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71.
New method of sentinel node identification with ultrasonography using albumin as contrast agent: a study in pigs 总被引:2,自引:0,他引:2
Omoto K Mizunuma H Ogura S Hozumi Y Nagai H Taniguchi N Itoh K 《Ultrasound in medicine & biology》2002,28(9):1115-1122
The purpose of our study was to verify in animals the possibility of using albumin-enhanced ultrasonography as a modality for sentinel node detection. The nine pigs were injected subcutaneously in the neck with albumin, five with 5% solution and four with 25% solution, and then the regional lymph nodes were observed over time. It was found that, where the 5% solution had been injected, the lymph nodes showed no change, but where the 25% solution had been used, a high echo 1 to 5 mm in size was seen at the hilus of the nearest lymph node. Examination of the excised pathologic specimens of lymph nodes demonstrated that this echo was due to albumin accumulated in the efferent lymphatics. This finding suggested that this technique of ultrasonography using albumin as a contrast agent was an effective new method of identifying sentinel nodes. 相似文献
72.
Haosheng Mu Shinji Otani Mikizo Okamoto Yae Yokoyama Yasuko Tokushima Kazunari Onishi Takenobu Hosoda Youichi Kurozawa 《Yonago acta medica》2014,57(4):133-136
Background
The air quality index (AQI) is widely used to characterize the quality of ambient air. Chinese cities officially report the AQI on a daily basis. To assess the possible effects of air pollution on daily outpatient visits, we examined the association between AQI and the daily outpatient count.Methods
Daily data on outpatient visits to each clinical department were collected from the Z county hospital of Datong City, China. The collection period was between 5 April and 30 June, 2012. Daily AQI data and meteorological information were simultaneously recorded. We compared outpatient counts between the index days and comparison days, and calculated Pearson’s product moment correlation coefficient between outpatient counts and AQI levels.Results
The average AQI level for index days was significantly higher than that for comparison days. No significant difference was observed in temperature or relative humidity between index days and comparison days. The outpatient counts for pediatrics were significantly higher on index days than on comparison days, and no significant difference was noted in other clinical departments. The outpatient counts for pediatrics positively correlated with the AQI level, and no correlation was noted in other clinical departments.Conclusion
The present study assessed the association between daily outpatient visits and air pollution using AQI. The results obtained suggest that air pollution could increase the outpatient count for pediatrics. 相似文献73.
Youichi Nakagawa Katsuhiko Sannomiya Makiko Kinoshita Tsutomu Shiomi Kouhei Okada Hisayo Yokoyama Yukiko Sawaguti Keiko Minamoto Chang-nian Wei Shoko Ohmori Susumu Watanabe Koichi Harada Atsushi Ueda 《Environmental health and preventive medicine》2008,13(3):138-147
Objective We conducted a study to develop an assessment sheet for fall prediction in stroke inpatients that is handy and reliable to
help ward staff to devise a fall prevention strategy for each inpatient immediately upon admission.
Methods The study consisted of three steps: (1) developing a data sampling form to record variables related to risk of falls in stroke
inpatients and conducting a follow-up survey for stroke inpatients from their admission to discharge by using the form; (2)
carrying out analyses of characteristics of the present subjects and selecting variables showing a high hazard ratio (HR)
for falls using the Cox regression analysis; (3) developing an assessment sheet for fall prediction involving variables giving
the integral coefficient for each variable in accordance with the HR determined in the second step.
Results and discussion (1) Subjects of the present survey were 704 inpatients from 17 hospitals including 270 fallers. (2) We selected seven variables
as predictors of the first fall: central paralysis, history of previous falls, use of psychotropic medicines, visual impairment,
urinary incontinence, mode of locomotion and cognitive impairment. (3) We made 960 trial models in combination with possible
coefficients for each variable, and among them we finally selected the most suitable model giving coefficient number 1 to
each variable except mode of locomotion, which was given 1 or 2. The area under the ROC curve of the selected model was 0.73,
and sensitivity and specificity were 0.70 and 0.69, respectively (4/5 at the cut-off point). Scores calculated from the assessment
sheets of the present subjects by adding coefficients of each variable showed normal distribution and a significantly higher
mean score in fallers (4.94 ± 1.29) than in non-fallers (3.65 ± 1.58) (P = 0.001). The value of the Barthel Index as the index of ADL of each subject was indicated to be in proportion to the assessment
score of each subject.
Conclusion We developed an assessment sheet for fall prediction in stroke inpatients that was shown to be available and valid to screen
inpatients with risk of falls immediately upon admission. 相似文献
74.
Nobutada Tachi M.D. Shuji Wakai M.D. Yukie Watanabe M.D. Youichi Kurosawa M.D. Yoshitaka Agatsuma M.D. Shunzo Chiba M.D. 《Pediatrics international》1992,34(2):139-143
The histological and histochemical findings in the respiratory muscles of a patient with severe neonatal nemaline myopathy are described. The patient suffered from frequent pneumonia associated with vomiting due to gastroesophageal reflux and died at 3 months from respiratory failure. The diaphragm was moderately involved and the intercostal muscles mildly involved. Core/targetoid structures were observed in the diaphragm and intercostal muscles. 相似文献
75.
