Non-Hodgkin's lymphoma of prostate: a rare site of primary extranodal presentation (a report of two cases)

We report two cases of primary extranodal lymphoma of the prostate, an unusual site for extranodal presentation. The clinical presentation and treatment is discussed.     

对氧磷酯酶基因多态性与糖尿病肾病的关系

目的探讨对氧磷酯酶2(PON2)基因A148G多态性与糖尿病肾病的关系.方法(1)用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析法探查PON2基因A148G多态性在正常对照组、单纯2型糖尿病组、糖尿病肾病组中的基因频率分布;(2)放射免疫法检测血清免疫反应性胰岛素(IRI)、C肽(C-P)水平.结果(1)糖尿病肾病组GG基因型和G等位基因频率明显高于单纯2型糖尿病组(X2=4.26 P＜0.05,X2=4.89P＜0.05)和正常对照组(X2=4.79 P＜0.05,X2=5.49P＜0.01);(2)基因型为GG的糖尿病患者空腹血糖浓度高于基因型为GA和AA的糖尿病患者的空腹血糖浓度(F=3.90 P＜0.05,F=4.23 P＜0.05);(3)Logistic回归分析表明GG基因型是糖尿病肾病的独立变异危险因素(P＜0.05).结论PON2基因多态性与糖尿病肾病的发生有关.     

Testicular dysfunction after cyclophosphamide-vincristine-procarbazine-prednisolone chemotherapy for advanced Hodgkin's disease. A long-term follow-up study

Gonadal functions were evaluated in 92 male patients after treatment for advanced Hodgkin's disease. The patients received six to ten cycles of cyclophosphamide, vincristine, procarbazine, and prednisolone (COPP) chemotherapy. All patients were in remission and were followed for 1 to 17 years (median, 6). Testicular atrophy was noticed in 89 (96.7%) patients. All patients remained azoospermic during the period of follow-up. The testosterone levels did not differ before and after treatment. The follicle stimulating hormone levels rose from pretreatment values (mean +/- standard deviation) of 179.27 +/- 21.99 ng/ml to 578.79 +/- 102.36 ng/ml after the treatment; the rise was significant (P less than 0.001). The luteinizing hormone levels rose from pretreatment values of 106.96 +/- 20.37 ng/ml to 127.37 +/- 32.19 ng/ml after treatment; the rise was significant (P less than 0.05). Testicular biopsy specimens in 19 patients showed germinal aplasia in all cases. It is concluded that six or more cycles of COPP chemotherapy for advanced Hodgkin's disease in men leads to permanent sterility.     

Primary pulmonary non-Hodgkin's lymphoma: a report of four cases

Four cases of primary non-Hodgkin's lymphoma of the lung are described. Two cases had low and two intermediate grade lymphoma at the time of diagnosis. The patient who had disease for long duration and received pulmonary radiotherapy developed intractable chest infection and died six months after diagnosis; the three patients having short history of disease and treated with surgery and/or chemotherapy have been doing well for 4 to 77 months after the diagnosis. It is concluded that diagnosis of primary pulmonary lymphoma should be suspected in patients with nodular or interstitial lung disease and bronchoalveolar lavage with aspiration cytology should be done to make an early diagnosis.     

螺旋CT增强扫描在胆囊癌诊断中的价值

目的探讨螺旋CT多期增强扫描在胆囊癌诊断中的作用。方法对23例经病理证实的胆囊癌患者的多期螺旋CT表现进行回顾性分析。结果胆囊癌主要CT表现为胆囊壁的不规则增厚和结节状突起以及胆囊内的肿块，增强扫描强化明显且持续时间长。结论螺旋CT多期增强扫描在胆囊癌的定性诊断及了解胆囊癌的侵犯范围上具有重要作用。     

Use of panel testing for detection of antinuclear antibody in a resource-limited setting: an appraisal

Objectives: Despite an increase in the incidence of systemic connective tissue diseases (CTD), panel testing for detection of antinuclear antibodies (ANA) is not a routine practice in many health centers of the Indian subcontinent. Consequently, the data on its significance is scanty.

Methods: To evaluate utility of panel testing, line immunoassay (LIA) and indirect immunofluorescence antinuclear antibody test (IIF-ANA) were performed in 321 cases of CTD.

Results: Out of 321 serum samples screened by the above tests, 227 were positive and 18 were negative by both LIA and IIF-ANA. Additional 11/321 (3.4%) cases were picked up by LIA. SSA was most common specificity in these cases followed by SSA/SSB, SSB, Ro-52, Jo-1, dsDNA and nRNP/Sm.

Conclusion: Use of LIA along with IF-ANA and ELISA improves sensitivity of CTD screening.     

胰腺类癌7例临床分析

目的 分析胰腺类癌的临床特点及诊断.方法 回顾性分析该院7例胰腺类癌的临床资料.结果 4例患者表现为上腹部不适、饱胀或疼痛,1例为腰背部疼痛伴消瘦、乏力,1例表现为类癌综合征,1例为检查时意外发现.出现肝转移者2例,淋巴结肿大者4例.免疫组化:NSE阳性者5例,Syn阳性者5例,CgA阳性者6例.能准确定位的影像学检查有CT(5/7)、超声内镜(3/4).结论 胰腺类癌临床以缺乏特征性的上腹不适为主,典型类癌综合征少见,确诊主要依据病理及免疫组化,超声内镜及CT在定位诊断上有重要意义.     

Titanium elastic nailing in femoral diaphyseal fractures of children in 6-16 years of age

Background:

Management of femoral diaphyseal fractures in the age group of 6-16 years is controversial. There has been a resurgence worldwide for operative fixation.

Materials and Methods:

Twenty-two children (18 boys, 4 girls) aged 6-16 years with recent (> 3 days) femoral diaphyseal fractures (20 closed, 2 open) were stabilized with Titanium Elastic Nail (TEN). These fractures were in proximal third (n=3), middle third (n=15) and in the distal third (n=4) 17 patients underwent surgery within seven days of their injury. The results were evaluated using Flynn''s scoring criteria. Statistical analysis was done using Fischer''s exact test.

Results:

All 22 patients were available for evaluation after a mean of 26 months (14-36 months) of followup. Radiological union in all cases were achieved in a mean time of 8.7 weeks. Full weight bearing was possible in a mean time of 8.8 weeks. Mean duration of hospital stay was 9.8 days. The results were excellent in 13 patients (59.0%), successful in six (27.2%) and poor in three patients (13.6%). All patients had early return to school.

Conclusion:

Intramedullary fixation titanium elastic nailing is an effective treatment of diaphyseal fractures of the femur in properly selected patients of the 6-16 years age group.