全文获取类型
收费全文 | 24954篇 |
免费 | 1582篇 |
国内免费 | 389篇 |
专业分类
耳鼻咽喉 | 571篇 |
儿科学 | 304篇 |
妇产科学 | 260篇 |
基础医学 | 4100篇 |
口腔科学 | 456篇 |
临床医学 | 2086篇 |
内科学 | 4829篇 |
皮肤病学 | 847篇 |
神经病学 | 1651篇 |
特种医学 | 1486篇 |
外国民族医学 | 3篇 |
外科学 | 3382篇 |
综合类 | 274篇 |
一般理论 | 9篇 |
预防医学 | 895篇 |
眼科学 | 744篇 |
药学 | 2491篇 |
3篇 | |
中国医学 | 430篇 |
肿瘤学 | 2104篇 |
出版年
2024年 | 15篇 |
2023年 | 138篇 |
2022年 | 658篇 |
2021年 | 963篇 |
2020年 | 497篇 |
2019年 | 651篇 |
2018年 | 819篇 |
2017年 | 654篇 |
2016年 | 893篇 |
2015年 | 1350篇 |
2014年 | 1590篇 |
2013年 | 1699篇 |
2012年 | 2504篇 |
2011年 | 2325篇 |
2010年 | 1415篇 |
2009年 | 1199篇 |
2008年 | 1553篇 |
2007年 | 1465篇 |
2006年 | 1259篇 |
2005年 | 1136篇 |
2004年 | 877篇 |
2003年 | 725篇 |
2002年 | 634篇 |
2001年 | 364篇 |
2000年 | 311篇 |
1999年 | 274篇 |
1998年 | 118篇 |
1997年 | 108篇 |
1996年 | 60篇 |
1995年 | 55篇 |
1994年 | 56篇 |
1993年 | 50篇 |
1992年 | 73篇 |
1991年 | 61篇 |
1990年 | 47篇 |
1989年 | 45篇 |
1988年 | 27篇 |
1987年 | 36篇 |
1986年 | 32篇 |
1985年 | 24篇 |
1984年 | 20篇 |
1983年 | 22篇 |
1982年 | 12篇 |
1981年 | 16篇 |
1979年 | 17篇 |
1978年 | 10篇 |
1977年 | 9篇 |
1976年 | 9篇 |
1974年 | 8篇 |
1973年 | 8篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
71.
72.
Sang Rae LEE D. D. S. 《Oral Radiology》1986,2(1):83-89
Summary Three cases of the ameloblastoma, located periapically and interradicularly, which have similar radiographic appearances to
odontogenic cysts are described.
The ameloblastoma is locally invasive, rearely metastatic, and has a much higher recurrence rate than the odontogenic cysts
after surgical intervention, nevertheless, it is classified as a benign odontogenic tumor of the jaws.
In order to collect appropriate information for the diagnosis of an ameloblastoma which requires differentiation from odontogenic
cyst, there are two basic categories we should observe. One is the clinical manifestations including age, history, signs and
symptoms of the patient. The other is the radiographic pattern and configuration including location, size, shape, radiolucency,
periphery, bony expansion, and relationship to the adjacent anatomic landmarks.
On the basis of these considerations, it is of significant importance to provide an appropriate diagnosis derived from the
differential diagnosis for guidance to a corresponding and successful surgical procedure. 相似文献
73.
Summary. Because of the belief that post-operative deep vein thrombosis (DVT) is rare in Asian patients, thromboprophylaxis is not
usually prescribed for surgical patients. This study reports an open multi-centre controlled study of the use of a low molecular
weight heparin, nadroparin calcium (Fraxoparine Sanofi France), as opposed to no prophylaxis in 100 patients undergoing uncemented
total hip replacement. The patients had bilateral venography performed preoperatively and 10 days after operation. Eight patients
(16%) developed DVT in the control group of 50 patients and 1 (2%) in the treatment group, also of 50 patients. Pulmonary
embolus occurred in 1 patient in the treatment group and in 3 in the control group. Intraoperative and postoperative blood
loss did not differ significantly between the two groups. Our study suggests that the incidence of DVT in Asian patients,
though somewhat less than in their Western counterparts, is still considerable. It confirms the safety and efficacy of nadroparin
calcium in preventing post-operative DVT in patients undergoing elective total hip replacement.
