全文获取类型
收费全文 | 410484篇 |
免费 | 73809篇 |
国内免费 | 25135篇 |
专业分类
耳鼻咽喉 | 4103篇 |
儿科学 | 8067篇 |
妇产科学 | 4316篇 |
基础医学 | 53143篇 |
口腔科学 | 10338篇 |
临床医学 | 60493篇 |
内科学 | 67948篇 |
皮肤病学 | 10419篇 |
神经病学 | 29537篇 |
特种医学 | 13971篇 |
外国民族医学 | 210篇 |
外科学 | 42687篇 |
综合类 | 63186篇 |
现状与发展 | 93篇 |
一般理论 | 51篇 |
预防医学 | 28515篇 |
眼科学 | 11150篇 |
药学 | 42914篇 |
451篇 | |
中国医学 | 23487篇 |
肿瘤学 | 34349篇 |
出版年
2024年 | 1273篇 |
2023年 | 5474篇 |
2022年 | 14099篇 |
2021年 | 18766篇 |
2020年 | 18257篇 |
2019年 | 21337篇 |
2018年 | 21309篇 |
2017年 | 21827篇 |
2016年 | 21672篇 |
2015年 | 26842篇 |
2014年 | 30422篇 |
2013年 | 29100篇 |
2012年 | 29427篇 |
2011年 | 32456篇 |
2010年 | 27253篇 |
2009年 | 19987篇 |
2008年 | 20644篇 |
2007年 | 19492篇 |
2006年 | 19162篇 |
2005年 | 18243篇 |
2004年 | 11696篇 |
2003年 | 11017篇 |
2002年 | 9282篇 |
2001年 | 8249篇 |
2000年 | 8412篇 |
1999年 | 8227篇 |
1998年 | 5138篇 |
1997年 | 5187篇 |
1996年 | 4015篇 |
1995年 | 3772篇 |
1994年 | 3159篇 |
1993年 | 2117篇 |
1992年 | 2323篇 |
1991年 | 1948篇 |
1990年 | 1658篇 |
1989年 | 1426篇 |
1988年 | 1208篇 |
1987年 | 1048篇 |
1986年 | 786篇 |
1985年 | 641篇 |
1984年 | 367篇 |
1983年 | 224篇 |
1982年 | 125篇 |
1981年 | 140篇 |
1980年 | 88篇 |
1979年 | 94篇 |
1977年 | 6篇 |
1974年 | 5篇 |
1972年 | 6篇 |
1971年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
71.
72.
目前新型冠状病毒肺炎(COVID-19)疫情在全球蔓延,形势严峻,并对全球公共卫生事业构成巨大挑战,快速准确的诊断COVID-19对疫情的防控有重要意义。本文报道1例COVID-19患者的调查和确诊过程,以对COVID-19确诊和疫情防控提供有价值的参考。患者为赴渝务工于2020年1月23日返乡人员,在渝期间,其同工地的一同事确诊为COVID-19,之后该工地接连有另外8位同事被确诊。患者返乡后2月2日被当地疫情防控单位采取医学隔离。患者于隔离后不久出现咳嗽,阵发性,干咳为主,偶可咳出黄色痰液等COVID-19相关临床症状,遂被当地新型冠状病毒肺炎定点医疗单位收治,后经市级新型冠状病毒肺炎诊治专家组远程视频会诊转入四川大学华西医院资阳医院。患者先后经历9次核酸检测,在前8次核酸检测均为阴性的情况下,于第9次核酸检测结果为阳性,2月21日最终确诊为新型冠状病毒肺炎。 相似文献
73.
L.‐Q. Zheng X.‐C. Han Y. Huang H.‐W. Li X.‐D. Niu J. Li 《Clinical and experimental dermatology》2015,40(3):293-297
Porocarcinoma is an unusual, locally aggressive and potentially fatal neoplasm. Several cutaneous malignancies have been described in association with porocarcinoma, including squamous cell carcinoma, basal cell carcinoma and tricholemmal carcinoma. Previous reports have indicated that the occurrence of malignant tumours in combination with porocarcinoma is extremely rare, in particular with regard to Bowen disease (BD). We report an uncommon case of porocarcinoma occurring synchronously in a single BD lesion in a 63‐year‐old woman with multiple BD lesions. The clinical and histological findings confirmed this diagnosis. 相似文献
74.
