因素的临床分析

Objective To explore the risk factors for falls in patients with dementia. Methods Totally 118 patients diagnosed with dementia were divided into fails group and no fails group. The scores of mini-mental state examination (MMSE), clinical dementia rating (CDR) , activity of daily living scale (ADL), neuropsychiatric inventory (NPI) and unified Parkinson's disease rating scale (UPDRS) were compared between the two groups. The relationship between falls and their risk factors were analyzed by logistic regression model. Results The NPI and UPDRS scores were higher in falls group than in no falls group(t=2. 237,2. 213; both P<0.05). Multivariate analysis showed that dyskinesia and behavior disorders were significantly associated with an increased risk of falls (β=0.77 and 0.86, both P<0.05). Conclusions Dyskinesia and behavior disorders may be related to fails in patients with dementia and intervention measures of these risk factors are very essential.     

临床路径在关节镜辅助下胫骨平台骨折手术治疗中的实施效果评价研究

目的评价临床路径在关节镜辅助下胫骨平台骨折手术治疗中的实施效果。方法选取入院行膝关节镜辅助治疗的胫骨平台骨折患者为研究对象,分为对照组和试验组各40例。对照组采用传统的治疗模式,试验组采取临床路径模式。对两组患者的住院天数、医疗费用、满意度、健康知识掌握情况等进行比较。结果试验组患者的住院天数、医疗费用明显下降,患者满意度及健康知识掌握情况均提高,与对照组比较差异均有统计学意义(P<0.05)。结论关节镜辅助下胫骨平台骨折手术治疗的临床路径值得在临床推广应用。     

肺部多发球形阴影表现的结核病

以多发球形阴影表现的肺结核病，较为少见。确定诊断往往有一定困难，极易误诊。     

消疬膏治疗颈部淋巴结核40例报告

我们自1996年1月～1999年1月在口服抗结核药物同时,局部外敷自制消疬膏治疗单纯颈部淋巴结核40例,效果满意,报告如下. 资料与方法 本组40例.男18例,女22例.年龄16～69岁,平均39岁.病程3～16个月,平均3.9个月.     

低总压非加压供氧装备生理试验评价

目的验证提高普通供氧装备使用升限高度的可能性，旨在为新型喷气式教练飞机采用低总压制度，实现简化装备提供生理试验依据。方法在完成系统装备动态供氧性能试验的基础上，６名健康男性受试者使用ＹＸ－６氧气系统装备，在低压舱内分别上升６．２ｋｍ、５．３ｋｍ和１３．１ｋｍ，测试各生理指标的变化。结果ＹＸ－６氧气系统可满足飞行员在巡航高度上长时间飞行的供氧要求。在最大升限高度１３．１ｋｍ上供纯氧可以为飞行员提供０．５ｍｉｎ～１ｍｉｎ，降至１２．０ｋｍ以下高度，共有不少于２ｍｉｎ的应急供氧救生时间。满足了新型喷气式教练飞机战术技术要求。在高空１３．１ｋｍ试验中，受试者出现了明显的缺氧反应，如呼吸加深加快，肺通气量增加，心率增快，心电Ｔ波幅度降低，脑电出现７ｃ／ｓ慢波，血氧饱和度骤然下降至７０％，与预研及国外报道一致。结论非加压供氧装备在１３．１ｋｍ高度上的肺总压是１６．３ｋＰａ，属于低总压供氧制度，只能作为飞机从升限高度紧急下降的应急措施，不能作为继续飞行的保证措施。     

老年痴呆患者跌倒危险因素的临床分析

Objective To explore the risk factors for falls in patients with dementia. Methods Totally 118 patients diagnosed with dementia were divided into fails group and no fails group. The scores of mini-mental state examination (MMSE), clinical dementia rating (CDR) , activity of daily living scale (ADL), neuropsychiatric inventory (NPI) and unified Parkinson's disease rating scale (UPDRS) were compared between the two groups. The relationship between falls and their risk factors were analyzed by logistic regression model. Results The NPI and UPDRS scores were higher in falls group than in no falls group(t=2. 237,2. 213; both P<0.05). Multivariate analysis showed that dyskinesia and behavior disorders were significantly associated with an increased risk of falls (β=0.77 and 0.86, both P<0.05). Conclusions Dyskinesia and behavior disorders may be related to fails in patients with dementia and intervention measures of these risk factors are very essential.