Accepted: 19 March 1997 相似文献
Résumé. A cause de l’idée selon laquelle la thrombose veineuse profonde post-opéraloire est rare parmi les patients asiatiques, la tromboprophylaxie pour les patients opérés est inhabituelle. Nous avons accompli une étude, comparant la prophylaxie au moyen d’héparine de bas poids moléculaire en utilisant du calcium nadroparine (Fraxiparine Sanofi France) et la non-prophylaxie sur 100 patients subissant un remplacement total de la hanche. Les patients ont subi une vénographie bilatérale avant l’opération et 10 jours après. Huit patients (16%) ont développé une thrombose veineuse dans le groupe de contr?le, contre 1 (2%) dans le groupe traité (p = 0.015, 95% CI 0.02 – 0.67). Trois embolies pulmonaires sont survenues dans le groupe de contr?le et 1 dans le groupe traité (p = 0.27 95% CI 0.04 – 2.44) aucune n’étant fatale. La perte de sang intra-opératoire et post-opératoire n’a pas varié de manière significative entre les deux groupes. Notre étude démontre que l’incidence de la thrombose veineuse profonde post-opératoire chez les patients asiatiques est notable bien qu’elle soit moindre que dans les pays occidentaux et confirme la s?reté et l’efficacité du calcium nadroparine pour la prévenir aprés un remplacement total de la hanche.
Accepted: 19 March 1997 相似文献
74.
目的 基于倾向性评分逆处理概率加权(IPTW)法评估EB病毒(EBV)在结外NK/T细胞淋巴瘤患者中的预后价值。方法 收集2012年10月—2021年4月淮海淋巴瘤协作组中8家医疗机构初诊为结外NK/T细胞淋巴瘤且具有全血EBV-DNA数据的468例患者的临床资料。采用IPTW法分析EBV载量对结外NK/T细胞淋巴瘤患者生存期的影响;采用Cox比例风险模型进行多因素分析;绘制Kaplan-Meier曲线,组间比较采用Log rank χ2检验。结果 468例结外NK/T细胞淋巴瘤患者中,EBV-DNA阳性266例,EBV-DNA阴性202例。EBV-DNA阳性组和阴性组患者的5年OS分别为62.5%和89.2%,两组比较,经Log rank χ2检验,差异有统计学意义(χ2=42.900,P=0.000)。IPTW前,两组的美国东部肿瘤协作组(ECOG)活动状态(PS)评分(ECOG PS评分)、原发部位、CA分期、Ann Arbor分期、白蛋白、乳酸脱氢酶、治疗方案比较,差异均有统计学意义(P<0.05)。IPT... 相似文献
75.
Immunochemical characterization of cytochrome P-450 isozymes responsible for benzene oxidation in the rat liver 总被引:4,自引:0,他引:4
Nakajima Tamie; Elovaara Eivor; Park Sang S.; Gelboin Harry V.; Hietanen Eino; Vainio Hani 《Carcinogenesis》1989,10(9):1713-1717
The contribution of cytochrome P-450 isozymes to benzene metabolismin liver microsomes from fed, fasted, pyrazole-, pbenobarbital(PB)- and ethanol-treated rats and in respective isocaloriccontrols was investigated using monoclonal antibodies (mAbs).Clone 1-7-1 mAb did not inhibit benzene metabolism, whereasclone 2-66-3 inhibited only in PB-induced microsomes at a highconcentration of benzene (6.26 mM), and clone 1-91-3 mAb inhibitedbenzene metabolism in all cases. The degree of inhibition wasas follows: fed isocaloric control PB < fasted < pyrazole ethanol. The pattern of inhibition was similar with clone 1-91-3for low (0.23 mM) and high concentrations of benzene, exceptin PB-induced mkrosomes. Western blot analysis showed that clone1-7-1 mAb did not bind any liver mkrosomal protein in the regionof cytochrome P-450s, whereas with clone 2-66-3 a clear-cutband was seen only in liver microsomes from PB-treated rats,with clone 1-98-1, a band was detected in mkrosomes from alltreated groups, in the following order: PB = isocaloric control< fed < fasted < pyrazole < ethanol. These resultsindicate that (i) cytochromes P-450b,e and P-450J contributeto benzene metabolism in rat liver; (ii) the former has a lowaffinity to benzene and is induced by PB; and (iii) P-450J hasa high affinity to benzene and is induced by 1-day fasting,pyrazole and ethanol, but decreased by PB treatment. 相似文献
76.
