全文获取类型
收费全文 | 24435篇 |
免费 | 1068篇 |
国内免费 | 90篇 |
专业分类
耳鼻咽喉 | 423篇 |
儿科学 | 652篇 |
妇产科学 | 651篇 |
基础医学 | 4518篇 |
口腔科学 | 565篇 |
临床医学 | 1559篇 |
内科学 | 3583篇 |
皮肤病学 | 728篇 |
神经病学 | 2054篇 |
特种医学 | 2071篇 |
外科学 | 3328篇 |
综合类 | 196篇 |
一般理论 | 2篇 |
预防医学 | 1786篇 |
眼科学 | 365篇 |
药学 | 2176篇 |
中国医学 | 142篇 |
肿瘤学 | 794篇 |
出版年
2023年 | 138篇 |
2022年 | 251篇 |
2021年 | 470篇 |
2020年 | 283篇 |
2019年 | 388篇 |
2018年 | 641篇 |
2017年 | 481篇 |
2016年 | 588篇 |
2015年 | 626篇 |
2014年 | 788篇 |
2013年 | 1265篇 |
2012年 | 1742篇 |
2011年 | 2016篇 |
2010年 | 1125篇 |
2009年 | 632篇 |
2008年 | 1240篇 |
2007年 | 1446篇 |
2006年 | 1421篇 |
2005年 | 1181篇 |
2004年 | 1103篇 |
2003年 | 1081篇 |
2002年 | 881篇 |
2001年 | 657篇 |
2000年 | 833篇 |
1999年 | 567篇 |
1998年 | 221篇 |
1997年 | 185篇 |
1996年 | 142篇 |
1995年 | 148篇 |
1994年 | 115篇 |
1993年 | 84篇 |
1992年 | 123篇 |
1991年 | 123篇 |
1990年 | 138篇 |
1989年 | 126篇 |
1988年 | 117篇 |
1987年 | 102篇 |
1986年 | 96篇 |
1985年 | 132篇 |
1984年 | 106篇 |
1983年 | 123篇 |
1982年 | 102篇 |
1981年 | 97篇 |
1980年 | 79篇 |
1979年 | 100篇 |
1978年 | 98篇 |
1977年 | 81篇 |
1976年 | 83篇 |
1975年 | 87篇 |
1973年 | 70篇 |
排序方式: 共有10000条查询结果,搜索用时 234 毫秒
71.
AIM--To identify rapidly and accurately coryneform bacteria, using a commercial strip system. METHODS--Ninety eight strains of Corynebacterium species and 62 additional strains belonging to genera Erysipelothrix, Oerskovia, Rhodococcus, Actinomyces, Archanobacterium, Gardnerella and Listeria were studied. Bacteria were identified using conventional biochemical tests and a commercial system (API-Coryne, BioMèrieux, France). Fresh rabbit serum was added to fermentation tubes for Gardnerella vaginalis isolates. RESULTS--One hundred and five out of the 160 (65.7%) organisms studied were correctly and completely identified by the API Coryne system. Thirty five (21.8%) more were correctly identified with additional tests. Seventeen (10.6%) organisms were not identified by the system and three (1.9%) were misidentified. CONCLUSIONS--The system was a good alternative for identification of coryneform organisms. When occasionally performed with some additional tests, this method permits reliable and rapid identification of coryneform organisms compared with conventional methods. 相似文献
72.
73.
74.
Tomáš Šimůnek Martin Štěrba Olga Popelová Michaela Adamcová Radomír Hrdina Vladimír Geršl 《Pharmacological reports : PR》2009,61(1):154-171
The risk of cardiotoxicity is the most serious drawback to the clinical usefulness of anthracycline antineoplastic antibiotics, which include doxorubicin (adriamycin), daunorubicin or epirubicin. Nevertheless, these compounds remain among the most widely used anticancer drugs. The molecular pathogenesis of anthracycline cardiotoxicity remains highly controversial, although the oxidative stress-based hypothesis involving intramyocardial production of reactive oxygen species (ROS) has gained the widest acceptance. Anthracyclines may promote the formation of ROS through redox cycling of their aglycones as well as their anthracycline-iron complexes. This proposed mechanism has become particularly popular in light of the high cardioprotective efficacy of dexrazoxane (ICRF-187). The mechanism of action of this drug has been attributed to its hydrolytic transformation into the iron-chelating metabolite ADR-925, which may act by displacing iron from anthracycline-iron complexes or by chelating free or loosely bound cellular iron, thus preventing site-specific iron-catalyzed ROS damage. However, during the last decade, calls for the critical reassessment of this “ROS and iron” hypothesis have emerged. Numerous antioxidants, although efficient in cellular or acute animal experiments, have failed to alleviate anthracycline cardiotoxicity in clinically relevant chronic animal models or clinical trials. In addition, studies with chelators that are stronger and more selective for iron than ADR-925 have also yielded negative or, at best, mixed outcomes. Hence, several lines of evidence suggest that mechanisms other than the traditionally emphasized “ROS and iron” hypothesis are involved in anthracycline-induced cardiotoxicity and that these alternative mechanisms may be better bases for designing approaches to achieve efficient and safe cardioprotection. 相似文献
75.
76.
V. Prát M. Horčičková K. Matoušovic M. Hatala 《International urology and nephrology》1990,22(3):201-207
Fifty-four patients with complicated UTI were administered ciprofloxacin in doses of 500 mg (30 subjects) and 250 mg (24 subjects)
at 12-hour intervals. While a positive effect was noted in 96–100% upon termination of therapy, the effect was still present
3 weeks later in 90% of the high-dose, but only in 71% of the low-dose group. In 23 patients with uncomplicated UTI, a positive
effect of the three-day therapy with 100 mg of ciprofloxacin at 12-hour intervals was observed in 91% of subjects.
Intolerance to the agent was found in one case only. Development of resistance to ciprofloxacin was not observed. 相似文献
77.
78.
A rapidly growing, malignant schwannoma occurred in a 46-year-old woman with neurofibromatosis. Computed tomography, isotope bone scan, chest roentgenogram, and angiogram are helpful in determining the local extent and distant spread of such musculoskeletal tumors and are useful in planning appropriate surgical management. A well-planned biopsy, however, is essential to accurately determine the histologic diagnosis of the tumor. Clinical and roentgenographic presentation of some benign lesions may mimic malignant tumors. To confirm the diagnosis of a malignant or benign tumor, it is advisable to examine the musculoskeletal tumor histologically before proceeding with the definitive treatment, even if the clinical presentation strongly suggests malignancy. 相似文献
79.
A. Dmoszyńska-Giannopoulou L. Janicka B. Sokołowska A. Ksi⇂żek G. Orłowska K. Janicki 《International urology and nephrology》1990,22(6):561-566
In 30 patients on chronic haemodialysis treatment the platelet activity and function were studied before and during antiplatelet
therapy with alpha-tocopherol and sulphinpyrazone. In both kinds of treatment a significant decrease of ADP-induced and spontaneous
aggregation was observed. Sulphinpyrazone exerts an inhibitory effect not only on platelet aggregation but also on platelet
factor 3 and provokes a significant prolongation of the bleeding time. 相似文献
80.