开放实验室的初步探讨

开放实验室是近年来高校实验教学改革的新举措,本文从管理的角度阐述了开放实验室在实验教学改革中对培养学生的实践能力、创新意识、个性化发展等方面发挥的重要作用。从实验时间、实验内容以及仪器设备共享等方面进行了重点讨论。     

BorrmannⅣ型胃癌的临床特征和外科治疗

目的探讨BorrmannⅣ型胃癌的临床特征和治疗方法。方法回顾性总结29例BorrmannⅣ型胃癌的临床资料,分析本型胃癌的临床表现、病理特点以及手术治疗的特殊性。结果全部患者均有上腹饱胀、隐痛不适、食欲不振,同时伴有明显的进行性消瘦,短期内体重明显减轻等临床症状。术前病理确诊为本型胃癌者24例。5例患者胃镜诊断为浅表型胃炎。获根治性切除22例,姑息性远侧胃切除者3例,放弃手术者4例。其1、2、3年生存率分别为38.9%、8.3%、0%。结论(1)BorrmannⅣ型胃癌是一种恶性程度极高的胃癌,其具有独特的生物学特性,治疗效果差,生存期短,预后不佳。(2)对BorrmannⅣ型胃癌应强调以根治性全胃切除和联合脏器切除为主的综合治疗方法。     

大鼠下丘脑室旁核及其邻近区域至室管膜的传出联系

用20只Wistar大鼠以PHA—L免疫组织化学顺行追踪技术研究了下丘脑室旁核及其邻近区域对脑室系统室管膜的传出联系。在脑室系统某些部位的室管膜层或其下方见有丰富的标记纤维并见许多膨结和终末膨突。这些纤维似乎参与形成室管膜上、下丛,构成脑—脑脊液神经体液回路的重要环节。     

用稳定性同位素~(58)Fe中子活化法测定缺铁性贫血儿童膳食铁吸收率

本文报告了应用稳定性同位素~(58)Fe对三组缺铁性贫血儿童,分别摄取平衡膳、平衡膳加大豆蛋白膳和平衡膳加大豆蛋白加维生素C膳时,各组儿童膳食铁的吸收率。测定结果顺次分别为12.0±3.6％、10.7±4.7％和18.1±3.6％。后者高于前二者,差异显著。据此,作者同意国际营养性贫血咨询小组(INACG)以及大多数学者的主张,即大豆制品不利于或降低膳食铁的生物利用率(bioavailability)。本文并结合实验讨论了本法的原理、操作技术及误差控制等问题,评价了本法在类似工作中的重要意义。     

脊麻药复合微量芬太尼对防治牵拉反应的探讨

目的 探讨脊麻药中复合微量芬太尼对牵拉反应的防治效果。方法 选择美国麻醉医师协会（american society of anesthesiologists，AsA）Ⅰ-Ⅱ级、足月、初产及单胎而需行剖宫产术的病人60例，随机分成2组，每组30例。2组病人的年龄、性剐、体重、局麻药用量、麻醉方法均无显著性差异，均选用腰硬联合麻醉（combined spinal—epidural anesthesia，CSEA）。A组：等比重0．5％罗哌卡因9-11mg＋芬太尼10μg。B组：等比重0．5％罗哌卡因9-11mg。观察术中牵拉反应和生命体征并记录，进行统计学处理。结果 2组间麻醉前、后相对应的MAP（平均动脉压）、HR（心率）、RR（呼吸频率）和SpO2（血氧饱和度）变化均无显著性差异（JP〉0．05），2组间新生儿Apgar评分均无显著性差异（P〉0．05），比较2组术中的牵拉反应，A组明显优于B组，有显著性差异（P〈0．05）结论 脊麻药中加入微量芬太尼对牵拉反应有良好的防治效果。     

Residual tactile sensitivity with self-directed stimulation in hemianaesthesia.

A case of hemianaesthesia caused by right hemisphere stroke was found to have good sensitivity and cutaneous localisation when she touched her impaired hand with her good contralateral hand or with a probe held by that hand. The capacity did not depend solely upon movement or positioning of her right arm, and she could also discriminate whether her own left fingers, as opposed to someone else's inter-digitated fingers, were being touched, but only when she did the touching. Thus, the threshold of the impaired hand appeared to be markedly affected by active involvement of the contralateral limb in delivering the stimulus.     

ROLE OF f3-RECEPTOR IN THE RADIX ANGELICAE SINENSIS ATTENUATED HYPOXIC PULMONARY HYPERTENSJON IN RATS

Acute pulmonary hypertension was caused by inhalation of 5% 02 in rats. Pulmonary vascujar re- sistance (PVR) increased, but heart rate (HR), cardiac output (CO) and carotid arterial pressure (CAP) were not obviously changed. After an intravenous admini- stration of Radix Angelicae sinensis, the acute pulmonary hypertension induced by inhalation of 5% O2 could be attenuated, but this effect disappeared if propranolol was given before Radix Angelicae sinensis. In chronic experiments, the same results were obtained, but the protective effect of Radix Angelicae sinensis on heart function was not influenced by propranolol. It is suggested that Radix Angelicae sinensis rmght play a role by stimulating the βz-receptor in the prevention of acute and chronic hypoxic pulmonary hypertension. However, prevention of hypertrophy of the right ventricle and enhancement of heart function in chronic hypoxic rats might not be attributed to the β1 receptor in the heart.     

维生素B_(12)注射液稳定性的研究

作者用恒温加速试验法研究了维生素B_(12)注射液的稳定性。结果表明:该注射液的稳定性在pH值4.80左右较好,加络合剂可增加其稳定性,有效期为5年。