Multiplex PCR for the detection of genes encoding aminoglycoside modifying enzymes and methicillin resistance among Staphylococcus species 总被引:4,自引:0,他引:4
Choi SM Kim SH Kim HJ Lee DG Choi JH Yoo JH Kang JH Shin WS Kang MW 《Journal of Korean medical science》2003,18(5):631-636
We developed multiplex polymerase chain reaction (PCR) to detect aac(6 ')/aph(2 "), aph(3 ')-IIIa, and ant(4 ')-Ia, the genes encoding the most clinically relevant amino-glycoside modifying enzymes (AME), and simultaneously, the methicillin resistant gene, mecA, in Staphylococcus species. Clinical isolates of 45 S. aureus and 47 coagulase negative staphylococci (CNS) from tertiary university hospitals were tested by conventional susceptibility testing, using the agar dilution method and by multiplex PCR. Of a total of 92 isolates, 61 isolates were found to be methicillin-resistant. Of these, 54 isolates (89%) were found to be harboring mecA. Seventy-five percent of the 92 isolates demonstrated resistance to at least one of the aminoglycosides tested. Moreover, resistance to aminoglycosides was closely associated with methicillin-resistance (p<0.05). The most prevalent AME gene was aac(6 ')/aph(2 ") which was found in 65% of the isolates, and ant(4 ')-Ia and aph(3 ')-IIIa were present in 41% and 9% of the isolates, respectively. The concordance between methicillin-resistance and the presence of mecA gene was 98% in S. aureus and 81% in CNS. The concordance between gentamicin resistance and the presence of aac(6 ')/aph(2 ") gene was 100% in S. aureus and 85% in CNS. The multiplex PCR method that we developed appears to be both a more rapid and reliable than conventional method. 相似文献
77.
Overexpression of S100A4 is closely related to the aggressiveness of gastric cancer 总被引:25,自引:0,他引:25
Cho YG Nam SW Kim TY Kim YS Kim CJ Park JY Lee JH Kim HS Lee JW Park CH Song YH Lee SH Yoo NJ Lee JY Park WS 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2003,111(5):539-545
Elevated levels of the calcium-binding protein S100A4 cause metastasis of benign rat mammary tumor cells. To investigate whether S100A4 plays an important role in the invasion and metastasis of gastric cancers, we examined the gene mutations in the coding regions and expression patterns of the S100A4 in gastric adenocarcinoma in Korea. Moderate to strong expression of S100A4 was found in 53 (68.8%) of the 77 gastric adenocarcinomas, whilst normal gastric epithelium either failed to stain or showed weak staining. Interestingly, S100A4 expression was more frequently observed in gastric cancer patients with advanced gastric cancer (p=0.039), positive lymph node metastasis (p=0.001), and peritoneal dissemination (p=0.022). No gene mutations were found in the analyzed genomic area in 77 gastric adenocarcinomas and 15 gastric cancer cell lines. We found one single nucleotide polymorphism without an amino acid change, A99G, in two cases. These data suggest that the overexpression of S100A4 may be closely related to the aggressiveness of gastric cancer in Korea. 相似文献
78.
