核糖体蛋白家族成员与 MDM 2-p53通路调控的研究进展

肿瘤是危害人类生命健康的最主要的疾病之一。 p53是目前为止研究最多的抑癌基因，p53的功能紊乱是肿瘤发生最主要的原因。核糖体蛋白发挥核糖体外功能抑制鼠双微体基因2（ murine double minute 2， MDM 2）并激活 P 53是近十年的研究热点。本文就核糖体蛋白与 MDM 2-p 53通路调控关系及其与肿瘤治疗的研究进展进行综述。     

怀孕女性孕期常见症状及护理

<正>孕妇的整个妊娠期长达40周左右,孕妇出现不适症状是普遍的经历,但并非每个孕妇都要经历所有的不适,而且在不同孕期所出现的症状不同,个体所感受的程度也有明显差异。当症状不严重时,指导孕妇休息,使症状得到缓解,还可以采取各种预防措施避免症状的发生。同时在孕妇自身特殊的生理变化,     

环境线索对戒断期海洛因依赖者神经电生理的影响

Objective To explore the changes of craving and neuro-electrophysiological reactions under the exposure of heroin-related cues in abstinent heroin dependents.Methods In this self-controlled study,382 abstinent heroin dependent patients watched video of heroin smoking and injecting situations,and in the meantime were exposed to herein simulacrum and apparatus after relaxation exercises.The neuroelectrophysiological reactions were mcagured with a multi-biofeedback instrument before and after the cue exposed.Self-reported craving was also assessed before and after cue exposed.Results The craving were increased[(18±22)mm vs.(29±29)mm,P＜0.01]after cue exposures compared to pre-exposure,EMG[(12±7)μN vs.(14±10)μV,P＜0.01]and SC[(6.8±4.3)μS vs.(7.4±4.3)μS,P＜0.01]also increased.But the percentages of δ,θ,α,SMR,low β,high β decreased compared to that under the cue exposures[8:(10.8±4.7)%vs.(9.7±4.4)%,P＜0.01;0:(6.8±2.0)%vs.(6.3±2.0)%,P＜0.01;α:(4.8±1.8)%vs.(4.5±1.7)%,P＜0.01;SMR:(3.0 ±1.2)%vs.(2.8±1.2)%,P＜0.01;low β:(2.6±1.1)%vs.(2.5±1.1)%,P＜0.01 and high β:(4.6 ±1.5)%vs.(4.5±1.5)%.P＜0.05].Conclusions The results indicate that drug-related cue induce heroin craving and electrophysiological reactions.     

应用骨间背侧肌皮瓣修复手部创面

目的 报道应用骨间背侧肌肌皮瓣修复手部创面的临床疗效. 方法 2006年12月至2010年6月,以第1～3掌骨间背侧动脉走行体表投影为皮瓣的轴线,根据受区缺损面积大小及形状设计骨间背侧肌皮瓣修复手部创面缺损,修复掌指关节附近皮肤缺损、肌腱外露伴空腔形成8例,手背近腕背横纹皮肤缺损伴第2、3指背肌腱外露3例,中指近节指骨皮肤缺损伴肌腱及神经外露1例.缺损面积最小为1.5 cm×3.8 cm,最大为5.0 cm×6.0 cm.结果 皮瓣全部成活.术后经3个月～2年的随访,修复后的皮瓣质地、外形满意,手部关节屈伸功能不受限,活动自如,无手部功能障碍.皮瓣两点辨别觉为6～10 mm,感觉良好. 结论 应用骨间背侧肌肌皮瓣修复手部缺损创面解剖结构恒定,操作简便,皮瓣成活率高,适宜修复手部比较严重的软组织缺损.     

2864人胆囊壁胆固醇结晶自然转归初步观察

目的探讨胆囊壁胆固醇结晶的自然转归及与其他良性胆囊疾患的关系。方法对2009年7月始在我院进行体检的长兴县城镇居民2 864人进行2年的前瞻性观察,比较胆囊壁胆固醇结晶组与非结晶组并发其他胆囊良性疾患的差异,记录胆囊壁胆固醇结晶消失、新增、并发或转变为胆囊结石或胆囊息肉的人数,并进行比较。结果胆囊壁胆固醇结晶组并发胆囊炎的发病率明显高于非结晶组,有统计学差异(P<0.01),而并发胆囊结石或胆囊息肉的发病率与非结晶组无明显差别。随诊期间,结晶组胆固醇结晶自然消失114例(45.8%),结晶消失后未见有胆囊结石出现,9例(3.6%)转化为胆囊息肉样病变;结晶组另135例仍然发现有结晶,其中3例并发新的胆囊结石,2例并发新的胆囊息肉样病变;45例(18.1%)在随诊期间发作不同程度的胆囊炎,3例因并发急性胆囊炎或胆囊结石进行胆囊切除术,病理提示胆固醇沉着症。非结晶组有116例(4.44%)出现结晶,104例(4.0%)发作不同程度的胆囊炎,与结晶组比较有统计学差异(P<0.01)。结论胆囊壁胆固醇结晶可自然消失,结晶的持续存在可对胆囊壁造成损害,是胆囊炎发生的高危因素;胆囊壁胆固醇结晶与胆固醇沉着症存在关联,未发现与胆囊结石相关。     

