肾膀胱双原发癌伴子宫肌瘤红色变性1例报告

患者,女,年龄43岁。因下腹部肿物半年伴尿频、阴道不规则出血,拟诊为子宫肌瘤,于1997年4月12日收住院。体检:下腹部微膨隆,子宫如孕16周大小,质硬尚活动。右肾区叩击痛。B超及CT均显示子宫及右肾有实质占位性病变。IVU示右肾上中极肾盏受压变形,杯口消失;膀胱受压变形,膀胱内可见条索状密度增高影,提示为右肾及膀胱肿瘤。膀胱镜检查见膀胱顶部受压,左后壁粘膜生长一水草样肿物,基底细小,长1.5cm。在粘膜下注射无水乙醇后钳夹基底全部取出。同月18日在全麻下行右肾癌根治子宫全切术。术后恢复良好,定期膀胱灌注化疗,随访12个月未见肿瘤复…     

脑损伤后神经细胞凋亡变化及黄体酮保护作用的研究

目的：观察脑损伤后神经细胞凋亡变化及黄体酮的保护作用。方法雄性SD大鼠随机分为假手术组、脑损伤组和黄体酮治疗组,大鼠脑损伤模型制作是利用改良的Feeney自由落体损伤装置。各组于伤后24、48、72 h取材。用免疫组织化学法观察大鼠皮质和海马CA1区半胱氨酸天冬氨酸蛋白酶-3（Caspase-3）的表达水平变化。结果脑损伤组的Caspase-3阳性细胞数在皮质和海马CA1区较假手术组显著增加,黄体酮治疗组与脑损伤组比较,Caspase-3阳性细胞数明显减少,差异有统计学意义（P＜0.05）。结论黄体酮抑制脑损伤后Caspase-3的表达可能是黄体酮脑保护作用机制之一。     

失血性休克后肠淋巴液引流恢复小鼠肾组织ACE/ACE2平衡的作用

目的:观察失血性休克后肠淋巴液(PHSML)引流对失血性休克小鼠肾组织血管紧张素转换酶(ACE)/ACE2平衡的作用。方法:复制小鼠失血性休克模型,随机分为休克组与休克+引流组,行液体复苏;休克+引流组液体复苏后,引流肠淋巴液。在液体复苏后6 h,检测肾组织ACE、ACE2、血管紧张素II(Ang II)1型受体(AT1R)、Mas相关G蛋白偶联受体(MasR)的mRNA表达以及Ang II、Ang(1-7)含量。结果:失血性休克提高了肾组织ACE mRNA、AT1R mRNA和Ang II水平,降低了ACE2 mRNA、MasR mRNA和Ang(1-7)水平,PHSML引流抑制了失血性休克对ACE2和AT1R mRNA表达的影响;同时PHSML引流也降低了失血性休克增加ACE/ACE2、Ang II/Ang(1-7)和AT1R/MasR比值的作用。结论:PHSML引流恢复了失血性休克后肾组织的ACE/ACE2平衡,有利于减轻失血性休克所致的肾损伤。     

突发公共卫生事件预警系统的建立及作用

建立科学合理的卫生信息网和疫情信息快速反应机制是预防和控制突发公共卫生事件的重要措施。突发公共卫生事件预警系统从疫情首发地及时获取疫情信息，自动启动疫情上报功能，在第一时间传递到疾病控制中心和卫生局，从而建立了一个涵括全市人口、以个人健康档案与家庭档案为中心，具有传染病诊断报告、密切接触／高危／易感人群筛选、传染病预警等功能的疫情信息快速反应机制。     

急诊科急性心肌梗死抢救护理流程模式的改进

Objective To increase the success rate of first-aid and nursing of patients with acute infarct of cardiac muscle in emergency departments.Methods A total of 50 patients with acute infarct of cardiac muscle were taken,for seeking for the most convenient,effective flow model for first-aid and nursing under current conditions,which has a smooth cooperation with doctors,and shortens the time of patients staying in hosptal.Results The 50 patients were primarily first-aided in emergency department,and shew a stable status of disease,and were sent to the complex ICU or the cardiacology department in the in-patient section with care.The success rate was 94%.Compared with 50 patients in the past,the success rate was increased by 10% (P＜0.05).The time for staying in hospital was reduced to 6 rain for a patient at a time in average,from the tradiational average time for a patient at a time of 15.5 rain.Conclusions This exploration in nursing model for first-aid and nursing of patients with acute infarct of cardiac muscle in emergency departments provides an improvement which can closely match with doctors,and increase the success rate of first aid.It clearly shortens the in-hospital time for patients.The model gives valuable time for the first-aid process which shows time is life,and increases the patients' satisfication degree.     

