收费全文 | 5829篇 |
免费 | 361篇 |
国内免费 | 5篇 |
耳鼻咽喉 | 72篇 |
儿科学 | 296篇 |
妇产科学 | 129篇 |
基础医学 | 916篇 |
口腔科学 | 74篇 |
临床医学 | 443篇 |
内科学 | 1035篇 |
皮肤病学 | 96篇 |
神经病学 | 481篇 |
特种医学 | 189篇 |
外科学 | 636篇 |
综合类 | 18篇 |
现状与发展 | 1篇 |
一般理论 | 6篇 |
预防医学 | 680篇 |
眼科学 | 62篇 |
药学 | 487篇 |
中国医学 | 1篇 |
肿瘤学 | 573篇 |
2023年 | 36篇 |
2022年 | 44篇 |
2021年 | 81篇 |
2020年 | 72篇 |
2019年 | 72篇 |
2018年 | 130篇 |
2017年 | 100篇 |
2016年 | 113篇 |
2015年 | 128篇 |
2014年 | 175篇 |
2013年 | 209篇 |
2012年 | 370篇 |
2011年 | 347篇 |
2010年 | 190篇 |
2009年 | 195篇 |
2008年 | 302篇 |
2007年 | 331篇 |
2006年 | 306篇 |
2005年 | 265篇 |
2004年 | 220篇 |
2003年 | 200篇 |
2002年 | 197篇 |
2001年 | 181篇 |
2000年 | 175篇 |
1999年 | 185篇 |
1998年 | 51篇 |
1997年 | 71篇 |
1996年 | 60篇 |
1995年 | 50篇 |
1994年 | 58篇 |
1993年 | 60篇 |
1992年 | 109篇 |
1991年 | 108篇 |
1990年 | 98篇 |
1989年 | 112篇 |
1988年 | 103篇 |
1987年 | 89篇 |
1986年 | 80篇 |
1985年 | 81篇 |
1984年 | 60篇 |
1983年 | 44篇 |
1982年 | 21篇 |
1981年 | 25篇 |
1979年 | 27篇 |
1978年 | 25篇 |
1974年 | 33篇 |
1973年 | 27篇 |
1972年 | 16篇 |
1971年 | 23篇 |
1966年 | 15篇 |
Essentials
- Why venous thrombosis is more prevalent in chronic kidney disease is unclear.
- We investigated whether renal and vascular function are associated with hypercoagulability.
- Coagulation factors showed a procoagulant shift with impaired renal and vascular function.
- This suggests that renal and vascular function play a role in the etiology of thrombosis.
Summary
Background
Impaired renal and vascular function have been associated with venous thrombosis, but the mechanism is unclear.Objectives
We investigated whether estimated glomerular filtration rate (eGFR), urinary albumin‐creatinine ratio (UACR), and pulse wave velocity (PWV) are associated with a procoagulant state.Methods
In this cross‐sectional analysis of the NEO Study, eGFR, UACR, fibrinogen, and coagulation factors (F)VIII, FIX and FXI were determined in all participants (n = 6536), and PWV was assessed in a random subset (n = 2433). eGFR, UACR and PWV were analyzed continuously and per percentile: per six categories for eGFR (> 50th [reference] to < 1st) and UACR (< 50th [reference] to > 99th), and per four categories (< 50th [reference] to > 95th percentile) for PWV. Linear regression was used and adjusted for age, sex, total body fat, smoking, education, ethnicity, total cholesterol, C‐reactive protein (CRP) and vitamin K antagonists use (FIX).Results
Mean age was 55.6 years, mean eGFR 86.0 (12SD) mL 1.73 m?² and median UACR 0.4 mg mmol?1 (25th, 75th percentile; 0.3, 0.7). All coagulation factors showed a procoagulant shift with lower renal function and albuminuria. For example, FVIII was 22 IU dL?1 (95% CI, 13–32) higher in the eGFR < 1st percentile compared with the > 50th percentile, and FVIII was 12 IU dL?1 (95% CI, 3–22) higher in the UACR > 99th percentile compared with the < 50th percentile. PWV was positively associated with coagulation factors FIX and FXI in continuous analysis; per m/s difference in PWV, FIX was 2.0 IU dL?1 (95% CI, 0.70–3.2) higher.Conclusions
Impaired renal and vascular function was associated with higher levels of coagulation factors, underlining the role of renal function and vascular function in the development of venous thrombosis.Harmonised mixture information requirements: Detailed and consistent information on the composition of the hazardous product will become available to EU Poisons Centres (PC). The information will be submitted by companies to PCs (or equivalent “appointed bodies”) using a web-based software application or in-house software. Two new important features are introduced. Firstly, to be able to rapidly identify the product formula, a Unique Formula Identifier (UFI) on the product label links to the submitted information. Secondly, for better comparability of reports on poisonings between EU member states, a harmonised Product Categorisation System will specify the intended use of a product. Rapid product identification and availability of detailed composition information will lead to timely and adequate medical intervention. This may lead to considerable reduction in healthcare costs.
Additionally, for companies trading across the EU, costs of submission of this information will be reduced significantly.
Next steps: From 2017, an implementation period has started, consisting of a three-year period for stakeholders to implement the new requirements, followed by a gradual applicability for consumer products (2020), professional products (2021) and industrial use-only products (2024). Technical tools to generate the electronic format and the UFI together with guidance documents are expected to be made available by the end of 2017 by the European Chemicals Agency (ECHA). Guidance on interpretation of legal text and ECHA helpdesk support are planned to be ready at the end of 2018. 相似文献