深情缅怀谷铣之教授

中国现代放射肿瘤学奠基人之一,著名医学科学家、医学教育家,中国医学科学院北京协和医学院肿瘤医院首任放疗科主任,中华医学会放射肿瘤治疗学分会1～3届主任委员,《中华放射肿瘤学杂志》1～4届总编辑谷铣之教授,于2012年3月19日18时45分在北京因病逝世,享年94岁.     

环境线索对戒断期海洛因依赖者神经电生理的影响

Objective To explore the changes of craving and neuro-electrophysiological reactions under the exposure of heroin-related cues in abstinent heroin dependents.Methods In this self-controlled study,382 abstinent heroin dependent patients watched video of heroin smoking and injecting situations,and in the meantime were exposed to herein simulacrum and apparatus after relaxation exercises.The neuroelectrophysiological reactions were mcagured with a multi-biofeedback instrument before and after the cue exposed.Self-reported craving was also assessed before and after cue exposed.Results The craving were increased[(18±22)mm vs.(29±29)mm,P＜0.01]after cue exposures compared to pre-exposure,EMG[(12±7)μN vs.(14±10)μV,P＜0.01]and SC[(6.8±4.3)μS vs.(7.4±4.3)μS,P＜0.01]also increased.But the percentages of δ,θ,α,SMR,low β,high β decreased compared to that under the cue exposures[8:(10.8±4.7)%vs.(9.7±4.4)%,P＜0.01;0:(6.8±2.0)%vs.(6.3±2.0)%,P＜0.01;α:(4.8±1.8)%vs.(4.5±1.7)%,P＜0.01;SMR:(3.0 ±1.2)%vs.(2.8±1.2)%,P＜0.01;low β:(2.6±1.1)%vs.(2.5±1.1)%,P＜0.01 and high β:(4.6 ±1.5)%vs.(4.5±1.5)%.P＜0.05].Conclusions The results indicate that drug-related cue induce heroin craving and electrophysiological reactions.     

胃癌B超误诊胃平滑肌瘤1例

患者,男性,50岁。主诉:上腹部不适,食欲减退。左上腹发现包块一月余。体检:心肺(一),肝、脾未及,左上腹可扪及5cm×6cm肿物,质韧、活动可。电子胃镜检查:胃底、胃体未见异常,窦部胃腔狭窄,内镜通过困难,但胃粘膜光滑,取胃粘膜活检未见异常。要求超声会诊。B超所见:饮水600ml,胃底、胃     

环境线索对戒断期海洛因依赖者神经电生理的影响

Objective To explore the changes of craving and neuro-electrophysiological reactions under the exposure of heroin-related cues in abstinent heroin dependents.Methods In this self-controlled study,382 abstinent heroin dependent patients watched video of heroin smoking and injecting situations,and in the meantime were exposed to herein simulacrum and apparatus after relaxation exercises.The neuroelectrophysiological reactions were mcagured with a multi-biofeedback instrument before and after the cue exposed.Self-reported craving was also assessed before and after cue exposed.Results The craving were increased[(18±22)mm vs.(29±29)mm,P＜0.01]after cue exposures compared to pre-exposure,EMG[(12±7)μN vs.(14±10)μV,P＜0.01]and SC[(6.8±4.3)μS vs.(7.4±4.3)μS,P＜0.01]also increased.But the percentages of δ,θ,α,SMR,low β,high β decreased compared to that under the cue exposures[8:(10.8±4.7)%vs.(9.7±4.4)%,P＜0.01;0:(6.8±2.0)%vs.(6.3±2.0)%,P＜0.01;α:(4.8±1.8)%vs.(4.5±1.7)%,P＜0.01;SMR:(3.0 ±1.2)%vs.(2.8±1.2)%,P＜0.01;low β:(2.6±1.1)%vs.(2.5±1.1)%,P＜0.01 and high β:(4.6 ±1.5)%vs.(4.5±1.5)%.P＜0.05].Conclusions The results indicate that drug-related cue induce heroin craving and electrophysiological reactions.