Yulong Lian Jing Xiao Chen Zhang Suzhen Guan Fuye Li Hua Ge 《Archives of environmental & occupational health》2016,71(2):74-84
The present study compared the level of occupational strain and work ability among Han, Hui, Uygur, Hui, and Kazakh teachers, and explored ethnic differences based on the associations of psychosocial factors at work, occupational strain, and work ability. A cross-sectional survey was conducted among 2,941 teachers in primary and secondary schools in Xinjiang Province, China. Psychosocial factors, occupational strain, and work ability were measured using the Occupation Stress Inventory—Revised Edition (OSI-R) and Work Ability Index. Han and Hui teachers experienced reduced work ability compared with Uygur and Kazakh teachers, and this finding was caused, in part, by exposure to psychosocial factors at work. The vocational and psychological strains caused by these factors play an important role in reduced work ability among all ethnic teacher groups. The findings indicate the importance of taking action to reduce occupational strain for promoting teachers' work ability in multiethnic workplaces. 相似文献
75.
76.
77.
78.
Edward J. Holland Walter O. Whitley Kenneth Sall Stephen S. Lane Aparna Raychaudhuri Steven Y. Zhang 《Current medical research and opinion》2016,32(10):1759-1765
Objective: Report efficacy findings from three clinical trials (one phase 2 and two phase 3 [OPUS-1, OPUS-2]) of lifitegrast ophthalmic solution 5.0% for treatment of dry eye disease (DED).Research design and methods: Three 84-day, randomized, double-masked, placebo-controlled trials. Adults (≥18 years) with DED were randomized (1:1) to lifitegrast 5.0% or matching placebo. Changes from baseline to day 84 in signs and symptoms of DED were analyzed.Main outcome measures: Phase 2, pre-specified endpoint: inferior corneal staining score (ICSS; 0–4); OPUS-1, coprimary endpoints: ICSS and visual-related function subscale (0–4 scale); OPUS-2, coprimary endpoints: ICSS and eye dryness score (EDS, VAS; 0–100).Results: Fifty-eight participants were randomized to lifitegrast 5.0% and 58 to placebo in the phase 2 trial; 293 to lifitegrast and 295 to placebo in OPUS-1; 358 to lifitegrast and 360 to placebo in OPUS-2. In participants with mild-to-moderate baseline DED symptomatology, lifitegrast improved ICSS versus placebo in the phase 2 study (treatment effect, 0.35; 95% CI, 0.05–0.65; p?=?0.0209) and OPUS-1 (effect, 0.24; 95% CI, 0.10–0.38; p?=?0.0007). Among more symptomatic participants (baseline EDS ≥40, recent artificial tear use), lifitegrast improved EDS versus placebo in a post hoc analysis of OPUS-1 (effect, 13.34; 95% CI, 2.35–24.33; nominal p?=?0.0178) and in OPUS-2 (effect, 12.61; 95% CI, 8.51–16.70; p?<?0.0001).Limitations: Trials were conducted over 12 weeks; efficacy beyond this period was not assessed.Conclusions: Across three trials, lifitegrast improved ICSS in participants with mild-to-moderate baseline symptomatology in two studies, and EDS in participants with moderate-to-severe baseline symptomatology in two studies. Based on the overall findings from these trials, lifitegrast shows promise as a new treatment option for signs and symptoms of DED. 相似文献
79.
Iva Justini Ana Kati Deni Uri
i Boena urko‐Cofek Branka Blagovi Gordana anadi Jurei 《Environmental toxicology》2020,35(3):346-358
The yeast Saccharomyces cerevisiae is a useful model for studying the influence of different stress factors on eukaryotic cells. In this work we used the pesticide imidacloprid, in the Confidor formulation, as the stress factor and analyzed its influence on the metabolic activity, proteome and lipid content and composition of Saccharomyces cerevisiae yeast. During the cultivation of yeast, the lowest recommended application dose of Confidor (0.025%, v/v) was added to the growth media and its influence on the mitochondria, cytosol with microsomes, and the whole yeast cells was monitored. The results show that under the stress provoked by the toxic effects of Confidor, yeast cells density significantly decreased and the percentage of metabolically disturbed cells significantly increased comparing with untreated control. Also, there was a downregulation of majority of glycolytic, gluconeogenesis, and TCA cycle enzymes (Fba1, Adh1, Hxk2, Tal1, Tdh1,Tdh3, Eno1) thus providing enough acetyl‐CoA for the lipid restructuring and accumulation mechanism since we have found the changes in the cell and mitochondrial lipid content and FA composition. This data suggest that lipids could be the molecules that orchestrate the answer of the cells in the stress response to the Confidor treatment. 相似文献