Kouda K Nakamura H Kohno H Ha-Kawa SK Tokunaga R Sawada S 《Mechanisms of ageing and development》2004,125(5):375-380
Dietary restriction (DR) is known to prolong life in laboratory animals. Intermittent (alternate-day) fasting or short-term repeated fasting has also been reported to increase the life span of animals. In the present study, we investigated the changes or induction of abnormalities of protein metabolism in rats during fasting, and measured asialoglycoprotein uptake and cell death/proliferation in the liver of rats receiving fasting and refeeding. In the results, liver weight decreased significantly after 48 h of fasting and increased during the refeeding period, returning to the pre-fasting level by 12 h of refeeding. Cell death, determined by single stranded DNA (ssDNA) staining method, increased during the fasting period, and returned to the pre-fasting level during the refeeding period. Cell proliferation, determined using antibodies (Ab) against proliferating cell nuclear antigen, decreased during the fasting period, and increased during the refeeding period. Changes in cell death and cell proliferation were inversely related. However, there was no significant difference in asialoglycoprotein uptake by the whole liver between the ad libitum (AL)-fed rats and 48 h fasted rats. Thus, neither the changes in liver weight nor cell death/proliferation affected asialoglycoprotein uptake on a living body. These results suggest that episodes of 48 h fasting do not induce protein metabolism abnormalities in the liver. 相似文献
79.
Oh SH Kim JK Song KS Noh SM Ghil SH Yuk SH Lee JH 《Journal of biomedical materials research. Part A》2005,72(3):306-316
Sol-gel transition temperature-controllable Pluronic F127/F68 mixtures including mildly crosslinked alginate and nonsteroidal anti-inflammatory drug (ibuprofen) were prepared to evaluate their potential as tissue adhesion barrier gels. The sol-gel transition temperatures of the Pluronic mixtures could be controlled by adjusting F127/F68 ratio and polymer concentration. The mildly crosslinked alginate with still flow property provided the residence stability of Pluronic mixture gels in the body. Ibuprofen was loaded in Pluronic mixtures to reduce inflammatory response in the body and, thus, to prevent tissue adhesion. The gelation temperatures of the Pluronic mixtures were not affected by the alginate but lowered by the addition of ibuprofen. The in vitro drug release behavior and in vivo peritoneal tissue adhesion of the Pluronic mixtures with the sol-gel transition just below body temperatures were investigated. The drug release behavior from the ibuprofen (1 wt%)-loaded Pluronic mixture gels at 37 degrees C was examined using a membrane-less dissolution model. The drug in the mixture gels was released continuously up to about 45-65% of the total loading amount during the first 7 days. For in vivo evaluation of tissue anti-adhesion potential, the Pluronic mixtures with/without drug were coated on the peritoneal wall defects of rats and their tissue adhesion extents and tissue reactions (inflammatory response, granulation tissue formation, and toxicity in organs) were compared. It was observed that ibuprofen has a positive effect for the peritoneal tissue anti-adhesion. The Pluronic F127/F68/alginate/ibuprofen mixture gel (25 wt% of F127/F68 [7/3], 1 wt% ibuprofen) was highly effective for the prevention of peritoneal tissue adhesion and showed a relatively low inflammatory response and non-toxicity, and thus can be a good candidate material as a coatable or injectable tissue adhesion barrier gel. 相似文献
80.
The novel cytokine p43 stimulates dermal fibroblast proliferation and wound repair 总被引:3,自引:0,他引:3
下载免费PDF全文
![点击此处可从《The American journal of pathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Park SG Shin H Shin YK Lee Y Choi EC Park BJ Kim S 《The American journal of pathology》2005,166(2):387-398
The multifunctional cytokine p43 acts on endothelial and immune cells to control angiogenesis and inflammation. In this report, we describe an additional activity of p43 that specifically promotes fibroblast proliferation and wound repair. In skin wound regions from mice, tumor necrosis factor-alpha induced p43 expression and secretion from macrophages recruited to the site. p43 also promoted fibroblast proliferation through its 146-amino acid N-terminal domain as revealed by deletion mapping. This p43-induced fibroblast proliferation was mediated by extracellular signal-regulated kinase (Erk). Depletion of endogenous p43 in mice by gene disruption retarded wound repair, whereas exogenous supplementation of recombinant human p43 to the wound area stimulated dermal fibroblast proliferation, collagen production, and wound closure. Thus, we have identified a novel p43 activity involving the stimulation of fibroblast proliferation, which could be applied therapeutically to aid wound repair. 相似文献