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151.
152.
Yoichi Toma Yasuo Matsuda Kohshiro Moritani Tsutomu Ryoke Kazuhiro Katayama Toshiro Miura Hiroshi Ogawa Masako Matsuda Masunori Matsuzaki Reizo Kusukawa 《Catheterization and cardiovascular interventions》1989,18(2):85-89
This study observed the left atrial function in determining filling dynamics of the left ventricle in patients with myocardial infarction. The study consisted of eight control subjects and ten patients with myocardial infarction. The left ventricular filling volume is considered to be composed of the left atrial passive emptying, active emptying, and conduit volumes. The change of left ventricular filling volume was correlated with that of conduit volume (r = .87, P < .01). However, the change of left ventricular filling volume did not have any correlation to those of left atrial passive emptying and active emptying volumes. These results suggested that the left atrial conduit function was important in determining filling dynamics of the left ventricle. 相似文献
153.
154.
Treatment of rheumatoid arthritis with humanized anti-interleukin-6 receptor antibody: a multicenter, double-blind, placebo-controlled trial 总被引:25,自引:0,他引:25
Nishimoto N Yoshizaki K Miyasaka N Yamamoto K Kawai S Takeuchi T Hashimoto J Azuma J Kishimoto T 《Arthritis and rheumatism》2004,50(6):1761-1769
OBJECTIVE: Interleukin-6 (IL-6) is a pleiotropic cytokine that regulates the immune response, inflammation, and hematopoiesis. Overproduction of IL-6 plays pathologic roles in rheumatoid arthritis (RA), and the blockade of IL-6 may be therapeutically effective for the disease. This study was undertaken to evaluate the safety and efficacy of a humanized anti-IL-6 receptor antibody, MRA, in patients with RA. METHODS: In a multicenter, double-blind, placebo-controlled trial, 164 patients with refractory RA were randomized to receive either MRA (4 mg/kg body weight or 8 mg/kg body weight) or placebo. MRA was administered intravenously every 4 weeks for a total of 3 months. The clinical responses were measured using the American College of Rheumatology (ACR) criteria. RESULTS: Treatment with MRA reduced disease activity in a dose-dependent manner. At 3 months, 78% of patients in the 8-mg group, 57% in the 4-mg group, and 11% in the placebo group achieved at least a 20% improvement in disease activity according to the ACR criteria (an ACR20 response) (P < 0.001 for 8-mg group versus placebo). Forty percent of patients in the 8-mg group and 1.9% in the placebo group achieved an ACR50 response (P < 0.001). The overall incidences of adverse events were 56%, 59%, and 51% in the placebo, 4-mg, and 8-mg groups, respectively, and the adverse events were not dose dependent. A blood cholesterol increase was observed in 44.0% of the patients. Liver function disorders and decreases in white blood cell counts were also observed, but these were mild and transient. There was no increase in antinuclear antibodies or anti-DNA antibodies. Anti-MRA antibodies were detected in 2 patients. CONCLUSION: Treatment with MRA was generally well tolerated and significantly reduced the disease activity of RA. 相似文献
155.
A lipoprotein lipase activator,NO-1886 prevents impaired endothelium-dependent relaxation of aorta caused by exercise in aged rats 总被引:2,自引:0,他引:2
Kusunoki M Tsutsumi K Hara T Ogawa H Nakamura T Miyata T Sakakibara F Fukuzawa Y Suga T Kakumu S Nakaya Y 《Experimental gerontology》2002,37(7):891-896
Exercise decreases plasma total cholesterol and triglycerides, and simultaneously, increases high density lipoprotein (HDL) cholesterol. As a result, exercise is believed to aid in preventing atherosclerosis. However, we do not know whether exercise protects against the development of atherosclerosis in the elderly. The aim of this study was to ascertain whether the lipoprotein lipase activator NO-1886 had an effect on the prevention of atherosclerosis in aged rats which undergo exercise. Exercise for 3 months did not affect plasma lipids but decreased the accumulation of visceral fat in 2-year-old rats (aged rat). Exercise also resulted in an elevation of plasma lipid peroxide (LPO) levels and impaired the endothelium-dependent relaxation of the thoracic aorta caused by acetylcholine in aged rats. On the other hand, NO-1886 decreased plasma triglycerides and increased HDL cholesterol and suppressed the elevation of plasma LPO levels caused by exercise. Furthermore, NO-1886 prevented impaired endothelium-dependent relaxation caused by exercise. In summary, the results of our study indicate that exercise may cause impaired endothelium-dependent relaxation by elevation of LPO in aged rats, and that NO-1886 prevents this impaired endothelium-dependent relaxation of aorta by reducing plasma triglycerides, elevating HDL cholesterol, and suppressing the elevation of plasma LPO caused by exercise. 相似文献
156.
