A collaborative care approach to complex diabetic foot ulceration

This article highlights the complex issues that surround the management of diabetic foot ulceration. It describes how the disciplines of podiatry and tissue viability came together to care for a patient who required complex wound management. The importance of collaborative working is highlighted, which has been shown to reduce amputation rates by 50% (Edmonds, 2002). Through exploration of a case study, certain issues emerged--wound infection, wound management, psychosocial factors and teamworking--and these are discussed. The link between diabetic foot ulceration and amputation is explored and the argument put forward that amputation should have been the first choice for this patient bearing in mind that 30% of amputees lose their second leg within 5 years (Geary, 2002).     

Achieving compliance with the European Working Time Directive in a large teaching hospital: a strategic approach

This paper describes the strategy which achieved European Working Time Directive (EWTD) compliance at the Royal Free Hampstead NHS Trust in medicine and surgery. Compliance with EWTD regulations was assessed by diary card exercise, clinical care assessed through critical incident reports, electronic handover documents and nursing reports, training opportunities assessed by unit training directors, cost controls assessed by finance department analysis, and workload assessed by staff attendance on wards, in casualty and in theatres. There was a change in focus of care to a consultant-led, specialist registrar- (SpR-)driven service extending into evenings and on weekends, coupled with a move to a multi-skilled team for night cover, and to a move from traditional on-call shifts to a full shift system across both medicine and surgery. Compliance with the EWTD was achieved whilst maintaining good standards of clinical care, ensuring training opportunities for doctors in training, controlling payroll costs, removing the need for locums, and reducing workload for both junior doctors and consultants.     

Optimization of technetium-99m Sestamibi single-photon emission tomography to define multidrug resistance with confidence

BACKGROUND: The efflux rate of technetium-99m Sestamibi (99mTc-Sestamibi) is a kinetic phenomenon related to the response of cancer cells to chemotherapy, and may be used to determine drug resistance. Measurement of the efflux rate requires accurate quantitative single-photon emission tomography (SPET) imaging within the time constraints imposed by the kinetics of the process. METHODS: A phantom study, at activity concentrations typically found with 99mTc-Sestamibi in vivo, was undertaken to optimize the SPET parameters and, in particular, to determine whether 180 degrees acquisition arcs with heads in 'L' configuration could be used for accurate quantification. Following the development of the most appropriate SPET protocol, a small patient pilot study was undertaken. RESULTS: Studies designed to evaluate statistical uncertainty (noise), contrast restitution and spatial resolution of the data sets, using different acquisition and reconstruction parameters, showed that 180 degrees SPET using a 64 x 64 matrix, 6 degrees angular sampling and iterative reconstruction was optimal. Finer linear and/or angular sampling afforded negligible improvement in resolution, but markedly increased the statistical uncertainty. Comparison of 360 degrees and 180 degrees acquisitions, utilizing conventional filtered backprojection and iterative reconstruction algorithms, demonstrated that the statistical uncertainty was reduced to a greater extent for 180 degrees data collection. For 360 degrees (64 x 64) data acquisition, statistical uncertainty decreased from 15% to 11% using the iterative algorithm, whilst the 180 degrees (64 x 64) data showed a reduction from 20% to 7%, and approached values obtained by planar imaging. The efflux measurements obtained in the patient pilot study were consistent with the observed chemotherapy response. CONCLUSION: Our study shows that 180 degrees acquisition arcs are a practical option for accurate quantitative SPET kinetic imaging for potential studies of chemotherapy response in patients with lung cancer.     

Laparoscopic surgery for pancreatic tumors, an uptake

Laparoscopy is not universally accepted as the best approach for pancreatic tumor disease. It is considered an élite surgical approach especially because of the technical difficulties involved; and the highly trained surgeons that are required to perform these operations. In addition, long operation times and lack of reduction in length of hospital stay press for the use of the laparotomic approach instead of a laparoscopic one. Four major areas of interest have been focused on: pancreaticoduodenectomy, pancreas resection and enucleation, the increasingly important areas of diagnostic laparoscopy for staging of pancreatic cancer and laparoscopic palliation of unresectable pancreatic cancer. A review of the literature about laparoscopic management of pancreatic tumors disease has been examined: 14 laparoscopic pancreaticoduodenectomies, 93 pancreatic resections, 41 enucleations, 4 left pancreatectomies and 2 hand assisted enucleations have been described since 1994. The laparoscopic distal pancreas resection and enucleation appear to be the best treatment option for lesions located in the body and tail of the gland; conversely laparoscopy may not be indicated for lesions located in the head of the gland. The laparoscopic approach today, does not present advantages in terms of post-operative outcome and operation times than the laparotomic approach. The hand assisted approach may be helpful in difficult cases to facilitate the operation; it permits an easier and safer dissection still conserving a minimally invasive approach. Moreover, laparoscopy is also becoming the best approach for tumor staging and palliation, and many surgeons use the laparoscopy to obtain the most information with the minimal damage in a situation already compromised by a weakening disease.     

The relation between trauma center outcome and volume in the National Trauma Databank

BACKGROUND: Regionalization of trauma care services aims to improve outcomes by limiting trauma care delivery to a select group of dedicated trauma centers. However, the evidence linking trauma center volume and outcome is not conclusive. The objective of this study was to examine the volume-mortality relation for patients with severe trauma in the National Trauma Databank. METHODS: This study was based on data for adult patients 18 years of age or older in the National Trauma Databank with an Injury Severity Score (ISS) of 15 or more who sustained either blunt or penetrating trauma. The main outcome measure was in-hospital survival as a function of trauma center volume. Logistic regression modeling was used to analyze the relation between survival and hospital volume for patients sustaining either severe blunt or severe penetrating trauma. RESULTS: For the blunt trauma cohort, model diagnostics showed that the single highest-volume center was an outlier. After exclusion of the patients from this center, no association could be demonstrated between trauma volume and outcome (p = 0.465) for blunt trauma. A separate multivariate analysis of patients with penetrating trauma also could not demonstrate a significant volume-mortality association (p = 0.919). Both regression models exhibited excellent discrimination and acceptable calibration. CONCLUSION: The findings of this study do not support the position that higher trauma center volumes are associated with improved survival. The implication of this study is that the hospital volume criteria established by the American College of Surgeons may need to be reexamined.     

An evaluation of continuous positive airway pressure (CPAP) therapy in the treatment of hypernasality following traumatic brain injury: a report of 3 cases

OBJECTIVE: To evaluate the effectiveness of continuous positive airway pressure (CPAP) therapy in the treatment of hypernasality following traumatic brain injury (TBI). DESIGN: An A-B-A experimental research design. Assessments were conducted prior to commencement of the program, midway, immediately posttreatment, and 1 month after completion of the CPAP therapy program. PARTICIPANTS: Three adults with dysarthria and moderate to severe hypernasality subsequent to TBI. OUTCOME MEASURES: Perceptual evaluation using the Frenchay Dysarthria Assessment, the Assessment of Intelligibility of Dysarthric Speech, and a speech sample analysis, and instrumental evaluation using the Nasometer. RESULTS: Between assessment periods, varying degrees of improvement in hypernasality and sentence intelligibility were noted. At the 1-month post-CPAP assessment, all 3 participants demonstrated reduced nasalance values, and 2 exhibited increased sentence intelligibility. CONCLUSIONS: CPAP may be a valuable treatment of impaired velopharyngeal function in the TBI population.