急诊科急性心肌梗死抢救护理流程模式的改进

Objective To increase the success rate of first-aid and nursing of patients with acute infarct of cardiac muscle in emergency departments.Methods A total of 50 patients with acute infarct of cardiac muscle were taken,for seeking for the most convenient,effective flow model for first-aid and nursing under current conditions,which has a smooth cooperation with doctors,and shortens the time of patients staying in hosptal.Results The 50 patients were primarily first-aided in emergency department,and shew a stable status of disease,and were sent to the complex ICU or the cardiacology department in the in-patient section with care.The success rate was 94%.Compared with 50 patients in the past,the success rate was increased by 10% (P＜0.05).The time for staying in hospital was reduced to 6 rain for a patient at a time in average,from the tradiational average time for a patient at a time of 15.5 rain.Conclusions This exploration in nursing model for first-aid and nursing of patients with acute infarct of cardiac muscle in emergency departments provides an improvement which can closely match with doctors,and increase the success rate of first aid.It clearly shortens the in-hospital time for patients.The model gives valuable time for the first-aid process which shows time is life,and increases the patients' satisfication degree.     

周围神经减压术治疗糖尿病性周围神经病的临床疗效观察

目的:探讨周围神经减压术治疗糖尿病性周围神经病的临床疗效.方法:应用腓总神经、腓深神经及胫后神经三处周围神经减压术治疗17例糖尿病性周围神经病患者,并回顾性分析其临床疗效.结果:患者术后疼痛缓解率为100%,麻木的缓解率为94.1%,神经传导速度明显改善.结论:周围神经减压术是治疗糖尿病性周围神经病的有效方法.     

后腹腔镜切除巨大肾上腺囊肿1例报告

肾上腺巨大囊肿临床少见。2006年5月,我院应用后腹腔镜技术成功切除1例,报道如下。1临床资料患者女,37岁,体重43kg,身高153cm。因体检发现左侧肾上腺囊性肿物1周于2006年5月18日门诊以“左侧肾上腺囊肿”收入院。既往无外伤史,无发热、头晕、肢体无力、多尿,工作正常。入院查体血压120/70mm Hg,心肺正常,腹部柔软,左上腹可触及囊性肿物,边界不清。B超检查左侧肾上腺区可探及巨大低回声液性暗区,暗区内可见不规则分隔,18.0cm×10.2cm×10.0cm。CT见左侧肾上腺区巨大囊性肿物,强化后囊壁较厚,血液循环丰富,失去正常解剖关系,与周围组织关系密切,左侧肾脏被肿物挤压向下严重移位。MRI检查肿物将左侧肾脏挤压向下移位明显(图1)。2006年5月20日在静脉全身麻醉下应用后腹腔镜技术切除巨大左侧肾上腺囊肿。术中腹膜后腔气腹压力维持在12~14mm Hg(1mm Hg=0.133kPa)。左肾上腺巨大囊肿内侧与腹主动脉相连,下极与左肾上极和肾动脉相邻,界限不清。超声刀沿囊肿表面切开粘连组织,仔细分离清楚囊肿与周围组织界限,找出间隙,钝性分离。自囊肿壁背侧切开囊肿,吸出囊内暗红色液体1100m...     

用核酸原位杂交技术观察细粒刺球绦虫66kDa抗原mRNA在虫体上的细胞定位

目的用核酸原位杂交技术观察细粒棘球绦虫66kDa抗原mRNA在虫体上的细胞定位以及在虫体发育的不同时期mRNA含量的变化.方法以66kDa抗原的cDNA克隆EgA31为模反制备RNA探针,与细粒棘球绦虫原头蚴、育囊和成虫虫体进行原位杂交实验.结果原位杂交实验显示EgA31 mRNA主要位于原头蚴和成虫的皮层下某种细胞中，暗藏在棘球蚴育囊的生发层中也存在这种细胞.在原头蚴向成虫的发育过程中虫体吸盘处细胞内EgA31 mRNA含量显著增加，结论含EgA31 mRNA的细胞很可能是皮层细胞EgA31蛋白可能参与吸盘上肌纤维的收缩作用并与虫体的免疫逃避功能有关.