继发于泌尿道感染的MERS2例临床分析

目的分析继发于泌尿道感染的伴有胼胝体压部可逆性病灶的临床症状轻微的脑炎/脑病（MERS）的临床特点。方法收集2例泌尿道感染继发MERS患者的临床资料,分析其临床特点。结果例1患者为青年男性,例2患者为中年女性。2例患者发病前均有发热、尿频、尿痛等泌尿道感染症状,随后出现头痛、精神异常、神志不清等神经系统症状,早期均给予左氧氟沙星针抗感染治疗。发病早期头颅MRI提示胼胝体压部T2WI-flair高信号、DWI高信号;腰穿检查提示脑脊液压力增高,脑脊液实验室检查正常。予以抗感染、甘露醇脱水降颅内压、营养支持治疗后好转,1个月后复查头颅MRI提示胼胝体压部病灶消失。结论泌尿道感染可能是MERS的病因之一,其致病菌为大肠埃希菌。若早期出现泌尿道感染症状,随后出现头痛、精神异常、神志不清等神经系统症状,也要考虑MERS的可能。     

基质金属蛋白酶-7血清水平及其基因-181A/G多态性对颈动脉斑块稳定性的影响

Objective To explore the influence of plasma matrix metalloproteinase-7 ( MMP-7 ) levels and genetic polymorphism of MMP-7 - 181 A/G on the stability of carotid plaque.Method According to carotid ultrasound examination, 503 patients with carotid atherosclerotic lesions were consecutively recruited and divided into vulnerable plaque group (n = 118) and stable plaque group (n = 385).Plasma MMP-7 levels were measured by enzyme-linked immunosorbent assay (ELISA), and MMP-7 -181 A/G genotypes were determined by polymerase chain reaction-restiction fragment length polymorphism (PCR-RFLP).Results Plasma MMP-7 levels in carotid vulnerable plaque group were significantly enhanced as compared to stable plaque group (t =5.49, P =0.00).The frequency of MMP-7 -181G allele in vulnerable plaque group was significantly higher than that in stable plaque group (11.4% vs 7.0% ,χ2 = 4.78, P= 0.029).Compared to AA genotype, the genotypes with - 181G allele (AG + GG) significantly increased susceptibility to carotid vulnerable plaque ( χ2 = 5.01, OR = 1.81, P = 0.025 ) .When further analyzing the relationship between genotype and plasma MMP-7 levels, no significant differences of plasma MMP-7 levels were observed between AA genotype and AG + GG genotype in stable plaque group.However, in vulnerable plaque group, plasma MMP-7 levels of AG + GG genotype were significantly higher than that of AA genotype( t = 2.62, P = 0.01).Conclusion The present findings suggest that plasma MMP-7 level may be a biomarker for carotid vulnerable plaque.Genetic polymorphism of - 181 A/G in MMP-7 promoter may affect the expression of MMP-7, and seems to be implicated in susceptibility to carotid vulnerable plaque.