Kosuke Okuwaki Hironori Masutani Hiroshi Imaizumi Tsutomu Yoshida Mitsuhiro Kida Tomohisa Iwai Hiroshi Yamauchi Masayoshi Tadehara Kai Adachi Masafumi Watanabe Takahiro Kurosu Wasaburo Koizumi 《Pancreatology》2019,19(3):419-423
Background/Objectives
A breakthrough in chemotherapy for pancreatic ductal adenocarcinoma (PDAC) may be achieved using precision medicine, which involves identifying cases that are highly likely to respond to a certain treatment and then performing that treatment. BRCAness has been receiving attention as a novel predictor of anticancer drug sensitivity in PDAC, making the screening of BRCAness paramount.Methods
We conducted the first-ever examination of the feasibility of analyzing BRCAness using multiplex ligation-dependent probe amplification (MLPA). Formalin-fixed paraffin-embedded (FFPE) tissue samples obtained via endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) from 20 patients with the highest pancreatic carcinoma cell counts in tissue samples out of 40 consecutive PDAC patients who underwent EUS-FNAB at our hospital were analyzed by MLPA for BRCAness.Results
We were able to accurately analyze BRCAness in 75% of the 20 cases of PDAC using FFPE tissue obtained by EUS-FNAB. BRCAness was observed in one of the 20 cases.Conclusions
In PDAC, analyzing BRCAness by MLPA using FFPE tissue obtained by EUS-FNAB offers the remarkable benefit of yielding results in a short period of time and at a low cost. In addition, this method of BRCAness analysis may prove to be a feasible and effective approach for performing precision medicine. 相似文献157.
Tomoko Ohura Tsutomu Tsuyama Takeo Nakayama 《Journal of Physical Therapy Science》2015,27(12):3837-3841
[Purpose] This study aimed to clarify differences in understanding and subjective effects
of home-visit rehabilitation between user families and rehabilitation providers.
[Subjects] The subjects were home-visit rehabilitation providers and user families.
[Methods] Home-visit rehabilitation providers and user families completed a
self-administered questionnaire regarding the content and subjective effects of home-visit
rehabilitation. For statistical analysis, the McNemar’s test was used. [Results] Fifty
pairs of responses met the inclusion criteria. The mean age of user families was 65.0 ±
11.2 years, and 58.0% (29/50) were spouses of users (user mean age, 77.7 ± 10.2 years;
48.0% (24/50) female). With regard to home-visit rehabilitation content, user families
thought that paralysis improvement exercise, massage, and self-care activities were
implemented to a greater degree than did rehabilitation providers. With regard to the
subjective effects of home-visit rehabilitation, a higher proportion of user families
noticed “maintenance/improvement” effects on symptoms and sequelae, as well as pain and
suffering, compared with providers. [Conclusion] User families believed that
rehabilitation would also improve users’ symptoms and pain. Care providers should explain
the aims of home-visit rehabilitation to users and their families, both of which require a
strong understanding of home-visit rehabilitation in order to achieve rehabilitation
goals.Key words: Home-visit rehabilitation, Family’s subjective effects, Rehabilitation program 相似文献
158.
Keiichi Tsuji Hiroyasu Ishida Kaori Oba Tsutomu Ueki Yuichiro Fujihashi 《Journal of Physical Therapy Science》2015,27(2):353-356
[Purpose] The present study aimed to determine changes in muscle activity while moving on
a treadmill at various speeds. [Subjects] The activities of the left vastus lateralis,
vastus medialis, hip adductors, lateral head of gastrocnemius, medial head gastrocnemius,
soleus, and tibialis anterior of 10 healthy male university students were analyzed.
