全文获取类型
收费全文 | 367篇 |
免费 | 38篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 38篇 |
妇产科学 | 1篇 |
基础医学 | 41篇 |
口腔科学 | 12篇 |
临床医学 | 25篇 |
内科学 | 78篇 |
皮肤病学 | 8篇 |
神经病学 | 4篇 |
特种医学 | 52篇 |
外科学 | 24篇 |
综合类 | 8篇 |
预防医学 | 14篇 |
眼科学 | 57篇 |
药学 | 19篇 |
肿瘤学 | 25篇 |
出版年
2022年 | 1篇 |
2021年 | 2篇 |
2020年 | 2篇 |
2019年 | 3篇 |
2018年 | 8篇 |
2017年 | 7篇 |
2016年 | 6篇 |
2015年 | 13篇 |
2014年 | 20篇 |
2013年 | 13篇 |
2012年 | 9篇 |
2011年 | 6篇 |
2010年 | 9篇 |
2009年 | 22篇 |
2008年 | 11篇 |
2007年 | 5篇 |
2006年 | 11篇 |
2005年 | 8篇 |
2004年 | 7篇 |
2003年 | 10篇 |
2002年 | 9篇 |
2001年 | 17篇 |
2000年 | 3篇 |
1999年 | 6篇 |
1998年 | 20篇 |
1997年 | 28篇 |
1996年 | 27篇 |
1995年 | 17篇 |
1994年 | 25篇 |
1993年 | 14篇 |
1992年 | 7篇 |
1991年 | 8篇 |
1990年 | 4篇 |
1989年 | 9篇 |
1988年 | 6篇 |
1987年 | 3篇 |
1986年 | 3篇 |
1985年 | 5篇 |
1984年 | 2篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1981年 | 3篇 |
1980年 | 6篇 |
1976年 | 5篇 |
排序方式: 共有407条查询结果,搜索用时 0 毫秒
91.
Jay TR, Heald KA, Carless NJ, Topham DE, Downing R. The distribution of porcine pancreatic beta-cells at ages 5, 12 and 24 weeks. Xenotransplantation 1999; 6: 131-140. ©Munksgaard, Copenhagen Islet transplantation is a potential treatment for diabetes mellitus and porcine pancreata may provide a readily available source of islets. The size, number and distribution of islets within the pancreas may influence the choice of age of donor for xenotransplantation. Samples (n = 3 per age group) from the dorsal and ventral pancreas of 5-, 12- and 24-week-old hybrid pigs were fixed in formal saline, processed in paraffin wax and stained with an avidin/biotin immunohistochemical kit for insulin, glucagon, somatostatin and pancreatic polypeptide. The arrangement of endocrine cells within the pancreata were studied and mean diameter of β-cell groups were measured (from insulin stained sections) in 1 mm2 grid areas (n = 10 per section) and collated into groups according to size. Percentage volume density of β-cells in relation to the whole pancreas was calculated and also the distribution of β-cell groups, according to their size, within the total β-cell mass. There were differences in the frequency and arrangement of endocrine cells within islets at the different ages studied. β-Cell groups < 50 µm in diameter occupied 70 to 80% of the total β-cell mass at 5 weeks but, as the age of the pig increased, larger cell groups were more abundant. However, the percentage volume density of β-cells within the total pancreas did not change as the pancreas matured.This study shows that the endocrine porcine pancreas was maturing and its structure changed between the ages of 5 and 24 weeks. The relevance of these findings may have implications on the isolation and function of islets if young pigs are to be used as donors for transplantation as a treatment for diabetes mellitus. 相似文献
92.
93.
Peroneus longus and brevis tendon tears: MR imaging evaluation 总被引:4,自引:0,他引:4
94.
95.
Guido NJ Tytgat 《Journal of digestive diseases》2013,14(3):109-112
Improvement in digestive oncology will require the creation of multidisciplinary teams. Expert gastroenterologists who are super‐specializing in digestive oncology (onco‐gastroenterologists) should be in the center of such highly qualified teams. To fulfill this role the onco‐gastroenterologist will need adequate training in all aspects of diagnostic and therapeutic endoscopic activities related to digestive cancer. This article reflects the spectrum of expertise that will be necessary to guarantee optimal service. 相似文献
96.
BACKGROUND: Monoclonal antibody 148 is a murine monoclonal anti- glycophorin B that preferentially reacts with S+ human red cells. STUDY DESIGN AND METHODS: Serologic and immunochemical studies were performed using red cells with various phenotypes. RESULTS: These studies reveal that this monoclonal antibody is unusual in that it fails to agglutinate S+ TSEN+ red cells and agglutinates S- St(a+) and S- Dantu+ red cells. CONCLUSION: These results allow the prediction of the glycophorin composition of GP.Hop (Mi.IV) red cells. 相似文献
97.
Cerebral vasculitis--recognition, diagnosis and management 总被引:1,自引:0,他引:1
Scolding NJ; Jayne DR; Zajicek JP; Meyer PA; Wraight EP; Lockwood CM 《QJM : monthly journal of the Association of Physicians》1997,90(1):61-73
Cerebral vasculitis is a serious but uncommon condition which presents
considerable difficulties in recognition, diagnosis and treatment. We
studied eight consecutive patients in whom this diagnosis was made. Despite
the great diversity of symptoms and signs, we noted three clinical
patterns: (i) acute or sub-acute encephalopathy, (ii) a picture with some
similarities to multiple sclerosis ('MS-plus'), and (iii) features of a
rapidly progressive space-occupying lesion. The identification of these
patterns may help recognition of cerebral vasculitis. The diagnostic value
of four investigative procedures not previously studied in cerebral
vasculitis was assessed: ophthalmological examination using low-dose
fluorescein angiography with slit-lamp video microscopy of the anterior
segment (abnormal in 4/5 patients); spinal fluid oligoclonal band analysis
(abnormal in 3/6 patients); anti-neutrophil cytoplasmic antibody assay
(abnormal in 3/8 patients); and indium-labelled white-cell cerebral imaging
(positive in only one patient). Treatment was with steroid alone (n = 2) or
steroid with cyclophosphamide (n = 6). Seven patients responded clinically.
相似文献
98.
99.
100.
R Kneen MD Nguyen T Solomon NG Pham CM Parry TT Nguyen TL Ha A Taylor TT Vo TT Nguyen NP Day NJ White 《Clinical infectious diseases》2004,39(11):1591-1598
BACKGROUND: Despite the availability of antitoxin and antibiotics, the mortality rate for diphtheria remains high, mostly because of cardiac complications. METHODS: During 1 year, 154 Vietnamese children with diphtheria admitted to a referral hospital were studied prospectively with clinical examination, including a simple pseudomembrane score, 12-lead and 24-hour electrocardiography, measurement of serum cardiac enzyme levels, and estimation of troponin T levels. RESULTS: Thirteen children had diphtheritic cardiomyopathy on admission, and 19 developed it subsequently. Twelve children (8%) died. The combination of pseudomembrane score of >2 and bull neck predicted the development of diphtheritic cardiomyopathy, with a positive predictive value of 83% and a negative predictive value of 93%. Administration of 24-hour electrocardiography on admission improved the ability to predict diphtheritic cardiomyopathy by 57%. Fatal outcome was best predicted by the combination of myocarditis on admission and a pseudomembrane score of >2. Of the cardiac enzyme levels measured, an elevated aspartate aminotransferase level was the best predictor. The presence of troponin T identified additional children with subclinical cardiac damage. CONCLUSIONS: The development of diphtheritic cardiomyopathy can be predicted by means of simple measures. 相似文献