Richard Reid MD Katherine H. Omoto MS Sheryl L. Precop RN NP Nancy R. Berman RN CS MSN Lisa H. Rutledge BA Steven M. Dean MD Mark Pleatment MD 《American journal of obstetrics and gynecology》1995,172(6):1684-1701
Objective: The management of chronic vulvovaginal pain, not explicable on specific histologic grounds, presents a major problem in referral centers for lower genital tract diseases.Study design: This article reports on a two-step protocol in a sample of 175 medical nonresponders, drawn from a 2-year cohort of 725 women with vulvovaginal pain. The first maneuver was the use of a flashlamp-excited dye laser to selectively photocoagulate symptomatic subepithelial blood vessels in 168 women; the second was the microsurgical removal of chronically painful Bartholin's glands in 52 women not responsive or not suited to flashlamp-excited dye laser photothermolysis.Results: Dye laser response rates werer independent of whether patients manifested macroscopic focl of painful erythema (“vestibular adenitis”) or just colposcopically apparent hyperemia-ectasia of the individual blood vessels (“pruritic papillomatosis”) (55% vs 45% after a single surgical procedure; 76% vs 65% after serial retreatment; p not significant). Conversely, response rates were much lower among women in whom pressure on the Bartholin's glands produced sharp, lancinating pain (15% vs 66% after a single surgical procedure; 22% vs 93% after serial retreatment; p < 0.001). Forty-two (85%) of 50 patients with flashlamp-excited dye laser failure had deep pain; however, the impasse to progress was broken by gland removal. Final response rates were 92.5% (complete response 62%; partial response 30%) in the “surface-only” group and 80.3% in the “surface-plus-deep” group (χ2 = 14.9; p < 0.001). The major complication was acute bacterial cellulitis, occurring in the first postoperative week. Modification of the treatment protocol to include topical antibiotics with an occlusive dressing reduced the cellulitis rate from 17.2% to 2.5%. In four women (1.8%) Koebner-like exophytic condylomas also developed within 1 month of flashlamp-excited dye laser surgery.Conclusion: The availability of a safe, efficacious, and relatively noninvasive treatment should reduce the need for resective surgery in most patients with idiopathic vulvodynia. 1995; 172; 1684–1701.) 相似文献
76.
77.
78.
Kurozawa Y Nasu Y Hosoda T Nose T 《Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine》2002,44(12):1203-1206
The prognosis of vibration-induced white finger was investigated with a long follow-up period. From 1975 to 1994, 99 men with hand-arm vibration syndrome who received the annual compulsory examination at San-in Rosai Hospital were followed up for 15 years or longer. Based on the extent of finger-blanching attacks described in the medical records, they were classified according to the vascular stage of the Stockholm workshop scale. In our laboratory, finger systolic blood pressure (FSBP) measurement after finger cooling has been performed since 1989. We compared the stage classification with the results of FSBP measurement after finger cooling in the period 1989-1994. The stage 2 and stage 3 groups showed a significant decrease in FSBP% compared with the stage 0 group. The vascular stage classification based on subjective symptoms in this study was to a certain extent reliable. Although vibration-induced white finger symptoms tended to improve to some extent, 43.2% and 70.4% of patients with stage 2 and stage 3 at first examination, respectively, still suffered from finger blanching attacks after 15 years of observation. Blanching of fingers in advanced stages, especially stage 3, was found to be persistent many years after cessation of vibration exposure. 相似文献
79.
We investigated the specificity of obtained antisera to beta-methyldigoxin by the enzyme immunoassay. Three types of hapten-bovine serum albumin (BSA) conjugates were synthesized to obtain high specific antisera to beta-methyldigoxin. The haptens were linked to the carrier protein through hemisuccinate at C-3' and C-3' positions in the digitoxose chain and at C-12 position in the aglycone. Anti-beta-methyldigoxin 3'-hemisuccinate-BSA antiserum showed a low detection limit (0.2 ng/ml) and possessed high specificity for beta-methyldigoxin, exhibiting low cross-reactions with digoxigenin bisdigitoxoside (8.3%), dihydrodigoxin (4.8%), digitoxin (1.5%), and digoxigenin monodigitoxoside (0.95%), except for cross-reaction with digoxin (43%). Compared with commercial antidigoxin antiserum, clinically used to monitor beta-methyldigoxin concentration in human serum, cross-reaction data of anti-beta-methyldigoxin 3'-hemisuccinate-BSA antiserum showed higher specificity for beta-methyldigoxin. The intra-assay and inter-assay variations using this antiserum were less than 6.9% and 8.1%, respectively. The recovery tests were good, within the range of 96.2-104.3%. Phenyl boric acid (PBA) column treatment was effective to rapidly and selectively separate beta-methyldigoxin from the mixture of beta-methyldigoxin and its metabolites in human serum. The recovery tests of beta-methyldigoxin with PBA column in human serum were about 110% and interference of metabolites of beta-methyldigoxin was negligible. These results suggest that anti-beta-methyldigoxin 3'-hemisuccinate-BSA antiserum and PBA column treatment are useful to more precisely monitor the unchanged type of beta-methyldigoxin concentration in human serum. 相似文献
80.
STR/N, an inbred strain of mice, is known to exhibit extreme polydipsia and polyuria. The objective of this study was to investigate the possible reasons for polydipsia. First, comparisons were made between STR/N mice and control mice from the Institute of Cancer Research (ICR) concerning daily drinking, urinary excretion, and basal cardiovascular function. Then, since angiotensin II (ANG II) is a potent stimulus for drinking behavior, we investigated the effects of intracerebroventricular (i.c.v.) administration of ANG II on cardiovascular and water intake responses. Daily water intake, food intake, urinary volume, and urinary electrolytes (Na and K) excretion were larger in STR/N mice than in ICR mice, and the basal blood pressure was significantly lower in STR/N mice than in ICR mice. The i.c.v. administration of ANG II (10 pmol/per mouse) resulted in increased mean arterial blood pressure (MAP) and water intake in both STR/N and ICR mice, but the changes in MAP were significantly larger in STR/N mice than in ICR mice. These results suggest that polydipsia in STR/N mice is at least partially attributable to high sensitivity of central ANG II receptors and low MAP. 相似文献