[Methods] University students walked, jogged, and ran for 10 minutes each in random order,
and then myogenic potentials were measured 10 minutes later for 30 seconds. The flexion
angle of the lower limb upon initial contact, mid stance, and toe off were measured.
[Results] The average walking, jogging, and running speeds were 3.6 ± 0.4, 6.7 ± 0.6, and
10.4 ± 1.3 km/h, respectively. The average electromyographic activities of the vastus
medial, tibialis anterior, medial head of gastrocnemius, and lateral head of gastrocnemius
significantly differed. All muscles were more active during jogging and running than
walking. Only the soleus was more active during running than walking, and the activities
of the hip adductors and vastus lateralis did not significantly differ. [Conclusion]
Velocity is faster and the angles of the lower limbs and ground reaction force (GRF) are
larger during running than walking. The vastus medialis and soleus worked more easily
according to the angle of the knee joint, whereas the tibialis anterior worked more easily
at faster velocities and the medial and lateral heads of the gastrocnemius worked more
easily with an increased GRF.Key words: Walking, Running, Skeletal muscle 相似文献
159.
Glutathione-S-transferase P1-1 protects aberrant crypt foci from apoptosis induced by deoxycholic acid 总被引:4,自引:0,他引:4
Nobuoka A Takayama T Miyanishi K Sato T Takanashi K Hayashi T Kukitsu T Sato Y Takahashi M Okamoto T Matsunaga T Kato J Oda M Azuma T Niitsu Y 《Gastroenterology》2004,127(2):428-443
BACKGROUND & AIMS: Aberrant crypt foci, precursors of colonic adenoma, are frequently positive for glutathione-S-transferase P1-1. Because deoxycholic acid is an apoptosis-inducing xenobiotic in the colon, we examined the possibility that aberrant crypt foci, through the cytoprotecting function of glutathione-S-transferase P1-1, resist deoxycholic acid-induced apoptosis, thereby surviving to become adenomas and subsequently cancer. METHODS: Glutathione-S-transferase P1-1 or cyclooxygenase-2 expression and the percentage of apoptotic cells in aberrant crypt foci were examined by immunohistochemistry and by terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling, respectively. Glutathione-S-transferase P1-1 was transfected into colon cancer cells (M7609) and human lung fibroblasts, and deoxycholic acid-induced apoptosis was evaluated by a dye-uptake assay and flow cytometry. Binding of deoxycholic acid to glutathione-S-transferase P1-1 was analyzed by circular dichroism and immunoprecipitation. Caspase activities were determined by colorimetric protease assay, and sulindac binding to glutathione-S-transferase P1-1 was determined by inhibition assay of glutathione-S-transferase P1-1 activity. RESULTS: Aberrant crypt foci showed positive immunostaining for glutathione-S-transferase P1-1 but negative staining for cyclooxygenase-2. The percentage of apoptotic cells in aberrant crypt foci was significantly lower than in healthy epithelium, and the difference became more apparent with deoxycholic acid treatment. The impaired sensitivity of aberrant crypt foci to deoxycholic acid was restored by the glutathione-S-transferase P1-1-specific inhibitor gamma-glutamyl-S-(benzyl)cysteinyl-R-phenylglycine diethylester. By transfection of glutathione-S-transferase P1-1, M7609 cells became more resistant to deoxycholic acid-induced apoptosis than mock transfectants. Direct binding of glutathione-S-transferase P1-1 to deoxycholic acid was proven by circular dichroism and by immunoprecipitation. The aberrant crypt foci in adenoma patients treated with sulindac, which was shown to bind to glutathione-S-transferase P1-1, underwent apoptosis in 4 days and mostly regressed in 2-3 months. CONCLUSIONS: Glutathione-S-transferase P1-1 protects aberrant crypt foci from deoxycholic acid-induced apoptosis and may play a pivotal role in early colon carcinogenesis. 相似文献
160.